Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Qingbin Kong"'
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-17 (2020)
Abstract Insulin-like growth factors (IGFs) play important roles in mammalian growth, development, aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and tumor progression, thus providing the rationale for targeting IGF
Externí odkaz:
https://doaj.org/article/06b4649cf99c46b3b9e47959cf51443a
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-19 (2019)
Abstract Mechanistic target of rapamycin (mTOR) is a protein kinase regulating cell growth, survival, metabolism, and immunity. mTOR is usually assembled into several complexes such as mTOR complex 1/2 (mTORC1/2). In cooperation with raptor, rictor,
Externí odkaz:
https://doaj.org/article/b2f26c6c535c4e95a373b46bd7052153
Publikováno v:
Experimental Hematology & Oncology, Vol 7, Iss 1, Pp 1-11 (2018)
Abstract Estrogen is a steroid hormone that has critical roles in reproductive development, bone homeostasis, cardiovascular remodeling and brain functions. However, estrogen also promotes mammary, ovarian and endometrial tumorigenesis. Estrogen anta
Externí odkaz:
https://doaj.org/article/8c7e28e0a0b84f949d141cdf5ed90e68
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47961 (2012)
Aflatoxin B1 (AFB1) is a potent carcinogen that can induce hepatocellular carcinoma. AFB1-8,9-exo-epoxide, one of AFB1 metabolites, acts as a mutagen to react with DNA and induce gene mutations, including the tumor suppressor p53. In addition, AFB1 r
Externí odkaz:
https://doaj.org/article/6e720198f7c449bdba87b67bc0158bc9
Publikováno v:
British Journal of Pharmacology. 178:4389-4407
Background and purpose The multikinase inhibitor sorafenib is a first-line drug for advanced hepatocellular carcinoma. The response to sorafenib varies among hepatocellular carcinoma patients and many of the responders suffer from reduced sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d8a0ad0448fb33f4b354feaf0d9acc0
https://doi.org/10.1111/bph.15616
https://doi.org/10.1111/bph.15616
Autor:
Songpeng, Yang, Shu, Yang, Hongying, Zhang, Hui, Hua, Qingbin, Kong, Jiao, Wang, Yangfu, Jiang
Publikováno v:
British journal of pharmacologyREFERENCES. 178(21)
The multikinase inhibitor sorafenib is a first-line drug for advanced hepatocellular carcinoma. The response to sorafenib varies among hepatocellular carcinoma patients and many of the responders suffer from reduced sensitivity after long-term treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c7bdba1b325c1f71e19fa3350636c451
https://pubmed.ncbi.nlm.nih.gov/34233013
https://pubmed.ncbi.nlm.nih.gov/34233013
Publikováno v:
Experimental Hematology & Oncology
Cyclic adenosine monophosphate (cAMP) is the first discovered second messenger, which plays pivotal roles in cell signaling, and regulates many physiological and pathological processes. cAMP can regulate the transcription of various target genes, mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8787f34dad281bb5a18ee84c41470ad1
http://europepmc.org/articles/PMC7684908
http://europepmc.org/articles/PMC7684908
Publikováno v:
Medicinal Research Reviews. 39:114-145
The nonsteroidal anti-inflammatory agent aspirin is widely used for preventing and treating cardiovascular and cerebrovascular diseases. In addition, epidemiologic evidences reveal that aspirin may prevent a variety of human cancers, while data on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e34265c1490ab04b2f6e84fc93cc933
https://doi.org/10.1002/med.21514
https://doi.org/10.1002/med.21514
Publikováno v:
Oncotarget
AMP-activated protein kinase (AMPK) is an important energy sensor that may inhibit cell proliferation or promote cell survival during stresses. Besides cyclooxygenase, AMPK is another target of the nonsteroid anti-inflammatory agent aspirin. Preclini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624721cd38055ec09be2b13e5e8e261a
http://europepmc.org/articles/PMC4941319
http://europepmc.org/articles/PMC4941319
Autor:
Yangfu Jiang, Songpeng Yang, Qingbin Kong, Peiying Song, Hongying Zhang, Jiao Wang, Hui Hua, Ting Luo
Publikováno v:
The Journal of biological chemistry. 294(15)
GADD34 (growth arrest and DNA damage-inducible gene 34) plays a critical role in responses to DNA damage and endoplasmic reticulum stress. GADD34 has opposing effects on different stimuli-induced cell apoptosis events, but the reason for this is uncl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73db11954b2310f7591ff0547d21ba8
https://pubmed.ncbi.nlm.nih.gov/30782845
https://pubmed.ncbi.nlm.nih.gov/30782845