Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Qinghong Han"'
Autor:
Yusuke Aoki, Qinghong Han, Yasunori Tome, Jun Yamamoto, Yutaro Kubota, Noriyuki Masaki, Koya Obara, Kazuyuki Hamada, Justin D. Wang, Sachiko Inubushi, Michael Bouvet, Steven G. Clarke, Kotaro Nishida, Robert M. Hoffman
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Methionine addiction, a fundamental and general hallmark of cancer, known as the Hoffman Effect, is due to altered use of methionine for increased and aberrant transmethylation reactions. However, the linkage of methionine addiction and malignancy of
Externí odkaz:
https://doaj.org/article/97c077fb9c4b486fa0ac8b7bb108f0b6
Autor:
Jun Yamamoto, Sachiko Inubushi, Qinghong Han, Yoshihiko Tashiro, Norihiko Sugisawa, Kazuyuki Hamada, Yusuke Aoki, Kentaro Miyake, Ryusei Matsuyama, Michael Bouvet, Steven G. Clarke, Itaru Endo, Robert M. Hoffman
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104162- (2022)
Summary: Methionine addiction, found in all types of cancer investigated, is because of the overuse of methionine by cancer cells for excess transmethylation reactions. In the present study, we compared the histone H3 lysine-methylation status and de
Externí odkaz:
https://doaj.org/article/406428cf8097463ba54fc0fc565fe04d
Autor:
Yutaro Kubota, Toshihiko Sato, Chihiro Hozumi, Qinghong Han, Yusuke Aoki, Noriyuki Masaki, Koya Obara, Takuya Tsunoda, Robert M. Hoffman
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 1935 (2023)
Positron emission tomography (PET) is widely used to detect cancers. The usual isotope for PET imaging of cancer is [18F]deoxyglucose. The premise of using [18F]deoxyglucose is that cancers are addicted to glucose (The Warburg effect). However, cance
Externí odkaz:
https://doaj.org/article/c0c92638714e44c296e7d1f9142f908a
Autor:
Yusuke Aoki, Yasunori Tome, Qinghong Han, Jun Yamamoto, Kazuyuki Hamada, Noriyuki Masaki, Michael Bouvet, Kotaro Nishida, Robert M. Hoffman
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss , Pp 101177- (2021)
Methionine addiction is a fundamental and general hallmark of cancer cells, which require exogenous methionine, despite their ability to synthesize normal amounts of methionine from homocysteine. In contrast, methionine-independent normal cells do no
Externí odkaz:
https://doaj.org/article/c24b297ccc054f82a299b92b8ee866f1
Autor:
Guangwei Zhu, Ming Zhao, Qinghong Han, Yuying Tan, Yu Sun, Michael Bouvet, Bryan Clary, Shree Ram Singh, Jianxin Ye, Robert M. Hoffman
Publikováno v:
Translational Oncology, Vol 13, Iss 3, Pp - (2020)
Purpose: The goal of the present study was to determine the efficacy of temozolomide (TEM) and pazopanib (PAZ) combined with FOLFOX (oxaliplatin, leucovorin and 5-fluorouracil) on a colorectal cancer patient-derived orthotopic xenograft (PDOX) mouse
Externí odkaz:
https://doaj.org/article/31fc435467ca4c34ba1461a117d16831
Autor:
Kei Kawaguchi, Qinghong Han, Shukuan Li, Yuying Tan, Kentaro Igarashi, Takashi Murakami, Michiaki Unno, Robert M. Hoffman
Publikováno v:
Cells, Vol 8, Iss 5, p 410 (2019)
An excessive requirement for methionine (MET), termed MET dependence, appears to be a general metabolic defect in cancer and has been shown to be a very effective therapeutic target. MET restriction (MR) has inhibited the growth of all major cancer t
Externí odkaz:
https://doaj.org/article/3787b8b17e1445f2bbf7773c56eeff06
Autor:
KOHEI MIZUTA, RYOSUKE MORI, QINGHONG HAN, SEI MORINAGA, MOTOKAZU SATO, BYUNG MO KANG, BOUVET, MICHAEL, YASUNORI TOME, KOTARO NISHIDA, HOFFMAN, ROBERT M.
Publikováno v:
Cancer Diagnosis & Prognosis; Jul/Aug2024, Vol. 4 Issue 4, p402-407, 6p
Autor:
ARDJMAND, DANIEL, MOTOKAZU SATO, QINGHONG HAN, YUTARO KUBOTA, KOHEI MIZUTA, SEI MORINAGA, HOFFMAN, ROBERT M.
Publikováno v:
Cancer Diagnosis & Prognosis; Jul/Aug2024, Vol. 4 Issue 4, p396-401, 6p
Autor:
KOHEI MIZUTA, BYUNG MO KANG, QINGHONG HAN, YUTARO KUBOTA, SEI MORINAGA, MOTOKAZU SATO, BOUVET, MICHAEL, YASUNORI TOME, KOTARO NISHIDA, HOFFMAN, ROBERT M.
Publikováno v:
Cancer Genomics & Proteomics (1109-6535); Jul/Aug2024, Vol. 21 Issue 4, p395-398, 4p
Autor:
MOTOKAZU SATO, QINGHONG HAN, KOHEI MIZUTA, RYOSUKE MORI, BYUNG MO KANG, SEI MORINAGA, NORITOSHI KOBAYASHI, YASUSHI ICHIKAWA, ATSUSHI NAKAJIMA, HOFFMAN, ROBERT M.
Publikováno v:
In Vivo; May/Jun2024, Vol. 38 Issue 3, p1459-1464, 6p