Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Qin C. Ryan"'
Autor:
Ivana Gojo, Qin C. Ryan, Edward A. Sausville, Alex Sparreboom, Milin Acharya, William D. Figg, Jűrgen Venitz, Judith E. Karp, Kyunghwa Hwang
Publikováno v:
Investigational New Drugs. 24:367-375
Aims: To evaluate elimination pathways of the histone deacetylase inhibitor MS-275 in vitro and screen for relationships between demographic factors that may affect its pharmacokinetics in vivo. Patients and Methods: Substrate specificity of MS-275 f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72ca181647ffa0b9bb275ed51357570
https://doi.org/10.1007/s10637-005-5707-6
https://doi.org/10.1007/s10637-005-5707-6
Autor:
Erin R. Gardner, Kyunghwa Hwang, Alice P. Chen, Martin Gutierrez, Kim Maynard, James H. Doroshow, Barbara A. Conley, Jane B. Trepel, Min-Jung Lee, Qin C. Ryan, Anthony J. Murgo, James A. Zwiebel, Giovanni Melillo, William D. Figg, Erin E. Donovan, Mikhail Kalnitskiy, Shivaani Kummar, Eun Joo Chung
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 13(18 Pt 1)
Purpose: MS-275 is a histone deacetylase inhibitor that has shown potent and unique anticancer activity in preclinical models. The aims of this phase I trial were to determine the dose-limiting toxicities and maximum tolerated dose of oral MS-275 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b860177b7f33a01a8b2bd788b356b738
https://pubmed.ncbi.nlm.nih.gov/17875771
https://pubmed.ncbi.nlm.nih.gov/17875771
Autor:
William D. Figg, James A. Zwiebel, Alex Sparreboom, Yusri A. Elsayed, Jane B. Trepel, Joseph Z. Ye, Edward A. Sausville, Manish Monga, Donna Headlee, Anthony J. Murgo, Giovanni Melillo, Mikhail Kalnitskiy, Milin Acharya, Eun Joo Chung, Kyunghwa Hwang, Qin C. Ryan
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 23(17)
Purpose The objective of this study was to define the maximum-tolerated dose (MTD), the recommended phase II dose, the dose-limiting toxicity, and determine the pharmacokinetic (PK) and pharmacodynamic profiles of MS-275. Patients and Methods Patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067a8c843b92136871814834e15306fe
https://pubmed.ncbi.nlm.nih.gov/15851766
https://pubmed.ncbi.nlm.nih.gov/15851766
Autor:
Richard F. Little, John D. Nguyen, Jorge A. Carrasquillo, Clara C. Chen, Qin C. Ryan, Wyndham H. Wilson
Publikováno v:
Clinical Nuclear Medicine. 28:979-980
Physiological fluorodeoxyglucose (FDG) uptake can obscure underlying disease or can even falsely suggest disease in patients undergoing whole-body positron emission tomography (PET) scanning for disease staging. Myocardial uptake in particular can pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e648094edfc9c6c9b7f9d28dde63871
https://doi.org/10.1097/01.rlu.0000099808.30653.06
https://doi.org/10.1097/01.rlu.0000099808.30653.06
Publikováno v:
Experimental cell research. 199(2)
Lymphocytes have a finite and predictable proliferative life span in culture similar to that observed in fibroblasts. In general, the senescence of human fibroblasts is inevitable and irreversible, but their proliferative life span can be extended by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1473330ab537e95593ac714fac35cf62
https://pubmed.ncbi.nlm.nih.gov/1544379
https://pubmed.ncbi.nlm.nih.gov/1544379
Autor:
Qin C. Ryan, E. A. Donovan, Milin Acharya, Barbara A. Conley, K. Maynard, Eun Joo Chung, Anthony J. Murgo, Edward A. Sausville, Jane B. Trepel, Giovanni Melillo
Publikováno v:
Journal of Clinical Oncology. 23:3094-3094
3094 Background: MS-275, a synthetic benzamide derivative, is a histone deacetylase (HDAC) inhibitor with in vitro & in vivo antitumor activity. Based on our q2 week dosing results, we explored max...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::097ca29b08d7b7420431593db9e20f88
https://doi.org/10.1200/jco.2005.23.16_suppl.3094
https://doi.org/10.1200/jco.2005.23.16_suppl.3094