Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Qijun Qian"'
Autor:
Yan Zhang, Zhicai Lin, Faliang Zhang, Xiuxiu Chen, Yaping Yang, Xin Fu, Zhong Li, Yan Sun, Qijun Qian
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
CD19-directed chimeric antigen receptor (CAR) T cell therapy has been shown to achieve a considerably durable response in patients with refractory or relapsed B cell non-Hodgkin lymphomas, as seen from the results of Zuma-1, Zuma-5, and other clinica
Externí odkaz:
https://doaj.org/article/d384bc396ee947d59a7bd873bacca1ed
Autor:
Lu Wen, Yu Huang, Ling Peng, Kaiping Zhao, Yan Sun, Zhicai Lin, Yuanyuan Chen, Zhong Li, Qijun Qian, Fan Tong, Ruiguang Zhang, Xiaorong Dong
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
“On-target off-tumor” toxicity is a major challenge to the use of chimeric antigen receptor (CAR)-engineered T cells in the treatment of solid malignancies, because of the expression of target antigens in normal tissues. Mesothelin overexpression
Externí odkaz:
https://doaj.org/article/e6c679aae52c4222b1f5d0f2912f045e
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-10 (2021)
Abstract Background Although chimeric antigen receptor (CAR)-T cell therapy has been remarkably successful for haematological malignancies, its efficacy against solid tumors is limited. The combination of CAR-T cell therapy with immune checkpoint inh
Externí odkaz:
https://doaj.org/article/3a673071c0194fdaadec888d4f482257
Autor:
Yuan Fang, Yajun Zhang, Chuanxin Guo, Chumeng Chen, Haixia Gao, Xiumei Zhou, Tao Liu, Qijun Qian
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 14-23 (2020)
T cells modified to co-express cytokine or other factors with chimeric antigen receptor (CAR) can induce substantial and persistent increases in antitumor capacity in vivo. However, the uncontrolled expression of cytokines or factors can lead to the
Externí odkaz:
https://doaj.org/article/da89967370a6493ea420c4fa943fba85
Autor:
Zhicai Lin, Xiangzhen Liu, Tao Liu, Haixia Gao, Sitong Wang, Xingli Zhu, Lijie Rong, Jingbo Cheng, Zhigang Cai, Fu Xu, Xue Tan, Linjie Lv, Zhong Li, Yan Sun, Qijun Qian
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Nonviral transposon piggyBac (PB) and lentiviral (LV) vectors have been used to deliver chimeric antigen receptor (CAR) to T cells. To understand the differences in the effects of PB and LV on CAR T-cell functions, a CAR targeting CD19 was cloned int
Externí odkaz:
https://doaj.org/article/48dd910158b242da9b360cf4e7840b7c
Autor:
Wenzhu Jia, Emmanuel Asare, Tao Liu, Pingjing Zhang, Yali Wang, Saisai Wang, Dan Shen, Csaba Miskey, Bo Gao, Zoltán Ivics, Qijun Qian, Chengyi Song
Publikováno v:
Genes, Vol 13, Iss 12, p 2239 (2022)
Both ZeBrafish (ZB), a recently identified DNA transposon in the zebrafish genome, and SB, a reconstructed transposon originally discovered in several fish species, are known to exhibit high transposition activity in vertebrate cells. Although a simi
Externí odkaz:
https://doaj.org/article/d40f80076a4c4c3b8cbb4de29b88d782
Autor:
Chenggong Li, Yan Sun, Jing Wang, Lu Tang, Huiwen Jiang, Tao Guo, Lin Liu, Yaohui Wu, Lisha Ai, Linghui Xia, Jianjun Wu, Zhicai Lin, Qijun Qian, Yu Hu, Heng Mei
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
MYC/BCL2/BCL6 triple-hit lymphoma (THL) is an uncommon subset of high-grade B-cell lymphoma with aggressive clinical behavior and poor prognosis. TP53 mutation is an independently poor progonistic indicator in patients with THL, hence novel therapeut
Externí odkaz:
https://doaj.org/article/2ce88c585f35476b847f7cadce095083
Autor:
Hui Wang, Zhong Li, Yan Sun, Wei Mao, Min Yuan, Juemin Fang, Qing Xu, Na Ding, Xinling Guo, Zhiwei Zhang, Bailu Xie, Zhicai Lin, Fei Qin, Wenqi Chu, Huanlong Qin, Qijun Qian
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Case presentation Here we report a case of refractory EOC in a patient who had relapsed after multiline chemotherapy. The patient received autologous T cells that contained sequences encoding single-chain variable fragments specific for MSLN and full
Externí odkaz:
https://doaj.org/article/ed91fbbb646c4b91bb03e83a89baa001
Publikováno v:
Journal of Immunology Research, Vol 2020 (2020)
The success of peptide-based dendritic cell (DC) cancer vaccines mainly depends on the utilized peptides and selection of an appropriate adjuvant. Herein, we aimed to evoke a broad immune response against multiple epitopes concurrently in the presenc
Externí odkaz:
https://doaj.org/article/d111729b936f4162a686857db9316cbb
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3064 (2020)
As non-viral transgenic vectors, the piggyBac transposon system represents an attractive tool for gene delivery to achieve a long-term gene expression in immunotherapy applications due to its large cargo capacity, its lack of a trace of transposon an
Externí odkaz:
https://doaj.org/article/b51460e1cd624af8bb3c2cbbd9cbfeeb