Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Qili Chu"'
Autor:
David B. Rozema, So C. Wong, Vladimir S. Trubetskoy, Almeida Lauren J, Jonathan D. Benson, Julia Hegge, Darren H. Wakefield, Holly Hamilton, Jeffrey C. Carlson, Jon A. Wolff, Eric A. Kitas, David L. Lewis, Qili Chu, Jason Klein, Anthony Nicholas, Collin M. Hagen, Andrei V. Blokhin
Publikováno v:
Journal of Controlled Release. 209:57-66
The safe and efficacious delivery of membrane impermeable therapeutics requires cytoplasmic access without the toxicity of nonspecific cytoplasmic membrane lysis. We have developed a mechanism for control of cytoplasmic release which utilizes endogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06bffbd8f8ab16c71a0a150c958e0822
Autor:
Gary Christensen, Aaron Andersen, Collin M. Hagen, Holly Hamilton, Julia Hegge, Zhen Li, Qili Chu, Tracie Milarch, Tao Pei, Christine Chapman, Steven B. Kanner, Crystal Klas, Stacey Melquist, Megan Walters, Casi Schienebeck, Zach Trilling, Jeff Casper
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 37
Introduction: Current anticoagulants effectively prevent thromboembolic (TBE) events, but unmet medical need remains due to elevated risk of major bleeding events, particularly where Factor Xa inhibitors are contraindicated. Factor XII (F12) zymogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38ee2f58e185c4647f7bce38ef9cbf7d
https://doi.org/10.1161/atvb.37.suppl_1.36
https://doi.org/10.1161/atvb.37.suppl_1.36
Autor:
R. Zhu, M. Seefeld, Qili Chu, H. Sternard, Holly Hamilton, Christine I. Wooddell, Z. Li, T. Schluep, Bruce D. Given, J. Schumacher
Publikováno v:
Journal of Hepatology. 68:S18-S19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eb8ab15975523600e593850abe28a6a
https://doi.org/10.1016/s0168-8278(18)30255-1
https://doi.org/10.1016/s0168-8278(18)30255-1
Autor:
So C. Wong, Meredith Hinkes, Julia Hegge, Jeremy Briggs, Peter J. Havel, Holly Hamilton, Zhen Li, Qili Chu, James R. Graham, Aaron Andersen, Tao Pei, Gary Christensen, Rui Zhu, Bruce D. Given, Mark Seefeld, Lucas Trilling, James A. Hamilton, Casi Schienebeck, Stephan Bertin
Publikováno v:
Journal of Clinical Lipidology. 13:e15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9da0e1f68b34a05b332b97afa6c5f6a9
https://doi.org/10.1016/j.jacl.2019.04.033
https://doi.org/10.1016/j.jacl.2019.04.033
Autor:
Steven B. Kanner, Keith Blomenkamp, Jeffrey Teckman, Christine I. Wooddell, D. Christianson, Holly Hamilton, Ryan M. Peterson, Qili Chu, Vladimir M. Subbotin
Publikováno v:
Journal of Hepatology. 70:e592
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::794fa86e9e1e7006fc2d6d3831da6c56
https://doi.org/10.1016/s0618-8278(19)31183-1
https://doi.org/10.1016/s0618-8278(19)31183-1
Autor:
Darren H. Wakefield, Kerstin Jahn-Hofmann, Julia Hegge, Claudia E. Oropeza, Hans-Peter Vornlocher, Markus Hossbach, Qili Chu, David B. Rozema, Ingo Roehl, Alan McLachlan, Holly Hamilton, Philipp Hadwiger, Christine I. Wooddell, Matthias John, Jason Klein, Jochen Deckert, David L. Lewis
Publikováno v:
Molecular Therapy
RNA interference (RNAi)-based therapeutics have the potential to treat chronic hepatitis B virus (HBV) infection in a fundamentally different manner than current therapies. Using RNAi, it is possible to knock down expression of viral RNAs including t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd54760eecf60d79cd46602fcf7f0c3a
Autor:
Holly Hamilton, Christine Chapman, David B. Rozema, Jessica Grondolsky, Qili Chu, David L. Lewis, Almeida Lauren J, Julia Hegge, Darren H. Wakefield, Jane Hoover-Plow, Vladimir S. Trubetskoy, Steven Kanner, Stacey Melquist, Aaron Almeida
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36
Background: Meta-analyses of clinical studies have demonstrated that high levels of lipoprotein(a), known as Lp(a), correlate with residual risk of cardiovascular disease (CVD) while Mendelian genetic studies indicate that Lp(a) is an independent cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42ec8d2075d7b636f616bfd63c10a19f
https://doi.org/10.1161/atvb.36.suppl_1.428
https://doi.org/10.1161/atvb.36.suppl_1.428
Autor:
Christine I. Wooddell, Holly Hamilton, J. Griffin, Qili Chu, D. Christianson, H. Chen, Keith Blomenkamp, Jeffery H. Teckman, J. Hegge, R. Zhu, Bruce D. Given, Z. Li
Publikováno v:
Journal of Hepatology. 68:S82
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::447e9d7c8b369de6bb12034cd35714c8
https://doi.org/10.1016/s0168-8278(18)30383-0
https://doi.org/10.1016/s0168-8278(18)30383-0
Publikováno v:
Molecular Immunology. 45:1501-1513
Natural IgM antibodies (Abs) play an important role in clearing pathogens, enhancing immune responses, and preventing autoimmunity. However, the molecular mechanisms that mediate the functions of natural IgM Abs are understood only to a limited degre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07fef2d753a8a94bb1ee01b8c03449ba
https://doi.org/10.1016/j.molimm.2007.07.043
https://doi.org/10.1016/j.molimm.2007.07.043
Autor:
Tom W. Reppen, Andrei V. Blokhin, Darren H. Wakefield, Jon A. Wolff, David B. Rozema, Qili Chu, James E. Hagstrom, Paula L. Roesch, David L. Lewis, Stephanie Bertin, Jason Klein, So C. Wong
Publikováno v:
Proceedings of the National Academy of Sciences. 104:12982-12987
Achieving efficient in vivo delivery of siRNA to the appropriate target cell would be a major advance in the use of RNAi in gene function studies and as a therapeutic modality. Hepatocytes, the key parenchymal cells of the liver, are a particularly a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bdceee717e6a07f092bfc5444cd86e4
https://doi.org/10.1073/pnas.0703778104
https://doi.org/10.1073/pnas.0703778104