Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Qingwu Jin"'
Autor:
Bill Bingenheimer, Hong Jun-Bae, Qingwu Jin, Michael Welch, Michael Allen Matchett, Erin M. O'brien, James Edward Paul Davidson, Keshab Sarma, Gary R. Lee
Publikováno v:
Organic Process Research & Development. 18:228-238
A scalable and convergent synthesis of a BTK (Bruton’s tyrosine kinase) inhibitor has been developed. Synthetic routes to key intermediates were explored for the scale-up campaign, especially the process for 6-dimethylaminodihydroisoquinolinone, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b1027a98be9ddbbb804a8972b8541c1
https://doi.org/10.1021/op4001077
https://doi.org/10.1021/op4001077
Publikováno v:
Organic Process Research & Development. 14:470-473
An improved synthesis of a 5-HT6 antagonist is described. A problematic amide reduction step was avoided by a reductive amination. Overall, 2.9 kg was produced over 6 steps with an overall yield of 56%.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52f00a52ef28c4db76562447fd60230e
https://doi.org/10.1021/op900319p
https://doi.org/10.1021/op900319p
Autor:
Qingwu Jin, Yu Li, Jennifer Fretland, Julie Q. Hang, Dimitrio Stefanidis, Gabrielle Heilek, Hassan Javanbakht, Jeffrey Wu, Weiling Liang, Fang‐Jie Zhang, Jesper A. Jernelius, Nidhi Arora, Judy M. Suh, Petra Inbar, Michael Welch, Seth F. Harris, Klaus Klumpp, Guoping Su, Donald Roy Hirschfeld, Ralf Roetz, Armando G. Villaseñor, Keshab Sarma, Zachary Kevin Sweeney, J. Roland Billedeau, Joshua Kennedy-Smith, Mark D. Smith, James Edward Paul Davidson
Publikováno v:
ChemMedChem. 4:88-99
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are part of the preferred treatment regimens for individuals infected with HIV. These NNRTI-based regimens are efficacious, but the most popular NNRTIs have a low genetic barrier to resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454bae71e060e01fe27efb0014a6b6df
https://doi.org/10.1002/cmdc.200800262
https://doi.org/10.1002/cmdc.200800262
Autor:
Qingwu Jin, Robert M. Coates
Publikováno v:
Collection of Czechoslovak Chemical Communications. 67:55-74
A series of six methyl enol ether analogs 8-13 of geraniol, (E,E)-farnesol, and (E,E,E)-geranylgeraniol was synthesized from a group of three allylic methyl ethers and three allylic chlorides. Lithiation of the 1-methyl-, or 1-alkenylvinyl ethers wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16d7c209e6e1aa97dddb5423be71a812
https://doi.org/10.1135/cccc20020055
https://doi.org/10.1135/cccc20020055
Publikováno v:
European Journal of Organic Chemistry. 2000:1401-1410
Allylic polyenyl diphosphates such as geranyl and (E,E,E)-geranylgeranyl diphosphates are ubiquitous substrates for monoterpene and diterpene synthases and transferases in isoprenoid biosynthesis. These enzyme substrates were prepared in asymmetrical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d876092ae2ea23c34355235aff10d6b
https://doi.org/10.1002/(sici)1099-0690(200004)2000:8<1401::aid-ejoc1401>3.0.co
https://doi.org/10.1002/(sici)1099-0690(200004)2000:8<1401::aid-ejoc1401>3.0.co
Autor:
Qingwu Jin, Robert M. Coates
Publikováno v:
ChemInform. 33
A series of six methyl enol ether analogs 8 - 13 of geraniol, ( E , E )-farnesol, and ( E , E , E )-geranylgeraniol was synthesized from a group of three allylic methyl ethers and three allylic chlorides. Lithiation of the 1-methyl-, or 1-alkenylviny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7d094303bb0af8643567659d9447cd1
https://doi.org/10.1002/chin.200237191
https://doi.org/10.1002/chin.200237191
Publikováno v:
The Journal of organic chemistry. 70(12)
Taxadiene synthase catalyzes the cyclization of (E,E,E)-geranylgeranyl diphosphate (GGPP) to taxa-4(5),11(12)-diene (Scheme 1, 5 --2) as the first committed step of Taxol biosynthesis. Deuterated GGPPs labeled stereospecifically at C-1, C-4, and C-16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa2c8d5c3433277ca37d98f3470a619
https://pubmed.ncbi.nlm.nih.gov/15932303
https://pubmed.ncbi.nlm.nih.gov/15932303
Autor:
Alan Qingwu Jin, Robert M. Coates
Publikováno v:
The Journal of organic chemistry. 62(21)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b10ae7f8fa9ad1cd021df3135b9328
https://pubmed.ncbi.nlm.nih.gov/11671868
https://pubmed.ncbi.nlm.nih.gov/11671868
Autor:
Dolan Dalal, Alan Qingwu Jin, Robert M. Coates, Mark R. Wildung, Rodney Croteau, John S. Oliver, David C. Williams
Publikováno v:
Archives of biochemistry and biophysics. 379(1)
The diterpene cyclase taxadiene synthase from yew (Taxus) species transforms geranylgeranyl diphosphate to taxa-4(5),11(12)-diene as the first committed step in the biosynthesis of the anti-cancer drug Taxol. Taxadiene synthase is translated as a pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774720b63bd7e3f97b99b4d6bb0575f5
https://pubmed.ncbi.nlm.nih.gov/10864451
https://pubmed.ncbi.nlm.nih.gov/10864451
Autor:
Ralf Roetz, Jesper A. Jernelius, Nidhi Arora, Weiling Liang, Yu Li, Jennifer Fretland, Qingwu Jin, Donald Roy Hirschfeld, Dimitrio Stefanidis, Keshab Sarma, J. Roland Billedeau, Armando G. Villaseñor, Jeffrey Wu, Mark D. Smith, Fang‐Jie Zhang, Julie Q. Hang, Petra Inbar, Hassan Javanbakht, Joshua Kennedy-Smith, James Edward Paul Davidson, Seth F. Harris, Klaus Klumpp, Gabrielle Heilek, Judy M. Suh, Guoping Su, Zachary Kevin Sweeney, Michael Welch
Publikováno v:
ChemMedChem. 4:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39148eed0af75e78690847471466bb83
https://doi.org/10.1002/cmdc.200990000
https://doi.org/10.1002/cmdc.200990000