Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Qingtao Sun"'
Autor:
Qingtao Sun, Daniëlle van de Lisdonk, Miriam Ferrer, Bruno Gegenhuber, Melody Wu, Youngkyu Park, David A. Tuveson, Jessica Tollkuhn, Tobias Janowitz, Bo Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Interleukin-6 (IL-6) has been long considered a key player in cancer cachexia. It is believed that sustained elevation of IL-6 production during cancer progression causes brain dysfunctions, which ultimately result in cachexia. However, how
Externí odkaz:
https://doaj.org/article/0ffe8eb9112f497da2e4fea49fef27ae
Publikováno v:
Molecules, Vol 29, Iss 11, p 2681 (2024)
CDK6 plays a key role in the regulation of the cell cycle and is considered a crucial target for cancer therapy. In this work, conformational transitions of CDK6 were identified by using Gaussian accelerated molecular dynamics (GaMD), deep learning (
Externí odkaz:
https://doaj.org/article/c1071fc903af472f8f0bc45aa888556e
Autor:
Mei Yao, Ayizuohere Tudi, Tao Jiang, Xu An, Qingtao Sun, Anan Li, Z. Josh Huang, Hui Gong, Xiangning Li
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106316- (2023)
Summary: The neocortex mediates information processing through highly organized circuitry that contains various neuron types. Distinct populations of projection neurons in different cortical regions and layers make specific connections and participat
Externí odkaz:
https://doaj.org/article/8b81ce4fdec74956962251ec70514bc0
Autor:
Qingtao Sun, Jianping Zhang, Anan Li, Mei Yao, Guangcai Liu, Siqi Chen, Yue Luo, Zhi Wang, Hui Gong, Xiangning Li, Qingming Luo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Short-term memory deficits are associated with prefrontal cortex dysfunction in Alzheimer’s disease. Here, the authors assessed extratelencephalic projection (ET) neurons and found reduced ET neural activity in the medial prefrontal cortex (mPFC) a
Externí odkaz:
https://doaj.org/article/a6c37a2354db45c4b5212906c6eb1836
Autor:
Zhangheng Ding, Jiangjiang Zhao, Tianpeng Luo, Bolin Lu, Xiaoyu Zhang, Siqi Chen, Anan Li, Xueyan Jia, Jianmin Zhang, Wu Chen, Jianwei Chen, Qingtao Sun, Xiangning Li, Hui Gong, Jing Yuan
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Visualizing the relationships and interactions among different biological components in the whole brain is crucial to our understanding of brain structures and functions. However, an automatic multicolor whole-brain imaging technique is still lacking
Externí odkaz:
https://doaj.org/article/edd6568963dd42548cf28b43673ce0b0
Publikováno v:
Frontiers in Neuroanatomy, Vol 16 (2022)
The pontomesencephalic tegmentum, comprising the pedunculopontine nucleus and laterodorsal tegmental nucleus, is involved in various functions via complex connections; however, the organizational structure of these circuits in the whole brain is not
Externí odkaz:
https://doaj.org/article/6b76f581d9654dab917a471455a341ac
Autor:
Zhengchao Xu, Zhao Feng, Mengting Zhao, Qingtao Sun, Lei Deng, Xueyan Jia, Tao Jiang, Pan Luo, Wu Chen, Ayizuohere Tudi, Jing Yuan, Xiangning Li, Hui Gong, Qingming Luo, Anan Li
Publikováno v:
eLife, Vol 10 (2021)
The dorsal raphe nucleus (DR) and median raphe nucleus (MR) contain populations of glutamatergic and GABAergic neurons that regulate diverse behavioral functions. However, their whole-brain input-output circuits remain incompletely elucidated. We use
Externí odkaz:
https://doaj.org/article/a93515dcd0604a538c51411e832e0ed3
Autor:
Jianping Zhang, Ben Long, Anan Li, Qingtao Sun, Jiaojiao Tian, Ting Luo, Zhangheng Ding, Hui Gong, Xiangning Li
Publikováno v:
Frontiers in Neuroanatomy, Vol 14 (2020)
Axonopathy is a pathological feature observed in both Alzheimer’s disease (AD) patients and animal models. However, identifying the temporal and regional progression of axonopathy during AD development remains elusive. Using the fluorescence micro-
Externí odkaz:
https://doaj.org/article/fc423f5cb44846a39b82ff0cc6a06910
Autor:
Ting Luo, Lei Deng, Anan Li, Can Zhou, Shuai Shao, Qingtao Sun, Hui Gong, Xiaoquan Yang, Xiangning Li
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101717- (2020)
Summary: Resin embedding is widely used to dissect the fine structure of bio-tissue with electron and optical microscopy. However, it is difficult to embed large-volume tissues with resin. Here, we modified the formula of LR-White resin to prevent th
Externí odkaz:
https://doaj.org/article/7612ee497f754595a6860ea102057f37
Publikováno v:
iScience, Vol 23, Iss 3, Pp - (2020)
Summary: Ventral hippocampus (vHIP) and medial prefrontal cortex (mPFC) are both critical regions for social behaviors. However, how their interactions affect social behavior is not well understood. By viral tracing, optogenetics, chemogenetics, and
Externí odkaz:
https://doaj.org/article/7a360b754cbb42f99871262123bac3c5