Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Qingan Sun"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
The important tuberculosis drug pyrazinamide (PZA) is converted to its active form pyrazinoic acid (POA) in Mycobacterium tuberculosis (Mtb). Here the authors identify the pantothenate biosynthesis pathway enzyme aspartate decarboxylase (PanD) as the
Externí odkaz:
https://doaj.org/article/169473de3b71419aa5a136c2eae1f753
Publikováno v:
The European Physical Journal D. 76
Autor:
Steve A. Maxwell, Deeann Wallis, Nian Zhou, Dwight Baker, Seyed H. Mousavi-Fard, Kimberly Loesch, Stacy Galaviz, Liam Guthrie, Thomas Snavely, Qingan Sun, Carolina M. Rojas, David W. Threadgill, Thomas Ioerger, Wen Dong, Gwen Seemann, Theresa W. Fossum, James C. Sacchettini
Publikováno v:
Cancer Research. 82:410-410
Introduction: We have discovered novel non-toxic rifamycins that are extremely potent at sensitizing many drug-resistant cancers, including DLBCL, to standard-of-care chemotherapeutics. Methods: CHOP-resistant DLBCL cell lines were derived from CHOP-
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Pyrazinamide has been a mainstay in the multidrug regimens used to treat tuberculosis. It is active against the persistent, non-replicating mycobacteria responsible for the protracted therapy required to cure tuberculosis. Pyrazinamide is a pro-drug
Autor:
Xiaojun Li, Cai Jiang, Li-Wei Hung, Junjie Zhang, James C. Sacchettini, Qingan Sun, Kailu Yang
Publikováno v:
Structure. 23:1858-1865
SummaryThe ribosomal silencing factor RsfS slows cell growth by inhibiting protein synthesis during periods of diminished nutrient availability. The crystal structure of Mycobacterium tuberculosis (Mtb) RsfS, together with the cryo-electron microscop
Publikováno v:
Molecular Microbiology. 73:367-381
Mycobacteriophages encounter a unique problem among phages of Gram-positive bacteria, in that lysis must not only degrade the peptidoglycan layer but also circumvent a mycolic acid-rich outer membrane covalently attached to the arabinogalactan-peptid
Autor:
Amar Bir Singh Sidhu, Louis J. Nkrumah, Michael W. Dunne, Qingan Sun, James C. Sacchettini, David A. Fidock
Publikováno v:
Journal of Biological Chemistry. 282:2494-2504
Azithromycin (AZ), a broad-spectrum antibacterial macrolide that inhibits protein synthesis, also manifests reasonable efficacy as an antimalarial. Its mode of action against malarial parasites, however, has remained undefined. Our in vitro investiga
Autor:
James C. Sacchettini, Qingan Sun, Kimberly Loesch, Stacy Galaviz, Thomas R. Ioerger, Deeann Wallis, Michael A. DeJesus
Publikováno v:
Stem cells (Dayton, Ohio). 33(8)
We used a genomic library of mutant murine embryonic stem cells (ESCs) and report the methodology required to simultaneously culture, differentiate, and screen more than 3,200 heterozygous mutant clones to identify host-based genes involved in both s
Autor:
Fu-Jia Yang, Minqian Li, Jun Hu, Qingan Sun, Yibo Huang, Qingqing Wei, Zhihong Zhang, Lin Tang, Yi Zhang, Qingguo Li
Publikováno v:
Chinese Science Bulletin. 46:1897-1900
HalobacteriaH.sp.xz 515 was isolated from a salt lake in Tibet. Although proton release-and-uptake across claret membrane is in reverse order compared to bacteriorhodopsin in purple membrane fromHalobacterium Salinarum, and its efficiency of proton p
Publikováno v:
Chinese Science Bulletin. 45:1108-1113
The gene fragment encoding the retinal protein from helix C to helix G in a new strain of halobacteria, H.sp.xz515 has been amplified by PCR method. The nucleotide sequence of this fragment has been determined. The deduced amino acid sequence has bee