Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Qingran Kong"'
Autor:
Shuanghui Liu, Fanggui Shao, Yourong Wang, Yurui Zhang, Hongjia Yu, Ningxin Zhang, Lan He, Qingran Kong, Hao Jiang, Zhixiong Dong
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Copy number variations (CNVs) play a vital role in regulating genes expression and tumorigenesis. We explored the copy number alterations in early-stage lung adenocarcinoma using high-throughput sequencing and nucleic acid flight mass spectr
Externí odkaz:
https://doaj.org/article/db50300ee44c49279b58c5722e126dc4
Autor:
Xinyu Wang, Lijun Dai, Yang Liu, Chenghao Li, Dandan Fan, Yue Zhou, Pengcheng Li, Qingran Kong, Jianzhong Su
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-15 (2023)
Abstract Background IDH1/2 hotspot mutations are well known to drive oncogenic mutations in gliomas and are well-defined in the WHO 2021 classification of central nervous system tumors. Specifically, IDH mutations lead to aberrant hypermethylation of
Externí odkaz:
https://doaj.org/article/46b18e44527f447197f04ca7f77948c3
Autor:
Zhixiong Dong, Jinhai Li, Wenqing Dai, Dongbo Yu, Youjuan Zhao, Shuanghui Liu, Xuanwen Li, Zhengzheng Zhang, Rui Zhang, Xue Liang, Qingran Kong, Shengnan Jin, Hao Jiang, Wei Jiang, Chunming Ding
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-15 (2023)
Abstract Ribosome biogenesis (RiBi) plays a pivotal role in carcinogenesis by regulating protein translation and stress response. Here, we find that RRP15, a nucleolar protein critical for RiBi and checkpoint control, is frequently upregulated in pri
Externí odkaz:
https://doaj.org/article/42528bb3297e49eda7cc8158268d8da6
Autor:
Jingyu Li, Jiaming Zhang, Weibo Hou, Xu Yang, Xiaoyu Liu, Yan Zhang, Meiling Gao, Ming Zong, Zhixiong Dong, Zhonghua Liu, Jingling Shen, Weitao Cong, Chunming Ding, Shaorong Gao, Guoning Huang, Qingran Kong
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-20 (2022)
Abstract Metabolism feeds into the regulation of epigenetics via metabolic enzymes and metabolites. However, metabolic features, and their impact on epigenetic remodeling during mammalian pre-implantation development, remain poorly understood. In thi
Externí odkaz:
https://doaj.org/article/11fef895715b4d9787d474fd00f7006b
Autor:
Weibo Hou, Ming Zong, Qi Zhao, Xu Yang, Jiaming Zhang, Shuanghui Liu, Xuanwen Li, Lijun Chen, Chun Tang, Xinyu Wang, Zhixiong Dong, Meiling Gao, Jianzhong Su, Qingran Kong
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107469- (2023)
Summary: Long non-coding RNAs (lncRNAs) have been implicated in diverse biological processes. However, the functional mechanisms have not yet been fully explored. Characterizing the interactions of lncRNAs with chromatin is central to determining the
Externí odkaz:
https://doaj.org/article/58c1e2f280dc4293930e45a4943667a5
Publikováno v:
International Journal of Analytical Chemistry, Vol 2023 (2023)
Objective. Rubi Fructus (RF) is a dry aggregate fruit of Rubus (Rosaceae). It has shown significant pharmacological effects such as anti-oxidation, hypoglycemic, and anti-inflammatory. A combination of near-infrared (NIR) spectroscopy and partial lea
Externí odkaz:
https://doaj.org/article/b991352a79bc4c958cecfe186920c381
Autor:
Xiaolong Liu, Xuran Li, Guangyuan Wu, Pengfei Qi, Yanyan Zhang, Zhiyu Liu, Xinyue Li, Yu Yu, Xiangmei Ye, Yang Li, Dongguang Yang, Yueqiu Teng, Ce Shi, Xin Jin, Sen Qi, Yuting Liu, Shudan Wang, Ying Liu, Fenglin Cao, Qingran Kong, Zhenkun Wang, Hong Zhang
Publikováno v:
Stem Cells International, Vol 2022 (2022)
Objective. Rapid restoration of corneal epithelium integrity after injury is particularly important for preserving corneal transparency and vision. Mesenchymal stem cells (MSCs) can be taken into account as the promising regenerative therapeutics for
Externí odkaz:
https://doaj.org/article/49719a4dd54d476b887458cfef67f5c9
Autor:
Tang Hai, Chunwei Cao, Haitao Shang, Weiwei Guo, Yanshuang Mu, Shulin Yang, Ying Zhang, Qiantao Zheng, Tao Zhang, Xianlong Wang, Yu Liu, Qingran Kong, Kui Li, Dayu Wang, Meng Qi, Qianlong Hong, Rui Zhang, Xiupeng Wang, Qitao Jia, Xiao Wang, Guosong Qin, Yongshun Li, Ailing Luo, Weiwu Jin, Jing Yao, Jiaojiao Huang, Hongyong Zhang, Menghua Li, Xiangmo Xie, Xuejuan Zheng, Kenan Guo, Qinghua Wang, Shibin Zhang, Liang Li, Fei Xie, Yu Zhang, Xiaogang Weng, Zhi Yin, Kui Hu, Yimei Cong, Peng Zheng, Hailong Zou, Leilei Xin, Jihan Xia, Jinxue Ruan, Hegang Li, Weiming Zhao, Jing Yuan, Zizhan Liu, Weiwang Gu, Ming Li, Yong Wang, Hongmei Wang, Shiming Yang, Zhonghua Liu, Hong Wei, Jianguo Zhao, Qi Zhou, Anming Meng
Publikováno v:
eLife, Vol 6 (2017)
N-ethyl-N-nitrosourea (ENU) mutagenesis is a powerful tool to generate mutants on a large scale efficiently, and to discover genes with novel functions at the whole-genome level in Caenorhabditis elegans, flies, zebrafish and mice, but it has never b
Externí odkaz:
https://doaj.org/article/cf41846c1164446c96c69e5c95f2b662
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127512 (2015)
Maternal factors are required for oocyte maturation and embryo development. To better understand the role of DNA methyltransferase 1 (Dnmt1) in oocyte maturation and embryo development, small interfering RNA (siRNA) was conducted in porcine oocytes.
Externí odkaz:
https://doaj.org/article/9eaaccb3aeb147988c1aa213b4836c36
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126607 (2015)
Imprinting disorders induced by somatic cell nuclear transfer (SCNT) usually lead to the abnormalities of cloned animals and low cloning efficiency. Histone deacetylase inhibitors have been shown to improve gene expression, genomic methylation reprog
Externí odkaz:
https://doaj.org/article/529505332387469e96acbb559a59cec3