Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Qingduan Wang"'
Autor:
Jingmin Zhang, Yafeng Wang, Youmei Peng, Chongzhen Qin, Yixian Liu, Jingjing Li, Jinhua Jiang, Yubing Zhou, Junbiao Chang, Qingduan Wang
Publikováno v:
Brazilian Journal of Infectious Diseases, Vol 22, Iss 6, Pp 477-486 (2018)
Antiviral drug resistance is the most important factor contributing to treatment failure using nucleos(t)ide analogs such as lamivudine for chronic infection with hepatitis B virus (HBV). Development of a system supporting efficient replication of cl
Externí odkaz:
https://doaj.org/article/dc52b324b3cf486da589969b4560be2f
Autor:
Yan Zhang, Rong Zhang, Xixi Ding, Bangan Peng, Ning Wang, Fang Ma, Youmei Peng, Qingduan Wang, Junbiao Chang
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174112 (2017)
FNC, 2'-deoxy-2'-β-fluoro-4'-azidocytidine, is a novel cytidine analogue, that has shown strong antiproliferative activity in human lymphoma, lung adenocarcinoma and acute myeloid leukemia. In this study, we investigated the effects of FNC on mantle
Externí odkaz:
https://doaj.org/article/8a63b82055d746c9a72add6da0928782
Autor:
Qinghua Yang, Xuejie Zhao, Wenquan Yu, Wu He, Xianzhen Fang, Limin Zang, Na Wan, Qingduan Wang, Liyun Zheng, Junbiao Chang
Publikováno v:
Journal of Pharmacological Sciences, Vol 126, Iss 3, Pp 208-215 (2014)
Abstract.: A novel codrug, α-DDB-FNCG, was synthesized through coupling of α-biphenyl dimethyl dicarboxylate (α-DDB) and the nucleoside analogue FNCG, via an ester bond. The anti-HBV activity and hepatoprotective effects of this compound were inve
Externí odkaz:
https://doaj.org/article/b0ea4a292e7d450e93bce32353f3fedd
Autor:
Jingmin Zhang, Yafeng Wang, Youmei Peng, Chongzhen Qin, Yixian Liu, Jingjing Li, Jinhua Jiang, Yubing Zhou, Junbiao Chang, Qingduan Wang
Publikováno v:
Brazilian Journal of Infectious Diseases, Vol 22, Iss 6, Pp 477-486
ABSTRACT Antiviral drug resistance is the most important factor contributing to treatment failure using nucleos(t)ide analogs such as lamivudine for chronic infection with hepatitis B virus (HBV). Development of a system supporting efficient replicat
Externí odkaz:
https://doaj.org/article/d3a332b3f2f74a43b758af14837b2112
Autor:
Shuai Niu, Yi Liang, Wanying Yue, Yi Zhang, Junbiao Chang, Qingduan Wang, Huiping Chen, Ning Wang, Youmei Peng, Yan Zhang, Fang Ma, Xiang Jing
Publikováno v:
Genes & Genomics. 44:123-131
Previously, we published that 4′-azid-2′-deoxy-2′-fluorarabinoside (FNC), a novel cytosine nucleoside analog, has good anti-viral and anti-tumor activity. This study aimed to further explore the role and molecular mechanism of FNC in non-small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e1d329601deffce0598c283bf2963d
https://doi.org/10.1007/s13258-021-01179-9
https://doi.org/10.1007/s13258-021-01179-9
Autor:
Xiaokai Zhuan, Chang Junbiao, Youmei Peng, Yafeng Wang, Zongxian Liang, He Huang, Chenzheng Huang, Qingduan Wang, Qing Li
Publikováno v:
Acta virologica. 65(1)
Coxsackie virus B3 (CVB3) is believed to be a major cause of viral myocarditis, with virus-induced apoptosis playing an important role in pathogenesis. The purpose of this study was to characterize the antiviral activity of a novel fluoronucleoside a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6a92d9af95ec940c9e660a4fd4c41a
https://pubmed.ncbi.nlm.nih.gov/33827222
https://pubmed.ncbi.nlm.nih.gov/33827222
Autor:
Yi Liang, Qingduan Wang, Yi Zhang, Shuai Niu, Wanying Yue, Junbiao Chang, Ning Wang, Yan Zhang, Xiang Jing, Youmei Peng, Fang Ma, Huiping Chen
Background: Non-small-cell lung cancer (NSCLC) is associated with the highest morbidity and mortality rate, and chemotherapy is the primary therapy for NSCLC. However, the clinical outcome is still far from satisfactory. This study aimed to determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0293f40d363d0bb111acab4e1a39fcf3
https://doi.org/10.21203/rs.3.rs-219276/v1
https://doi.org/10.21203/rs.3.rs-219276/v1
Publikováno v:
Evidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
Prunella vulgaris, a traditional Chinese medicine, has been used to treat various benign and malignant tumours for centuries in China. In our previous studies, Prunella vulgaris extract (PVE) was shown to promote apoptosis in differentiated thyroid c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3c9d4c2eae18baef8e89ebeb9f3c48
Autor:
Junbiao Chang, Jian-Hua Wang, Qingduan Wang, Youmei Peng, Zhifu Han, Li Sun, Lan Liang, Meng-Li Wu, Bailing Zhang, Jiao Hou, Yan Qiao, Dongwei Zhang, Wenquan Yu, Jijie Chai, Xia Jin, Ertong Li, Jingyu Chen, Yan Zhang, Zhiwei Huang, Chuanjun Song, Qing-Xia Zhao
Publikováno v:
Journal of medicinal chemistry. 63(15)
In preclinical and phase I and II clinical studies, 2'-deoxy-2'-β-fluoro-4'-azidocytidine (FNC) displays a potent and long-lasting inhibition of HIV-1 infection. To investigate its mechanism of action, we compared it with the well-documented lamivud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3335df92e19be061c4f21248f0ace54b
https://pubmed.ncbi.nlm.nih.gov/32678592
https://pubmed.ncbi.nlm.nih.gov/32678592
Autor:
Yan Zhang, Chenzheng Huang, Junbiao Chang, Jinhua Jiang, Qingduan Wang, Bingjie Liu, Ning Wang, Youmei Peng, Yixian Liu
Publikováno v:
European Journal of Pharmaceutical Sciences. 105:150-158
2′-Deoxy-2′-β-fluoro-4′-azidocytidine (FNC), a cytidine analog, has attracted great interest because of its potent activity against wild-type and multidrug-resistant HIV. The purpose of current study was to investigate the absorption mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f483d9becc4a08d36498dc4e25d698
https://doi.org/10.1016/j.ejps.2017.05.009
https://doi.org/10.1016/j.ejps.2017.05.009