Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Qingguang Jiang"'
Publikováno v:
Neurotherapeutics. 5:481-489
Alzheimer's disease (AD) is characterized by the deposition of beta-amyloid within the brain parenchyma and is accompanied by the impairment of neuronal metabolism and function, leading to extensive neuronal loss. The disease involves the perturbatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc72f1fbbdd3b76388eb6c382871311a
https://doi.org/10.1016/j.nurt.2008.05.003
https://doi.org/10.1016/j.nurt.2008.05.003
Autor:
Noam Zelcer, Timothy M. Willson, C. Y. Daniel Lee, Jill C. Richardson, Shweta Mandrekar, David M. Holtzman, Jon L. Collins, Jonathan D. Smith, Qingguang Jiang, Gary E. Landreth, David Riddell, Paige E. Cramer, Karen Mann, Peter Tontonoz, Brandy L. Wilkinson, Bruce T. Lamb, Thomas A. Comery
Publikováno v:
Neuron, 58(5), 681-693. Cell Press
Apolipoprotein E is associated with age-related risk for Alzheimer’s disease and plays critical roles in Aβ homeostasis. We report that ApoE plays a previously unappreciated role in facilitating the proteolytic clearance of soluble Aβ from the br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f090b04173c3ef71059dfec8aea90212
Autor:
Christian Grommes, Gary E. Landreth, Brandy L. Wilkinson, C. Y. Daniel Lee, Jessica Koenigsknecht-Talboo, Brian Varnum, Qingguang Jiang
Publikováno v:
Journal of Neuroimmune Pharmacology. 3:130-140
Removal of apoptotic cells is an essential process for normal development and tissue maintenance. Importantly, apoptotic cells stimulate their phagocytosis by macrophages while actively suppressing inflammatory responses. Growth arrest specific gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136a7fabd9466df84410d8180f18c53f
https://doi.org/10.1007/s11481-007-9090-2
https://doi.org/10.1007/s11481-007-9090-2
Autor:
Katherine A. Hajjar, Annie A. Wu, Elizabeth M. Jaffee, Guanglan Mo, Ashley Leubner, Christine A. Iacobuzio-Donahue, Jennifer Kleponis, Anirban Maitra, Donger Zhou, Robert A. Anders, Agnieszka A. Rucki, Rajni Sharma, Qingguang Jiang, Kelly Foley, Qian Xiao, Lei Zheng
Publikováno v:
Science Signaling. 8
Most patients with pancreatic ductal adenocarcinoma (PDA) present with metastatic disease at the time of diagnosis or will recur with metastases after surgical treatment. Semaphorin-plexin signaling mediates the migration of neuronal axons during dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a9b46dfffb9a8aad39b108a2180469
https://doi.org/10.1126/scisignal.aaa5823
https://doi.org/10.1126/scisignal.aaa5823
Autor:
Raquel M. Fernández, Seneca L. Bessling, Grzegorz M. Burzynski, Albee Y. Ling, Salud Borrego, Isabella Ceccherini, Andrew S. McCallion, Aravinda Chakravarti, Moltu Guy, Robert M.W. Hofstra, Qian Jiang, Stacey Arnold, Jeffrey J. Gray, Jeanne Amiel, Krishna Praneeth Kilambi, Maria X. Sosa, Vassilis Pachnis, Betty Q. Doan, Ashish Kapoor, Stanislas Lyonnet, Qingguang Jiang, Tiffany A. Heanue, Kristen West, Joke B. G. M. Verheij, Paola Griseri
Publikováno v:
American Journal of Human Genetics, 96(4), 581-596. Cell Press
American Journal of Human Genetics, 96(4), 581-596. CELL PRESS
American Journal of Human Genetics, 96(4), 581-596. CELL PRESS
Innervation of the gut is segmentally lost in Hirschsprung disease (HSCR), a consequence of cell-autonomous and non-autonomous defects in enteric neuronal cell differentiation, proliferation, migration, or survival. Rare, high-penetrance coding varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd2d4cf6a8b58b92cd0ab303717bf29
https://pure.eur.nl/en/publications/c46aadce-e454-4bda-9baf-da43fde81518
https://pure.eur.nl/en/publications/c46aadce-e454-4bda-9baf-da43fde81518
Publikováno v:
Neurochemistry International. 49:136-144
Diseases of the central nervous system present a challenge for the development of new therapeutic agents. Nuclear receptors are ligand-activated transcription factors that have proven to be valuable targets for development of new drugs owing to their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa2e85f4ea457637459135770cbf667
https://doi.org/10.1016/j.neuint.2006.03.020
https://doi.org/10.1016/j.neuint.2006.03.020
Autor:
David M. Holtzman, Qingguang Jiang, Jessica Koenigsknecht-Talboo, Shweta Mandrekar, Gary E. Landreth, C. Y. Daniel Lee
Alzheimer's disease is characterized by the progressive deposition of β-amyloid (Aβ) within the brain parenchyma and its subsequent accumulation into senile plaques. Pathogenesis of the disease is associated with perturbations in Aβ homeostasis an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94216e611ce06dc01d3a7380acf8e0c
https://europepmc.org/articles/PMC3034143/
https://europepmc.org/articles/PMC3034143/
Publikováno v:
Topics in Medicinal Chemistry ISBN: 9783540742289
Alzheimer's disease (AD) is a complex neurodegenerative disorder with aging, genetic and environmental factors contributing to the development and progression of the disease. The complexity of this disease presents substantial challenges for the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30ba3bbc557e11808ba75eee7fd3ca70
https://doi.org/10.1007/7355_2007_014
https://doi.org/10.1007/7355_2007_014
Autor:
Qingguang Jiang, Noam Zelcer, Negar Khanlou, Gary E. Landreth, Erin G. Reed-Geaghan, Ryan Clare, Harry V. Vinters, Peter Tontonoz
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 104(25), 10601-10606. National Academy of Sciences
Alzheimer's disease (AD) is an age-dependent neurodegenerative disease that causes progressive cognitive impairment. The initiation and progression of AD has been linked to cholesterol metabolism and inflammation, processes that can be modulated by l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5ce30f79a207f72865a047d1a3346b
https://pubmed.ncbi.nlm.nih.gov/17563384
https://pubmed.ncbi.nlm.nih.gov/17563384
Autor:
Karl Herrup, Paige E. Cramer, Erin G. Reed-Geaghan, Nicholas H. Varvel, Brandy L. Wilkinson, Qingguang Jiang, Bruce T. Lamb, Alison Szabo, Gary E. Landreth
Publikováno v:
Neurobiology of Aging. 33:197.e21-197.e32
Considerable evidence points to important roles for inflammation in Alzheimer's disease (AD) pathophysiology. Epidemiological studies have suggested that long-term nonsteroidal anti-inflammatory drug (NSAID) therapy reduces the risk for Alzheimer's d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8831182317c2b65ce49ed4fa583e621b
https://doi.org/10.1016/j.neurobiolaging.2010.06.014
https://doi.org/10.1016/j.neurobiolaging.2010.06.014