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Akademický článek

Trends and projections of inflammatory bowel disease at the global, regional and national levels, 1990–2050: a bayesian age-period-cohort modeling study

Autor: Jia-Li Zhou, Jia-Chen Bao, Xu-Ying Liao, Yi-Jia Chen, Lin-Wei Wang, Yan-Yun Fan, Qin-Yu Xu, Lan-Xiang Hao, Kun-Jian Li, Ming-Xian Liang, Tian-Hui Hu, Zheng-Jin Liu, Yi-Qun Hu

Publikováno v: BMC Public Health, Vol 23, Iss 1, Pp 1-12 (2023)

Abstract Background Inflammatory bowel disease (IBD) is a global health concern with varying levels and trends across countries and regions. Understanding these differences is crucial for effective prevention and treatment strategies. Methods Using d

Externí odkaz: https://doaj.org/article/edfd707e6f7e41a7a189b4d60e1c3c94

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Akademický článek

TREM2 promotes the proliferation and invasion of renal cell carcinoma cells by inhibiting the P53 signaling pathway.

Autor: LIANG ZHANG, ZHONG LV, QIN-YU XU, BIN WU

Publikováno v: Oncology Letters; Nov2024, Vol. 28 Issue 5, p1-9, 9p

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Obesity-Induced Upregulation of ZBTB7A Promotes Lipid Accumulation through SREBP1

Autor: Mei-Ya Chen, Yang Song, Jing-Jing Liu, Yan-Dan Ren, Fei Zhou, Li-Gang Chen, Jing-ping Zhou, Jin-Shui Pan, Qin-yu Xu

Publikováno v: BioMed Research International
BioMed Research International, Vol 2020 (2020)

Objective. Nonalcoholic fatty liver disease (NAFLD) is among the most common chronic liver diseases. However, the pathogenesis of NAFLD is not still unclear. This study aims at evaluating the role of zinc finger and BTB domain-containing 7A (ZBTB7A)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22001bf7ec773665d8c9dcc217aebad

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Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease

Autor: Hui-Min Wu, Jing Hua, Wenjing Luo, Qi Wang, Qin-Yu Xu

Publikováno v: Scientific Reports

Abnormal lipid-mediated hepatic inflammatory-immune dysfunction and chronic low grade inflammation play an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Macrophage polarization is an important mechanism for the regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9923505c217c3fba51346ace2a8a8a89
https://pubmed.ncbi.nlm.nih.gov/28300213

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Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation

Autor: Wenjing Luo, Yongheng Sui, Qin-Yu Xu, Jing Hua

Publikováno v: World journal of gastroenterology. 22(8)

To investigate the effect of different dietary fatty acids on hepatic inflammasome activation.Wild-type C57BL/6 mice were fed either a high-fat diet or polyunsaturated fatty acid (PUFA)-enriched diet. Primary hepatocytes were treated with either satu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab20af8ae0b38ba35e3fb5c7c622f0cc
https://pubmed.ncbi.nlm.nih.gov/26937141

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Aggregation of IGF-1 receptors or insulin receptors and activation of their kinase activity are simultaneously caused by the presence of polycations or K-ras basic peptides

Autor: Yoko Fujita-Yamaguchi, Thomas R. Lebon, Shu Lian Li, Qin Yu Xu

Publikováno v: Biochemistry. 30:11811-11819

Several groups including us reported that basic proteins and polycations activate the insulin receptor tyrosine-specific protein kinase (TPK) in vitro. However, some inconsistency has become obvious in the observations. The most intriguing was the br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fe94ad6f5caec239ef192713a1b1268
https://doi.org/10.1021/bi00115a011

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Substructural analysis of the insulin receptor by microsequence analyses of limited tryptic fragments isolated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis in the absence or presence of dithiothreitol

Autor: Qin-Yu Xu, Yoko Fujita-Yamaguchi, Raymond J. Paxton

Publikováno v: Journal of Biological Chemistry. 265:18673-18681

Human placental insulin receptor contains 47 Cys per an alpha beta dimer. Most of the 94 Cys in an intact alpha 2 beta 2 receptor are expected to form interchain or intrachain disulfide bonds, since there appears to be only one free cysteine residue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a22f38539346b432f9f7a35d4e0be9ca
https://doi.org/10.1016/s0021-9258(17)44805-8

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Microsequence Analysis of Proteins: Application to Substructural Studies on the Insulin Receptor

Autor: John E. Shively, Yoko Fujita-Yamaguchi, Raymond J. Paxton, Qin-Yu Xu

Publikováno v: Retrospect and Prospect of Protein Research ISBN: 9789810205188
Retrospect and Prospect of Protein Research: Festschrift in Honour of Professor Cao Tianqin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c199a8a9e3fcaef0c1b3390d63d6142
https://doi.org/10.1142/9789814360425_0025

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Microsequence analysis of peptides and proteins

Autor: John E. Shively, Qin-Yu Xu

Publikováno v: Analytical Biochemistry. 170:19-30

We have quantitatively examined the various parameters affecting the electrotransfer and sequence analysis of proteins from sodium dodecyl sulfate (SDS) gels to derivatized glass fiber paper or to polyvinyldifluoride (PVDF) membranes. Transfer yields

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17e90d67ea7ab5e2bbe830f547ed2ec1
https://doi.org/10.1016/0003-2697(88)90084-x

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