Discovery of potential scaffolds for glutaminyl cyclase inhibitors: Virtual screening, synthesis, and evaluation

Autor: Zhou, Qingqing, Cai, Jiaxin, Qin, Feixia, Liu, Jiao, Li, Chenyang, Xiong, Wei, Wang, Yinan, Xu, Chenshu, Wu, Haiqiang

Publikováno v: In Bioorganic & Medicinal Chemistry 1 January 2024 97

Design, synthesis, and evaluation of 4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidine derivatives as potential glutaminyl cyclase isoenzyme inhibitors for the treatment of cancer.

Autor: Zhou Q; School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, 518055, China., Wu Z; School of Pharmacy, Shenzhen University Medical School, Shenzhen, 518055, China., Qin F; School of Pharmacy, Shenzhen University Medical School, Shenzhen, 518055, China., He P; School of Pharmacy, Shenzhen University Medical School, Shenzhen, 518055, China., Wang Z; School of Basic Medicine, Shenzhen University Medical School, Shenzhen, 518055, China., Zhu F; School of Pharmacy, Shenzhen University Medical School, Shenzhen, 518055, China., Gao Y; School of Physical Education, Shenzhen University, Shenzhen, 518060, China., Xiong W; School of Pharmacy, Shenzhen University Medical School, Shenzhen, 518055, China., Li C; School of Pharmacy, Shenzhen University Medical School, Shenzhen, 518055, China., Wu H; School of Pharmacy, Shenzhen University Medical School, Shenzhen, 518055, China. Electronic address: wuhq@szu.edu.cn.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Nov 01; Vol. 281, pp. 117019. Date of Electronic Publication: 2024 Nov 01.