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Akademický článek

Optimized POCl3-assisted synthesis of 2-amino-1,3,4-thiadiazole/1,3,4-oxadiazole derivatives as anti-influenza agents

Autor: Jianghong Dong, Qinglan Pei, Panpan Wang, Qinge Ma, Wenhui Hu

Publikováno v: Arabian Journal of Chemistry, Vol 15, Iss 4, Pp 103712- (2022)

Although recent decades have witnessed the synthesis of 1,3,4-thiadiazoles via phosphorus POCl3-promoted cyclization reaction, simultaneous access to 2-amino-1,3,4-thiadiazole and 2-amino-1,3,4-oxadiazole analogs remains unexpected and elusive. Herei

Externí odkaz: https://doaj.org/article/e045af514c724073af07262a149a6650

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Exploring the binding mechanism of positive allosteric modulators in human metabotropic glutamate receptor 2 using molecular dynamics simulations

Autor: Fengmei Yan, Chenxi Jing, Ke Zhang, Qinglan Pei, Dong Jianghong, Xiaonan Gao, Xiaobo Xu, Panpan Wang

Publikováno v: Physical Chemistry Chemical Physics. 23:24125-24139

Positive allosteric modulators (PAMs) of human metabotropic glutamate receptor 2 (hmGlu2) are well-known in the treatment of psychiatric disorders for their higher selectivity and lower tolerance risk. A variety of PAMs have been reported over the la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c81e03bc453c103c186350336f205a1
https://doi.org/10.1039/d1cp02157e

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Profiling the structural determinants of aminoketone derivatives as hNET and hDAT reuptake inhibitors by field-based QSAR based on molecular docking

Autor: Qinglan Pei, Xiaobo Xu, Fengmei Yan, Panpan Wang, Pei Yu, Chenxi Jing, Meng Lu

Publikováno v: Technology and Health Care

BACKGROUND: Bupropion, one of the dual norepinephrine and dopamine reuptake inhibitors (NDRIs), is an aminoketone derivative performed effect in improving cognitive function for depression. However, its therapeutic effect is unsatisfactory due to poo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7654ace6a70883a713565a625c6b0bb
https://pubmed.ncbi.nlm.nih.gov/33682763

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Discovery of Novel Mammalian target of rapamycin (mTOR) Inhibitors by Support Vector Machine

Autor: Chenxi Jing, Xiaobo Xu, Panpan Wang, Pei Yu, Meng Lu, Yinghong Li, Qinglan Pei, Bo Li

Publikováno v: IOP Conference Series: Earth and Environmental Science. 692:032028

Mammalian target of rapamycin (mTOR) is a protein serine/threonine kinase playing the central downstream role in multiple mitogenic signalling pathways. As a c entral regulator of cell growth, proliferation, differentiation and survival, mTOR has b e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0a2fa60cacfbaf453f0cdbf6338a1f7
https://doi.org/10.1088/1755-1315/692/3/032028

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