Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Qing-Dong Wang"'
Autor:
Alena Ivanova, Franziska Kohl, Hernán González-King Garibotti, Renata Chalupska, Aleksander Cvjetkovic, Mike Firth, Karin Jennbacken, Sofia Martinsson, Andreia M. Silva, Ida Viken, Qing-Dong Wang, John Wiseman, Niek Dekker
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Heart failure remains a leading cause of mortality. Therapeutic intervention for heart failure would benefit from targeted delivery to the damaged heart tissue. Here, we applied in vivo peptide phage display coupled with high-throughput Next
Externí odkaz:
https://doaj.org/article/9f8a56535f58403fa172c838efb781c1
Autor:
Laura A. Woo, Kaitlyn L. Wintruba, Bethany Wissmann, Svyatoslav Tkachenko, Ewa Kubicka, Emily Farber, Ola Engkvist, Ian Barrett, Kenneth L. Granberg, Alleyn T. Plowright, Matthew J. Wolf, David L. Brautigan, Stefan Bekiranov, Qing-Dong Wang, Jeffrey J. Saucerman
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110485- (2024)
Summary: Mammalian hearts lose their regenerative potential shortly after birth. Stimulating the proliferation of preexisting cardiomyocytes is a potential therapeutic strategy for cardiac damage. In a previous study, we identified 30 compounds that
Externí odkaz:
https://doaj.org/article/1bf1716420a649368af21109efc59278
Autor:
Hernán González‐King, Patricia G. Rodrigues, Tamsin Albery, Benyapa Tangruksa, Ramya Gurrapu, Andreia M. Silva, Gentian Musa, Dominika Kardasz, Kai Liu, Bengt Kull, Karin Åvall, Katarina Rydén‐Markinhuhta, Tania Incitti, Nitin Sharma, Cecilia Graneli, Hadi Valadi, Kasparas Petkevicius, Miguel Carracedo, Sandra Tejedor, Alena Ivanova, Sepideh Heydarkhan‐Hagvall, Phillipe Menasché, Jane Synnergren, Niek Dekker, Qing‐Dong Wang, Karin Jennbacken
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 5, Pp n/a-n/a (2024)
Abstract Small extracellular vesicles (sEV) derived from various cell sources have been demonstrated to enhance cardiac function in preclinical models of myocardial infarction (MI). The aim of this study was to compare different sources of sEV for ca
Externí odkaz:
https://doaj.org/article/c768354e5bb04d27b8a38ee892355c5b
Autor:
Francesca Del Gaudio, Dongli Liu, Maarja Andaloussi Mäe, Eike-Benjamin Braune, Emil M. Hansson, Qing-Dong Wang, Christer Betsholtz, Urban Lendahl
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The heart depends on a functional vasculature for oxygenation and transport of nutrients, and it is of interest to learn how primary impairment of the vasculature can indirectly affect cardiac function and heart morphology. Notch3-deficiency
Externí odkaz:
https://doaj.org/article/12b2410e4eda4271b1548e478b597290
Autor:
Xiuxiu Liu, Maoying Han, Wendong Weng, Yan Li, Wenjuan Pu, Kuo Liu, Xufeng Li, Lingjuan He, Ruilin Sun, Ruling Shen, Yulong He, Dandan Liang, Yi-Han Chen, Qing-Dong Wang, Jan S. Tchorz, Bin Zhou
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-7 (2023)
Abstract A genetic system, ProTracer, has been recently developed to record cell proliferation in vivo. However, the ProTracer is initiated by an infrequently used recombinase Dre, which limits its broad application for functional studies employing f
Externí odkaz:
https://doaj.org/article/003857d550184788a930ee3f005fbb6c
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 39, Iss 4, Pp 354-363 (2023)
Abstract Laryngeal cancer is a usual malignant tumor of the head and neck. The role and mechanism of deubiquitinase USP21 in laryngeal cancer are still unclear. We aimed to explore whether USP21 affected laryngeal cancer progress through deubiquitina
Externí odkaz:
https://doaj.org/article/7595d0b391de41df85f1b4fb316083c6
Autor:
Qing-Dong Wang, Li-Xin Guo
Publikováno v:
Journal of Materials Science: Materials in Medicine, Vol 33, Iss 6, Pp 1-13 (2022)
Abstract Under whole body vibration, how the cement augmentation affects the vibration characteristic of the osteoporotic fusion lumbar spine, complications, and fusion outcomes is unclear. A L1-L5 lumbar spine finite element model was developed to s
Externí odkaz:
https://doaj.org/article/0539087e5ba6421380ac326a9faa65c7
Autor:
Xiuxiu Liu, Wenjuan Pu, Lingjuan He, Yan Li, Huan Zhao, Yi Li, Kuo Liu, Xiuzhen Huang, Wendong Weng, Qing-Dong Wang, Linghong Shen, Tao Zhong, Kun Sun, Reza Ardehali, Ben He, Bin Zhou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The adult mammalian heart exhibits stubbornly low levels of cardiomyocyte proliferation, leading to high morbidity after injury or heart attack. Here the authors develop an approach for tracking cardiomyocyte cell cycling and show that the majority a
Externí odkaz:
https://doaj.org/article/9b8cfcb5d01c4d9e967a80999d728db7
Autor:
Niels Grote Beverborg, Daniela Später, Ralph Knöll, Alejandro Hidalgo, Steve T. Yeh, Zaher Elbeck, Herman H. W. Silljé, Tim R. Eijgenraam, Humam Siga, Magdalena Zurek, Malin Palmér, Susanne Pehrsson, Tamsin Albery, Nils Bomer, Martijn F. Hoes, Cornelis J. Boogerd, Michael Frisk, Eva van Rooij, Sagar Damle, William E. Louch, Qing-Dong Wang, Regina Fritsche-Danielson, Kenneth R. Chien, Kenny M. Hansson, Adam E. Mullick, Rudolf A. de Boer, Peter van der Meer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Heart failure is a major cause of morbidity and mortality worldwide. Here the authors show that subcutaneous administration of antisense oligonucleotides targeting PLN is an effective strategy in preclinical models of genetic cardiomyopathy and ische
Externí odkaz:
https://doaj.org/article/fe3711b0c9be44609d25d2ed5e1f2344
Autor:
Lauren Drowley, Jane McPheat, Anneli Nordqvist, Samantha Peel, Ulla Karlsson, Sofia Martinsson, Erik Müllers, Anita Dellsén, Sinead Knight, Ian Barrett, José Sánchez, Björn Magnusson, Boris Greber, Qing‐Dong Wang, Alleyn T. Plowright
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 1, Pp 47-60 (2020)
Abstract Identification of small molecules with the potential to selectively proliferate cardiac progenitor cells (CPCs) will aid our understanding of the signaling pathways and mechanisms involved and could ultimately provide tools for regenerative
Externí odkaz:
https://doaj.org/article/b6628f3b0dc64ed6a5abbc6a43d40735