Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Qing‐zhang Tuo"'
Autor:
Bin Du, Zijie Deng, Kang Chen, Zhangzhong Yang, Junfen Wei, Liuyao Zhou, Jie Meng, Ying Cheng, Xin Tian, Qing-Zhang Tuo, Peng Lei
Publikováno v:
Genes and Diseases, Vol 11, Iss 6, Pp 101262- (2024)
Programmed cell death contributes to neurological damage in ischemic stroke, especially during the reperfusion stage. Several cell death pathways have been tested preclinically and clinically, including ferroptosis, necroptosis, and apoptosis. Howeve
Externí odkaz:
https://doaj.org/article/115cdc8e8bd14f209f86ba002b162029
Autor:
Xulong Ding, Shuqiang Cao, Qing Wang, Bin Du, Kefeng Lu, Shiqian Qi, Ying Cheng, Qing‐zhang Tuo, Weibo Liang, Peng Lei
Publikováno v:
Advanced Science, Vol 11, Iss 15, Pp n/a-n/a (2024)
Abstract Traumatic brain injury (TBI) leads to progressive neurodegeneration that may be caused by chronic traumatic encephalopathy (CTE). However, the precise mechanism remains unclear. Herein, the study identifies a crucial protein, axonemal dynein
Externí odkaz:
https://doaj.org/article/dad6cfb7be6046d38db561fec56cf9c2
Publikováno v:
Translational Oncology, Vol 39, Iss , Pp 101817- (2024)
Ferroptosis is a recently identified form of regulated cell death that plays a crucial role in tumor suppression. In this study, we found that F2 (the gene encoding thrombin) was strongly upregulated in breast cancer (BRCA, TCGA Study Abbreviations)
Externí odkaz:
https://doaj.org/article/fd69f5ad9c8b4083b0aa6cad10ef23e9
Autor:
Kang Chen, Fei Tang, Bin Du, Zhe‐Zhou Yue, Ling‐Ling Jiao, Xu‐Long Ding, Qing‐Zhang Tuo, Jie Meng, Si‐Yu He, Lunzhi Dai, Peng Lei, Xia‐Wei Wei
Publikováno v:
MedComm, Vol 4, Iss 6, Pp n/a-n/a (2023)
Abstract Mutations in LRRK2 (encoding leucine‐rich repeat kinase 2 protein, LRRK2) are the most common genetic risk factors for Parkinson's disease (PD), and increased LRRK2 kinase activity was observed in sporadic PD. Therefore, inhibition of LRRK
Externí odkaz:
https://doaj.org/article/32e62c3f8e794c19a0b5ef7bb8bcde66
Autor:
Qing-zhang Tuo, Yu Liu, Zheng Xiang, Hong-Fa Yan, Ting Zou, Yang Shu, Xu-long Ding, Jin-jun Zou, Shuo Xu, Fei Tang, Yan-qiu Gong, Xiao-lan Li, Yu-jie Guo, Zhao-yue Zheng, Ai-ping Deng, Zhang-zhong Yang, Wen-jing Li, Shu-ting Zhang, Scott Ayton, Ashley I. Bush, Heng Xu, Lunzhi Dai, Biao Dong, Peng Lei
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-15 (2022)
Abstract Ischemic stroke represents a significant danger to human beings, especially the elderly. Interventions are only available to remove the clot, and the mechanism of neuronal death during ischemic stroke is still in debate. Ferroptosis is incre
Externí odkaz:
https://doaj.org/article/3a1ccb6e681447169bc0baefbc281542
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-16 (2021)
Abstract Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis, autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by the accumulation of lethal lipid species derived from the
Externí odkaz:
https://doaj.org/article/403105b6b3004967af8f9e9d3e82f04e
Publikováno v:
Journal of Neurochemistry. 165:487-520
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6a236c4e79e82d31c0dcae84b49924d
https://doi.org/10.1111/jnc.15807
https://doi.org/10.1111/jnc.15807
Autor:
Jinyuan Luoqian, Wenyong Yang, Xulong Ding, Qing-zhang Tuo, Zheng Xiang, Zhaoyue Zheng, Yu-jie Guo, Li Li, Pengbo Guan, Scott Ayton, Biao Dong, Huiyuan Zhang, Hongbo Hu, Peng Lei
Publikováno v:
Cellular & Molecular Immunology. 19:913-924
While many drugs are effective at reducing the relapse frequency of multiple sclerosis (MS), there is an unmet need for treatments that slow neurodegeneration resulting from secondary disease progression. The mechanism of neurodegeneration in MS has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3175913c10ece40486eeacec0f77453
https://doi.org/10.1038/s41423-022-00883-0
https://doi.org/10.1038/s41423-022-00883-0
Autor:
Shashank Masaldan, Abdel A. Belaidi, Scott Ayton, Celeste H. Mawal, Peng Lei, Qing-Zhang Tuo, Ashley I. Bush, Adam Southon
Publikováno v:
Neurotherapeutics
The emergence of ferroptosis as a cell death pathway associated with brain disorders including stroke and neurodegenerative diseases emphasizes the need to develop therapeutics able to target the brain and to protect neurons from ferroptotic death. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebfe8564d2ee73991b34103f3bd1952
https://doi.org/10.1007/s13311-021-01111-9
https://doi.org/10.1007/s13311-021-01111-9
Publikováno v:
Journal of Alzheimer's Disease. 80:1353-1362
The detection of plasma tau and its phosphorylation is technically challenging due to the relatively low sensitivity. However, in Alzheimer’s disease and other tauopathies, it is hypothesized that tau in the biofluid may serve as a biomarker. In re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724e929a57d3ea54ef29a1a3c3de0606
https://doi.org/10.3233/jad-201499
https://doi.org/10.3233/jad-201499