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Data from Inactivation of DNA-Dependent Protein Kinase Leads to Spindle Disruption and Mitotic Catastrophe with Attenuated Checkpoint Protein 2 Phosphorylation in Response to DNA Damage

Autor: Ping-Kun Zhou, Yu Wang, Xiao-Dan Liu, Rong Fan, Shi-Meng Zhang, Qin-Zhi Xu, Bo Huang, Zeng-Fu Shang

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is well known as a critical component involving the nonhomologous end joining pathway of DNA double-strand breaks repair. Here, we showed another important role of DNA-PKcs in stabilizing spin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014af8f94426e9ae46175c6c26207a15
https://doi.org/10.1158/0008-5472.c.6501594

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Baicalin exerts protective effects against lipopolysaccharide-induced acute lung injury by regulating the crosstalk between the CX3CL1-CX3CR1 axis and NF-κB pathway in CX3CL1-knockout mice

Autor: Qin-Zhi Xu, Yong Wang, Lei Pan, Xin-Min Ding

Publikováno v: International Journal of Molecular Medicine

Acute lung injury (ALI) as a serious diseases with high mortality and is considered a threat to human health and life. A number of studies have focused on the treatment and prevention of lung injury. However, the molecular mechanisms responsible for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8970cf7f2b98683fb8ee4483e379c507
https://doi.org/10.3892/ijmm.2016.2456

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TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1

Autor: Man Song, Cai Gao Zhong, Lan Yu, Lian Hong Zou, Yu Wang, Zeng Fu Shang, Hua Guan, Ping-Kun Zhou, Xiao-Dan Liu, Shi Meng Zhang, Wei Tan, Qin Zhi Xu

Publikováno v: Oncotarget

// Lian-Hong Zou 1, 2 , Zeng-Fu Shang 2, 3 , Wei Tan 1, 2 , Xiao-Dan Liu 2 , Qin-Zhi Xu 2 , Man Song 2, 3 , Yu Wang 2 , Hua Guan 2 , Shi-Meng Zhang 2 , Lan Yu 4 , Cai-Gao Zhong 1 , Ping-Kun Zhou 2, 3 1 School of Public Heath, Central South University

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb50f4d5faeb4b47c507668a80ae90c
http://europepmc.org/articles/PMC4466666

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PIG3 Functions in DNA Damage Response through Regulating DNA-PKcs Homeostasis

Autor: Yu Wang, Bing Li, Zeng Fu Shang, Xiao-Dan Liu, Jiao Jiao Yin, Hua Guan, Ping-Kun Zhou, Shi Meng Zhang, Qin Zhi Xu

Publikováno v: International Journal of Biological Sciences

The p53-inducible gene 3 (PIG3) recently has been reported to be a new player in DNA damage signaling and response, but the crucial mechanism remains unclear. In the present study, the potential mechanism of PIG3 participation in the DNA damage respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648d2249ed11f9b71f22fcdebe220309
https://doi.org/10.7150/ijbs.6068

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