Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Qingbin Cui"'
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Mitochondria are promising drug target for cancer treatment. We previously demonstrated that a bi-gold compound BGC2a was more potent than the mono-gold drug auranofin in suppressing cancer cells due to increased gold atom number that led to higher d
Externí odkaz:
https://doaj.org/article/c19827921137433ea5c15bb0b312c67d
The AKT inhibitor, MK-2206, attenuates ABCG2-mediated drug resistance in lung and colon cancer cells
Autor:
Hai-Ling Gao, Qingbin Cui, Jing-Quan Wang, Charles R. Ashby, Yanchun Chen, Zhi-Xin Shen, Zhe-Sheng Chen
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: The overexpression of ATP-binding cassette (ABC) transporters, ABCB1 and ABCG2, are two of the major mediators of multidrug resistance (MDR) in cancers. Although multiple ABCB1 and ABCG2 inhibitors have been developed and some have unde
Externí odkaz:
https://doaj.org/article/b3931dbcbd2048c398cc1269d077d2a0
Autor:
Jing‐Quan Wang, Qingbin Cui, Zi‐Ning Lei, Qiu‐Xu Teng, Ning Ji, Lusheng Lin, Zhijun Liu, Zhe‐Sheng Chen
Publikováno v:
MedComm, Vol 2, Iss 2, Pp 221-235 (2021)
Abstract ATP‐binding cassette (ABC) transporters superfamily mediates multidrug resistance in cancer by extruding structurally distinct chemotherapeutic agents, causing failure in chemotherapy. Among the 49 ABC transporters, multidrug resistance pr
Externí odkaz:
https://doaj.org/article/aa7478f51fa24bd1aa772447a85498d1
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/7f8278fec4c042a1ba22d485dd9e37e2
Autor:
Xing-Duo Dong, Meng Zhang, Chao-Yun Cai, Qiu-Xu Teng, Jing-Quan Wang, Yi-Ge Fu, Qingbin Cui, Ketankumar Patel, Dong-Tao Wang, Zhe-Sheng Chen
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The KRAS-G12C inhibitor ARS-1620, is a novel specific covalent inhibitor of KRAS-G12C, possessing a strong targeting inhibitory effect on KRAS-G12C mutant tumors. Overexpression of ATP-binding cassette super-family B member 1 (ABCB1/P-gp) is one of t
Externí odkaz:
https://doaj.org/article/a06b350b27f64a4eb5eb02d4b307d432
Autor:
Yuqi Yang, Ning Ji, Chao‐Yun Cai, Jing‐Quan Wang, Zi‐Ning Lei, Qiu‐Xu Teng, Zhuo‐Xun Wu, Qingbin Cui, Yihang Pan, Zhe‐Sheng Chen
Publikováno v:
Cancer Communications, Vol 40, Iss 7, Pp 285-300 (2020)
Abstract Background Overexpression of ATP‐binding cassette (ABC) transporter is a major contributor to multidrug resistance (MDR), in which cancer cells acquire resistance to a wide spectrum of chemotherapeutic drugs. In this work, we evaluated the
Externí odkaz:
https://doaj.org/article/2058e8ae16504875a4110aa539486d5e
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Heart failure (HF), the leading cause of death among men and women world-wide, causes great health and economic burdens. HF can be triggered by many factors, such as coronary artery disease, heart attack, cardiomyopathy, hypertension, obesity, etc.,
Externí odkaz:
https://doaj.org/article/b9b1b2d423a0402c854c8caea2181927
Autor:
Qingbin Cui, Wenwen Ding, Panpan Liu, Bingling Luo, Jing Yang, Wenhua Lu, Yumin Hu, Peng Huang, Shijun Wen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12169 (2022)
Reactive oxygen species (ROS) homeostasis and mitochondrial metabolism are critical for the survival of cancer cells, including cancer stem cells (CSCs), which often cause drug resistance and cancer relapse. Auranofin is a mono-gold anti-rheumatic dr
Externí odkaz:
https://doaj.org/article/cb6173588e434c40af4344c338ab52bb
Publikováno v:
Journal of Transport and Land Use, Vol 14, Iss 1 (2021)
Accurate evaluation of land value-added benefit brought by urban rail transit (URT) is critical for project investment decision making and value capture strategy development. Early studies have focused on the value impact strength under the assumptio
Externí odkaz:
https://doaj.org/article/22d0c4d213504404b8d1f7204569cf10
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254359 (2021)
Reopening amid the COVID-19 pandemic has triggered a battle on social media. The supporters perceived that the lockdown policy could damage the economy and exacerbate social inequality. By contrast, the opponents believed it was necessary to contain
Externí odkaz:
https://doaj.org/article/663047cc97c8497c8c114474253c20f1