Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Qing-Wei Zhao"'
Publikováno v:
Synthetic and Systems Biotechnology, Vol 9, Iss 4, Pp 766-774 (2024)
The anti-Clostridium difficile infection (CDI) drug fidaxomicin is a natural polyketide metabolite mainly produced by Micromonosporaceae, such as Actinoplanes deccanensis, Dactylosporangium aurantiacum, and Micromonospora echinospora. In the present
Externí odkaz:
https://doaj.org/article/77bd29f45cf24682930b4e3df50f7cb0
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-11 (2024)
Abstract Background Human lysozyme (hLYZ) is a natural antibacterial protein with broad applications in food and pharmaceutical industries. Recombinant production of hLYZ in Komagataella phaffii (K. phaffii) has attracted considerable attention, but
Externí odkaz:
https://doaj.org/article/a3cbb10efe604a749ef3ff83c0f755c9
Autor:
Bing-Bing Ma, Chen-Fan Sun, Jing-Yi Zhou, Shuai-Lei Gu, Xin-Yi Dai, Yan-Zhen Chen, Qing-Wei Zhao, Xu-Ming Mao
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract Protein post-translational modifications (PTMs) with various acyl groups play central roles in Streptomyces. But whether these acyl groups can be further modified, and the influences of these potential modifications on bacterial physiology h
Externí odkaz:
https://doaj.org/article/5d8fd8237b3f4219bd0048eed7e6f80f
Autor:
Huang Xie, Jing-Yi Ruan, Qing-Ting Bu, Yue-Ping Li, Yi-Ting Su, Qing-Wei Zhao, Yi-Ling Du, Yong-Quan Li
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Fidaxomicin is an 18-membered glycosidic macrolide polyketide that was clinically used in the treatment of Clostridium difficile infection in 2011. Although the biosynthetic mechanism and pathway-specific regulator of fidaxomicin were well e
Externí odkaz:
https://doaj.org/article/aeb9e410ed2f4fc6931b851f294df1b3
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Streptomyces is renowned for its abundant production of bioactive secondary metabolites, but most of these natural products are produced in low yields. Traditional rational network refactoring is highly dependent on the comprehensive understanding of
Externí odkaz:
https://doaj.org/article/259895fa99534d2881dac35aeefbcdf8
Autor:
Wen-Li Gao, Jiao-Le Fang, Chen-Yang Zhu, Wei-Feng Xu, Zhong-Yuan Lyu, Xin-Ai Chan, Qing-Wei Zhao, Yong-Quan Li
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT DNA methylation is a defense that microorganisms use against extreme environmental stress, and improving resistance against environmental stress is essential for industrial actinomycetes. However, research on strain optimization utilizing DN
Externí odkaz:
https://doaj.org/article/c3b8cff9475640f4a6317dfbde912df3
Publikováno v:
Microbial Biotechnology, Vol 15, Iss 6, Pp 1852-1866 (2022)
Summary The metabolic flux of fatty acyl‐CoAs determines lipopeptide biosynthesis efficiency, because acyl donor competition often occurs from polyketide biosynthesis and homologous pathways. We used A40926B0 as a model to investigate this mechanis
Externí odkaz:
https://doaj.org/article/1637a97c99cf41909f8c7700d73dcacf
Autor:
Ying Hu, Qing-Wei Zhao, Zheng-Cai Wang, Qing-Qing Fang, He Zhu, Dong-Sheng Hong, Xing-Guang Liang, Dong Lou, Wei-Qiang Tan
Publikováno v:
Journal of International Medical Research, Vol 49 (2021)
Objective To investigate if co-transfection of human bone morphogenetic protein 2 (BMP-2, BMP2 ) and human fibroblast growth factor 2 (FGF2, FGF2 ) via chitosan nanoparticles promotes osteogenesis in human adipose tissue-derived stem cells (ADSCs) in
Externí odkaz:
https://doaj.org/article/d37350b4aa814e1ab50c7581cbeeddbc
Autor:
Kai Wang, Qing-Wei Zhao, Yi-Fan Liu, Chen-Fan Sun, Xin-Ai Chen, Richard Burchmore, Karl Burgess, Yong-Quan Li, Xu-Ming Mao
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Efficient genome editing is a prerequisite of genetic engineering in synthetic biology, which has been recently achieved by the powerful CRISPR/Cas9 system. However, the toxicity of Cas9, due to its abundant intracellular expression, has impeded its
Externí odkaz:
https://doaj.org/article/88708c90f79b428eb89de9acf840d666
Publikováno v:
Synthesis. 55:1844-1854
The synthesis of 1-(trifluoromethyl)alkenes through nickel-catalyzed alkylation/arylation of 1-chloro-3,3,3-trifluoroprop-1-ene (HCFO-1233zd) with alkyl/aryl zinc reagents and cobalt-catalyzed reductive cross-coupling between HCFO-1233zd and aryl bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c5aaff2db3717363f7970aeaec79750
https://doi.org/10.1055/a-2042-3720
https://doi.org/10.1055/a-2042-3720