Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Qing-Fang Miao"'
Autor:
Dan-dan Zhou, Xiao-tian Zhai, Lan-wen Zhang, Zi-hui Xie, Ying Wang, Yong-su Zhen, Rui-juan Gao, Qing-fang Miao
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-16 (2024)
Abstract Trophoblast cell surface antigen 2 (Trop2) is considered to be an attractive therapeutic target in cancer treatments. We previously generated a new humanized anti-Trop2 antibody named hIMB1636, and designated it as an ideal targeting carrier
Externí odkaz:
https://doaj.org/article/866f250ded27490cb3efdaeecc640bc5
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 12, Iss 2, Pp 232-242 (2022)
Folate receptor (FR) overexpression occurs in a variety of cancers, including pancreatic cancer. In addition, enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer. Furthermore, the occurrence of intensive desmoplasia causes a hypoxic mi
Externí odkaz:
https://doaj.org/article/0d8c6a37e6cb405aa83581ab880b38c0
Autor:
Dan-Dan Zhou, Wei-Qi Bai, Xiao-Tian Zhai, Li-Ping Sun, Yong-Su Zhen, Zhuo-Rong Li, Qing-Fang Miao
Publikováno v:
Military Medical Research, Vol 8, Iss 1, Pp 1-14 (2021)
Abstract Background Triple-negative breast cancer (TNBC) is the most aggressive subtype and occurs in approximately 15–20% of diagnosed breast cancers. TNBC is characterized by its highly metastatic and recurrent features, as well as a lack of spec
Externí odkaz:
https://doaj.org/article/668db17c21a04120abadf7d0bc030eeb
Autor:
Xin‐yue Hu, Rong Wang, Jie Jin, Xiu‐jun Liu, A‐long Cui, Lian‐qi Sun, Yan‐ping Li, Yi Li, Yu‐cheng Wang, Yong‐su Zhen, Qing‐fang Miao, Zhuo‐rong Li
Publikováno v:
Molecular Oncology, Vol 13, Iss 2, Pp 246-263 (2019)
Epidermal growth factor receptor (EGFR) is a rational target for cancer therapy, because its overexpression plays an important oncogenic role in a variety of solid tumors; however, EGFR‐targeted antibody–drug conjugate (ADC) therapy for esophagea
Externí odkaz:
https://doaj.org/article/af0f3ad65cc842fdab36310b0d24bbdb
Autor:
Yi-Bo, Du, Xiao-Fei, Wang, Xiu-Jun, Liu, Yi, Li, Qing-Fang, Miao, Min, Jiang, Wei-Jin, Sheng, Yong-Su, Zhen
Publikováno v:
Biochemical Pharmacology. 201:115057
KRAS mutation and NF-κB both play crucial role in pancreatic cancer; in addition, defensin, the peptide mediator in innate immunity, can inhibit NF-κB. Assuming a strategy that targets both NF-κB and concomitantly the mutated KRAS indirectly via i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14457196f65138d737aa6c46363816ce
https://doi.org/10.1016/j.bcp.2022.115057
https://doi.org/10.1016/j.bcp.2022.115057
Publikováno v:
Anti-Cancer Drugs. 18:127-137
Single-domain antibodies are attractive as tumor-targeting vehicles because of their much smaller size than intact antibody molecules. Lidamycin is a macromolecular antitumor antibiotic, which consists of a labile enediyne chromophore (AE) and a nonc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e24b41220d12b5c4a6bc134e0d96aa
https://doi.org/10.1097/cad.0b013e3280112779
https://doi.org/10.1097/cad.0b013e3280112779
Publikováno v:
Yao xue xue bao = Acta pharmaceutica Sinica. 47(10)
The use of monoclonal antibodies (mAbs) for cancer therapy has achieved considerable success in recent years. Approximate 17 monoclonal antibodies have been approved as cancer therapeutics since 1997. Antibody-drug conjugates (ADC) are powerful new t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5e27dfaee543da80269e4a072ba3813
https://pubmed.ncbi.nlm.nih.gov/23289136
https://pubmed.ncbi.nlm.nih.gov/23289136
Publikováno v:
Yao xue xue bao = Acta pharmaceutica Sinica. 44(6)
Recent studies have shown that epidermal growth factor receptor (EGFR) is an important target for cancer therapy. The present study prepared single chain Fv (scFv) directed against EGFR. Balb/c mice were immunized by human carcinoma A431 cells, and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::575d35a9c7e6335097374c936b9feea4
https://pubmed.ncbi.nlm.nih.gov/19806889
https://pubmed.ncbi.nlm.nih.gov/19806889
Publikováno v:
Zhonghua yi xue za zhi. 89(20)
To study the effect of anti-type IV collagenase single-chain antibody scFv (3G11) on bleomycin (BLM)-induced pulmonary fibrosis.C57BL/6 mice were divided into six groups (blank, saline control, BLM, low-dose treatment, intermediate-dose treatment, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50f5515c7ebc99d6659675defe8b3b61
https://pubmed.ncbi.nlm.nih.gov/19671337
https://pubmed.ncbi.nlm.nih.gov/19671337
Publikováno v:
Ai zheng = Aizheng = Chinese journal of cancer. 28(6)
Epidermal growth factor receptor (EGFR) is abnormally overexpressed on many kinds of tumor cells. Lidamycin is an enediyne antibiotic with highly potent antitumor activity. This study was to construct a novel fusion protein by recombining EGFR specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e2118eb8d83418fc330c31aed81f942
https://pubmed.ncbi.nlm.nih.gov/19635191
https://pubmed.ncbi.nlm.nih.gov/19635191