Zobrazeno 1 - 10 of 83 pro vyhledávání: '"Qin C Ji"'
1
Signature peptide selection workflow for biomarker quantification using LC–MS-based targeted proteomics
Autor: Xiazi I Qiu, Kenneth J Ruterbories, Qin C Ji, Gary J Jenkins
Publikováno v: Bioanalysis. 15:295-300
In contrast to quantification of biotherapeutics, endogenous protein biomarker and target quantification using LC–MS based targeted proteomics can require a much more stringent and time-consuming tryptic signature peptide selection for each specifi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f46c99ba09544003642a8a61205c46b
https://doi.org/10.4155/bio-2022-0241
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2
Integrity and efficiency: AbbVie’s journey of building an integrated nonregulated bioanalytical laboratory
Autor: Yue-Ting Wang, Estelle M Maes, Lance Heinle, Kenneth Ruterbories, Stella Doktor, Mary Larsen, Amanda Olson, Andrew Lee, Cecilia Van Handel, Qin C Ji, Kelly Desino, Gary J Jenkins
Publikováno v: Bioanalysis. 15:161-176
While bioanalytical outsourcing is widely adopted in the pharmaceutical industry, AbbVie is one of the few large biopharmaceutical companies having an internal bioanalytical unit to support nearly all its drug metabolism and pharmacokinetic studies.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3cc1920e916d06bb8a99047c4a10df06
https://doi.org/10.4155/bio-2023-0012
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4
Use of in-sample calibration curve approach for quantification of peptides with high-resolution mass spectrometry
Autor: Soumya Kandi, John P. Savaryn, Qin C. Ji, Gary J. Jenkins
Publikováno v: Rapid communications in mass spectrometry : RCMREFERENCES. 36(22)
The in-sample calibration curve (ISCC) approach of quantification utilizes the response of isotopologue ions from spiked-in stable isotope labeled internal standard (SIL-IS) to build a standard curve. The quantitative analysis of the study sample is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64acd590ecba5e9f3ffa46f544db197
https://pubmed.ncbi.nlm.nih.gov/35940586
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6
A bridging immunogenicity assay for anti-cabiralizumab antibodies: overcoming the low assay cut point and drug tolerance challenges
Autor: Qin C Ji, Long Yuan, Li Li, Carol Gleason, Jim X Shen, Dennis Stocker
Publikováno v: Bioanalysis. 13:395-407
Background: To support the clinical studies of cabiralizumab, an immunogenicity assay for detecting anti-cabiralizumab antibodies is required. Results: Strategies were developed to overcome two major bioanalytical challenges: poor drug tolerance of t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a6e2a37fca229831c6b2623b89d261
https://doi.org/10.4155/bio-2020-0300
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7
Challenges and recommendations in developing LC–MS/MS bioanalytical assays of labile glucuronides and parent compounds in the presence of glucuronide metabolites
Autor: Qin C Ji, Xiaohui Xu, Long Yuan
Publikováno v: Bioanalysis. 12:615-624
Glucuronides, especially acyl glucuronides, were often found to be unstable in vitro and in vivo. Acyl glucuronide metabolites can convert back to the parent drugs at physiological pH through hydrolysis. Glucuronides can also undergo in-source fragme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d7ebe64596dc378f7351083e9d7dd7
https://doi.org/10.4155/bio-2020-0055
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8
Comparison of three parallelism assessment methods of biomarker quantification by LC-MS/MS: a case study of the bioanalysis of creatinine in human urine samples
Autor: Xiazi I Qiu, John P Savaryn, Kenneth J Ruterbories, Qin C Ji, Gary Jenkins
Publikováno v: Bioanalysis. 14(5)
Background: Currently, no regulatory guidelines are available for parallelism assessment for LC-MS biomarker quantification. Spike recovery, standard addition and dilutional linearity are recommended with no mention of the implications of applying th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ffc8115ca01b6afa3cd8e4f7f615476
https://pubmed.ncbi.nlm.nih.gov/35188423
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9
A convenient strategy to overcome interference in LC-MS/MS analysis: Application in a microdose absolute bioavailability study
Autor: Li Zhu, Alban Allentoff, Christine Huang, Long Yuan, Kimberly Voronin, Renuka Pillutla, Peggy Liu-Kreyche, Naiyu Zheng, R. Marcus Fancher, Ramaswamy A. Iyer, Qin C Ji
Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 165:198-206
Stable isotope labeled (SIL) compounds have been commonly used as internal standards (IS) to ensure the accuracy and quality of liquid chromatography–mass spectrometry (LC–MS) bioanalytical assays. Recently, the application of SIL drugs and LC–
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fc68cf12dfa694920138ee93092ab9
https://doi.org/10.1016/j.jpba.2018.12.014
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10
A practical workflow for capillary microsampling in nonclinical studies
Autor: Raja Mangipudy, Ting Su, Linna Wang, Qin C Ji, Kristina D. Chadwick, Bonnie Wang, Renuka Pillutla
Publikováno v: Bioanalysis. 11:175-184
Aim: The result of investigation on the procedure of sample handling and bioanalysis of small volume of plasma sample for nonclinical studies stored in 0.5-ml micronic tubes was reported. Results/methodology: Sample integrity of the small volume (25
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e79fcad10850d3f247bf2327e7dd664
https://doi.org/10.4155/bio-2018-0224
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