Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Qilian Ma"'
Autor:
Shiqiang Xu, Qilian Ma, Junwen Shen, Ningning Li, Shan Sun, Nana Wang, Yang Chen, Chunsheng Dong, Kin Yip Tam, Jochen H.M. Prehn, Hongfeng Wang, Zheng Ying
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 5, Pp 2026-2038 (2024)
Growing evidences indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two neurodegenerative disorders. The GGGGCC·GGCCCC repeat RNA expansion in chr
Externí odkaz:
https://doaj.org/article/dbd1fbe959004134a85764e04d7c0c51
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Regional bias of N 6-methyladenosine (m6A) mRNA modification avoiding splice site region, calls for an open hypothesis whether exon-intron boundary could affect m6A deposition. By deep learning modeling, we find that exon-intron boundary rep
Externí odkaz:
https://doaj.org/article/3cc15039d62941a39d17b748d857dbe3
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
PINK1 (PTEN induced kinase 1) and PRKN-mediated mitophagy is an important mitochondrial quality control pathway which selectively degrades damaged mitochondria and is tightly associated with neurodegenerative diseases, including Parkinson disease and
Externí odkaz:
https://doaj.org/article/eaa32c2b227f44b3b48853e7abf3ed15
Autor:
Ningning Li, Lingling Rao, Xueqing Zhao, Junwen Shen, Dan Su, Guoqiang Ma, Shan Sun, Qilian Ma, Li Zhang, Chunsheng Dong, Kin Yip Tam, Jochen H. M. Prehn, Hongfeng Wang, Zheng Ying
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Autophagy is a critical protein and organelle quality control system, which regulates cellular homeostasis and survival. Growing pieces of evidence suggest that autophagic dysfunction is strongly associated with many human diseases, including neurolo
Externí odkaz:
https://doaj.org/article/a249e2d9062a453b85a7be08c235801a
Gefitinib facilitates PINK1/Parkin-mediated mitophagy by enhancing mitochondrial recruitment of OPTN
Autor:
Ningning Li, Shan Sun, Guoqiang Ma, Hongyu Hou, Qilian Ma, Li Zhang, Zengli Zhang, Hongfeng Wang, Zheng Ying
Publikováno v:
Fundamental Research, Vol 2, Iss 5, Pp 807-816 (2022)
Gefitinib, a well-known epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor for the targeted therapy of lung cancer, induces autophagy in association with drug resistance. However, it remains unclear whether gefitinib treatment can affe
Externí odkaz:
https://doaj.org/article/2fafca36576142b18274ba4e6e1dad1f
Both pre-mRNA splicing andN6-methyladenosine (m6A) mRNA modification occur during transcription, enabling the potential crosstalk regulation between these two fundamental processes. The regional m6A location bias of avoiding splice site region, calls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd396804c47b1261afdfd243442c8b0c
https://doi.org/10.1101/2022.12.26.521933
https://doi.org/10.1101/2022.12.26.521933
Autor:
Shan Sun, Hongyu Hou, Guoqiang Ma, Qilian Ma, Ningning Li, Li Zhang, Chunsheng Dong, Mian Cao, Kin Yip Tam, Zheng Ying, Hongfeng Wang
Publikováno v:
Journal of Biological Chemistry. 298:102704
The autophagic clearance of mitochondria has been defined as mitophagy, which is triggered by mitochondrial damage and serves as a major pathway for mitochondrial homeostasis and cellular quality control. PINK1 and Parkin-mediated mitophagy is the mo
Autor:
Zeng-li Zhang, Li Yao, Li Zhang, Minhua Shi, Qiu-shi Li, Zheng Ying, Yang Chen, Qilian Ma, Nana Wang, Hongfeng Wang
Publikováno v:
Acta Pharmacologica Sinica
PARK2, which encodes Parkin, is a disease-causing gene for both neurodegenerative disorders and cancer. Parkin can function as a neuroprotector that plays a crucial role in the regulation of mitophagy, and germline mutations in PARK2 are associated w
Autor:
Zheng Ying, Hongfeng Wang, Li Zhang, Nana Wang, Yunhao Yu, Panpan Peng, Yang Chen, Shiqiang Xu, Qilian Ma
Publikováno v:
Neurotoxicity research. 36(1)
Autophagy is an important cellular protein control process, which plays a key role in the regulation of cell homeostasis and pathogenesis of many human diseases including neurodegenerative diseases. Reduced autophagic activity and abnormal protein ag