An integrated benefit-risk assessment of cobalt-containing alloys used in medical devices: Implications for regulatory requirements in the European Union

Autor: James Scutti, Mehran Bashiri, Jared T. Wilsey, Gary Eichenbaum, Brenda Faiola, Bob Hastings, Gion Fessel, Jorge Sague, Natalie S. Egnot, Laurence B. Katz, K. Connor, Millie Calistri-Yeh, John Wright, Qing-Qing Qiu, Mark Vreeke, Laura E.L. Perkins, Kenneth M. Unice, Andrew D. Monnot, Bushan Purushothaman, Stephen Marcello, Jim Nevelos, Jesper Christensen, Sharlee L. More, Whitney V. Christian, Paul Coplan, Michael Kovochich, Philippe Hasgall

Publikováno v: Regulatory Toxicology and Pharmacology. 125:105004

In 2017, the European Union (EU) Committee for Risk Assessment (RAC) recommended the classification of metallic cobalt (Co) as Category 1B with respect to its carcinogenic and reproductive hazard potential and Category 2 for mutagenicity but did not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29126ed07a58349e0052be1bd9752c63
https://doi.org/10.1016/j.yrtph.2021.105004

Synthesis, activity evaluation, and pro-apoptotic properties of novel 1,2,4-triazol-3-amine derivatives as potent anti-lung cancer agents

Autor: Cheng-Hao Jin, Zhen-Wang Li, Chun-Yan Zhong, Xin Wang, Qing-Qing Qiu, Mei-Yu Liu, Xian-Yu Sun

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1210-1217 (2019)

In this study, a series of 4,5-bis(substituted phenyl)-4H-1,2,4-triazol-3-amine compounds was designed, synthesised, and evaluated to determine their potential as anti-lung cancer agents. According to the results of screening of lung cancer cell line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86140935d3ac3c9474f57da4ec21fa8d

MiRNA-199a-3p: A potential circulating diagnostic biomarker for early gastric cancer

Autor: Qu Cai, Jian Fang Li, Chen Li, Zheng Gang Zhu, Bing Ya Liu, Min Yan, Qing Qing Qiu

Publikováno v: Journal of Surgical Oncology. 108:89-92

Background Tumor-associated miRNAs have been detected in serum or plasma. We investigated whether plasma miRNA-199a-3p could be a potential circulating biomarker for early gastric cancer (EGC). Methods By using real-time qRT-PCR, the expression of mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7d92aa0f7315c7e3c88faa7c576b26b
https://doi.org/10.1002/jso.23358

Effects of e-beam radiation, storage, and hydration on osteoinductivity of DBM/AM composite

Autor: Jerome Connor, Xiang-Hong Liu, Qing-Qing Qiu

Publikováno v: Journal of Biomedical Materials Research Part B: Applied Biomaterials. :401-408

E-beam irradiation is often used to sterilize medical devices including demineralized bone matrix (DBM) products. In this study, the effect of e-beam on osteoinductivity of a DBM product in hydrous and anhydrous configurations has been evaluated at 0

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52e08d8af5839472b737be2db698b56
https://doi.org/10.1002/jbm.b.31415

Effects of γ-irradiation, storage and hydration on osteoinductivity of DBM and DBM/AM composite

Autor: Jerome Connor, Qing-Qing Qiu

Publikováno v: Journal of Biomedical Materials Research Part A. :373-379

This study investigated the effect of gamma-irradiation dose, irradiation temperature, hydration and storage condition on osteoinductivity of demineralized bone matrix (DBM) and demineralized bone matrix/acellular dermal matrix (DBM/AM) composite. DB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f084a257821c7cc6968d8900a2db5298
https://doi.org/10.1002/jbm.a.31790