Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Qing-Yin Wang"'
Publikováno v:
Kybernetes, 2000, Vol. 29, Issue 9/10, pp. 1223-1233.
Externí odkaz:
http://www.emeraldinsight.com/doi/10.1108/03684920010346266
Autor:
Haoying Xu, Wei Lin Sandra Sim, Cheah Chen Seh, Feng Wang, Thierry T. Diagana, Wai Ling Chan, Jae-Geun Song, Kah Fei Wan, Bin Zou, Ghislain M. C. Bonamy, David Beer, David T. Barkan, Min Li, Stephanie A. Moquin, Francesca Blasco, Suresh B. Lakshminarayana, Jin Zhang, Oliver Simon, Vito G. Sasseville, Craig W. Day, Qing-Yin Wang, Chandrassegar Saravanan, Katherine Chan, Fumiaki Yokokawa, Bryan K. S. Yeung, Ratna Karuna, Hui-Quan Yeo, Colin Osborne, Christopher Sarko, Pei Yong Shi, Hongping Dong, Mei Ding, Siew Pheng Lim, Yen Liang Chen, Feng Gu, Cyrille Kounde, Gang Wang, Siyan Lu, Wei Liu
Publikováno v:
Science Translational Medicine. 13
Dengue virus (DENV) is a mosquito-borne flavivirus that poses a threat to public health, yet no antiviral drug is available. We performed a high-throughput phenotypic screen using the Novartis compound library and identified candidate chemical inhibi
Publikováno v:
In Aquaculture 2006 258(1):55-62
Autor:
Hongping Dong, Bryan K. S. Yeung, Ratna Karuna, Bin Zou, Trixie Wagner, Hui-Quan Yeo, Cyrille Kounde, Oliver Simon, Kah Fei Wan, Qing-Yin Wang, Ghislain M. C. Bonamy, Fumiaki Yokokawa, Ina Dix
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1385-1389
A series of 2-oxopiperazine derivatives were designed from the pyrrolopiperazinone cell-based screening hit 4 as a dengue virus inhibitor. Systematic investigation of the structure-activity relationship (SAR) around the piperazinone ring led to the i
Autor:
CongBao Kang, Jing Zou, Vsevolod L. Popov, Xuping Xie, Qing Yin Wang, Hongping Dong, Andrew Routh, Pei Yong Shi, Yiyang Zhou, Xianwen Zhang, Xinwen Chen
Publikováno v:
Cell hostmicrobe. 26(5)
Dengue virus assembly requires cleavage of viral C-prM-E polyprotein into three structural proteins (capsid, premembrane, and envelope), packaging of viral RNA with C protein into nucleocapsid, and budding of prM and E proteins into virions. The mole
Autor:
Michelle Yueqi Lee, Qing Yin Wang, Pei Yong Shi, CongBao Kang, Yan Li, Ying Lei Wong, Julien Lescar, Qingxin Li
Publikováno v:
Angewandte Chemie International Edition. 55:12068-12072
Dengue virus nonstructural protein 4B (NS4B) is a membrane protein consisting of 248 residues with a crucial role in virus replication and interference with the host innate immunity. The dengue virus serotype 3 NS4B was reconstituted into lyso-myrist
Autor:
Jing Zou, Le Tian Lee, Pei Yong Shi, CongBao Kang, Yan Li, Shovanlal Gayen, Qing Yin Wang, Qiwei Huang, Youngmee Kim, Julien Lescar, Ying Lei Wong, Xuping Xie
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1848:3150-3157
The transmembrane NS4B protein of dengue virus (DENV) is a validated antiviral target that plays important roles in viral replication and invasion of innate immune response. The first 125 amino acids of DENV NS4B are sufficient for inhibition of alph
Autor:
Julien Lescar, Feng Gu, Kah Fei Wan, Francesca Blasco, CongBao Kang, Wai Ling Chan, Wei Liu, Paul W. Smith, Agatha Susila, Bin Zou, Qing Yin Wang, K.L. Yeo, Mei Ding, Chao Shan, Andy M. Yip, Haoying Xu, Hongping Dong, Jing Zou, Suresh B. Lakshminarayana, Ratna Karuna, Pei Yong Shi, Peck Gee Seah
Publikováno v:
Journal of Virology. 89:8233-8244
The four serotypes of dengue virus (DENV-1 to -4) represent the most prevalent mosquito-borne viral pathogens in humans. No clinically approved vaccine or antiviral is currently available for DENV. Here we report a spiropyrazolopyridone compound that
Autor:
Zhiming Yuan, Qing Yin Wang, Lin-Lin Xu, Bo Zhang, Chao Shan, Cheng Lin Deng, Han-Qing Ye, Si Qing Liu, Bao Di Shang, Pei Yong Shi, Xiao-Dan Li
Publikováno v:
Journal of Virological Methods. 219:62-66
We report a stable Gaussia luciferase enterovirus 71 (Gluc-EV71) reporter virus to facilitate drug discovery. The Gluc-EV71 reporter virus was generated by engineering the Gaussia luciferase (Gluc) gene between the 5' untranslated region and VP4 gene
Publikováno v:
Antiviral Research. 118:39-45
The flavivirus nonstructural 4B protein (NS4B) has recently emerged as a valid antiviral target for drug discovery. Here we review (i) the current understanding of the structure and function of DENV NS4B, (ii) the approaches that have been taken to i