Zobrazeno 1 - 10
of 299
pro vyhledávání: '"Qingchun Tong"'
Autor:
Zhiying Jiang, Michelle He, Claire Young, Jing Cai, Yuanzhong Xu, Yanyan Jiang, Hongli Li, Maojie Yang, Qingchun Tong
Publikováno v:
Advanced Science, Vol 11, Iss 36, Pp n/a-n/a (2024)
Abstract Dopaminergic (DA) neurons are known to play a key role in controlling behaviors. While DA neurons in other brain regions are extensively characterized, those in zona incerta (ZITH or A13) receive much less attention and their function remain
Externí odkaz:
https://doaj.org/article/50e6f98fb98544b49c524ead9ca85816
Autor:
Rachel Van Drunen, Yulin Dai, Haichao Wei, Baharan Fekry, Sina Noori, Samay Shivshankar, Rafael Bravo, Zhongming Zhao, Seung-hee Yoo, Nicholas Justice, Jia Qian Wu, Qingchun Tong, Kristin Eckel-Mahan
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114380- (2024)
Summary: Circadian rhythms are internal biological rhythms driving temporal tissue-specific, metabolic programs. Loss of the circadian transcription factor BMAL1 in the paraventricular nucleus (PVN) of the hypothalamus reveals its importance in metab
Externí odkaz:
https://doaj.org/article/f22c96455dcb4bc4974719b6c4a5baca
Autor:
Hongli Li, Yuanzhong Xu, Yanyan Jiang, Zhiying Jiang, Joshua Otiz-Guzman, Jessie C. Morrill, Jing Cai, Zhengmei Mao, Yong Xu, Benjamin R. Arenkiel, Cheng Huang, Qingchun Tong
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The melanocortin action is well perceived for its ability to regulate body weight bidirectionally with its gain of function reducing body weight and loss of function promoting obesity. However, this notion cannot explain the difficulty in id
Externí odkaz:
https://doaj.org/article/177a82bcc91a473689a0ebd04e5a3682
Autor:
Jessica L. Swanson, Joshua Ortiz-Guzman, Snigdha Srivastava, Pey-Shyuan Chin, Sean W. Dooling, Elizabeth Hanson Moss, Mikhail Y. Kochukov, Patrick J. Hunt, Jay M. Patel, Brandon T. Pekarek, Qingchun Tong, Benjamin R. Arenkiel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-20 (2022)
Abstract Environmental cues and internal states such as mood, reward, or aversion directly influence feeding behaviors beyond homeostatic necessity. The hypothalamus has been extensively investigated for its role in homeostatic feeding. However, many
Externí odkaz:
https://doaj.org/article/5d232b3b14fd4f96ad62d5637a6f7ab4
Autor:
Longlong Tu, Jonathan C. Bean, Yang He, Hailan Liu, Meng Yu, Hesong Liu, Nan Zhang, Na Yin, Junying Han, Nikolas A. Scarcelli, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Bing Feng, Peiyu Gao, Zhao-Lin Cai, Makoto Fukuda, Mingshan Xue, Qingchun Tong, Yongjie Yang, Lan Liao, Jianming Xu, Chunmei Wang, Yanlin He, Yong Xu
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 14 (2023)
Glucose is the basic fuel essential for maintenance of viability and functionality of all cells. However, some neurons — namely, glucose-inhibited (GI) neurons — paradoxically increase their firing activity in low-glucose conditions and decrease
Externí odkaz:
https://doaj.org/article/db791eea21694462991bc49ae75e64ed
Autor:
Jing Cai, Jing Chen, Joshua Ortiz-Guzman, Jessica Huang, Benjamin R. Arenkiel, Yuchen Wang, Yan Zhang, Yuyan Shi, Qingchun Tong, Cheng Zhan
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112789- (2023)
Summary: In addition to their role in promoting feeding and obesity development, hypothalamic arcuate agouti-related protein/neuropeptide Y (AgRP/NPY) neurons are widely perceived to be indispensable for maintaining normal feeding and body weight in
Externí odkaz:
https://doaj.org/article/281dffa5e34e4f20bd07b0311edb3afa
Autor:
Yuanzhong Xu, Zhiying Jiang, Hongli Li, Jing Cai, Yanyan Jiang, Joshua Ortiz-Guzman, Yong Xu, Benjamin R. Arenkiel, Qingchun Tong
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112626- (2023)
Externí odkaz:
https://doaj.org/article/e1b7f5590ded4cfc9f229dd90a091490
Autor:
Peng Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan, Zhiqiang Ku, Leike Li, Xiaoye Liu, Mi Deng, Hisashi Arase, Jay-Jiguang Zhu, Timothy Y. Huang, Yingjun Zhao, Chengcheng Zhang, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang An
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-28 (2022)
Abstract Background Microglia plays crucial roles in Alzheimer’s disease (AD) development. Triggering receptor expressed on myeloid cells 2 (TREM2) in association with DAP12 mediates signaling affecting microglia function. Here we study the negativ
Externí odkaz:
https://doaj.org/article/375488437204489ba10baa9354be3594
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract The brain, particularly the ventromedial hypothalamic nucleus (VMH), has been long known for its involvement in glucose sensing and whole-body glucose homeostasis. However, it is still not fully understood how the brain detects and responds
Externí odkaz:
https://doaj.org/article/3be4636ba67d420aa21b1e828676d41d
Autor:
Peng Zhao, Yuanzhong Xu, Xuejun Fan, Leike Li, Xin Li, Hisashi Arase, Qingchun Tong, Ningyan Zhang, Zhiqiang An
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Triggering receptor expressed on myeloid cells 2 (TREM2) plays a crucial role in regulating microglial functions and removal of amyloid plaques in Alzheimer’s disease (AD). However, therapeutics based on this knowledge have not been developed due t
Externí odkaz:
https://doaj.org/article/5093d920b0ad4f4d8f7908288e6c3aac