Zobrazeno 1 - 10 of 112 pro vyhledávání: '"Qingcheng Mao"'
1
Akademický článek
SLC20a1/PiT-1 is required for chorioallantoic placental morphogenesis
Autor: Ana Correia-Branco, Ariel Mei, Sreehari Pillai, Nirmala Jayaraman, Radhika Sharma, Alison G Paquette, Naveen K Neradugomma, Ciara Benson, Nicholas W Chavkin, Qingcheng Mao, Mary C Wallingford
Publikováno v: Vascular Biology, Vol 5, Iss 1, Pp 1-14 (2023)
The placenta mediates the transport of nutrients, such as inorganic phosphate (Pi), between the maternal and fetal circulatory systems. The placenta itself also requires high levels of nutrient uptake as it develops to provide critical support for fe
Externí odkaz: https://doaj.org/article/97fa70e62eb8493dabfab01c45b0f293
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2
Akademický článek
Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells
Autor: Yik Pui Tsang, Tianran Hao, Qingcheng Mao, Edward J. Kelly, Jashvant D. Unadkat
Publikováno v: Pharmaceutics, Vol 16, Iss 2, p 285 (2024)
Proinflammatory cytokines, which are elevated during inflammation or infections, can affect drug pharmacokinetics (PK) due to the altered expression or activity of drug transporters and/or metabolizing enzymes. To date, such studies have focused on t
Externí odkaz: https://doaj.org/article/a878d313ce8d4604ac3a28b41e146eda
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3
Akademický článek
Key hepatic metabolic pathways are altered in germ-free mice during pregnancy.
Autor: Lyrialle W Han, Yuanyuan Shi, Alison Paquette, Lu Wang, Theo K Bammler, Qingcheng Mao
Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0248351 (2021)
Pregnancy is associated with metabolic changes to accommodate the mother and her growing fetus. The microbiome has been shown to modulate host metabolism of endogenous and exogenous substances. However, the combined effects of pregnancy and the micro
Externí odkaz: https://doaj.org/article/972561b68d93409ca79157e1e2392834
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5
An update on placental drug transport and its relevance to fetal drug exposure
Autor: Xin Chen, Qingcheng Mao
Publikováno v: Medical Review. 2:501-511
Pregnant women are often complicated with diseases that require treatment with medication. Most drugs administered to pregnant women are off-label without the necessary dose, efficacy, and safety information. Knowledge concerning drug transfer across
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9590ada2e4d7d69d8f5671249664ed6d
https://doi.org/10.1515/mr-2022-0025
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9
Tetrahydrocannabinol and Its Major Metabolites Are Not (or Are Poor) Substrates or Inhibitors of Human P-Glycoprotein [ATP-Binding Cassette (ABC) B1] and Breast Cancer Resistance Protein (ABCG2)
Autor: Jashvant D. Unadkat, Qingcheng Mao, Xin Chen
Publikováno v: Drug Metab Dispos
(−)-Δ(9)-Tetrahydrocannabinol (THC) is the primary psychoactive constituent of cannabis. In humans, 11-hydroxy-THC (11-OH-THC) and 11-nor-9-carboxy-THC (THC-COOH) are psychoactive and nonpsychoactive circulating metabolites of THC, respectively. W
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f47edf8537fc55ae3a3a5da9721d03
https://doi.org/10.1124/dmd.121.000505
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