Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Qihui Kong"'
Autor:
Zhengchao Xie, Lin Weng, Jingjing He, Xianzhong Feng, Xiaogang Xu, Yinxing Ma, Panpan Bai, Qihui Kong
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
Genomic selection (GS) can accomplish breeding faster than phenotypic selection. Improving prediction accuracy is the key to promoting GS. To improve the GS prediction accuracy and stability, we introduce parallel convolution to deep learning for GS
Externí odkaz:
https://doaj.org/article/413e61a69eae48e193d95de38b9a4d53
Publikováno v:
PeerJ, Vol 11, p e16601 (2023)
This study aimed to investigate the interactions between icotinib/apatinib and oxycodone in rats and to unveil the underlying mechanism. An ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) method was developed and valid
Externí odkaz:
https://doaj.org/article/0cb7cba3db2541049f3ef965d5f99d45
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
The aim of this study is to investigate the effects of CYP3A4 genetic polymorphisms on the metabolism of cyclosporine (CsA) in vitro and identify drugs that interact with CsA. An enzymatic incubation system was developed to evaluate the kinetic param
Externí odkaz:
https://doaj.org/article/d21f847fc4ad48f485377679bf31182c
Autor:
Zhize Ye, Bingbing Chen, Nanyong Gao, Qihui Kong, Xiaoqin Hu, Zhongqiu Lu, Jianchang Qian, Guoxin Hu, Jianping Cai, Bin Wu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
This study aimed 1) to investigate the influence of CYP2D6 variants on the catalyzing of fluvoxamine, and 2) to study the interaction between fluvoxamine and apatinib. An enzymatic reaction system was setup and the kinetic profile of CYP2D6 in metabo
Externí odkaz:
https://doaj.org/article/f2d5609d984b470db4d45a747477102c
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The aim of this study was to 1) investigate the effects of 27 CYP3A4 variants on the metabolism of osimertinib and 2) study the interactions between osimertinib and others as well as the underlying mechanism. A recombinant human CYP3A4 enzymatic incu
Externí odkaz:
https://doaj.org/article/04e3715f44b74255bdada248224e038f
Publikováno v:
Plants, Vol 12, Iss 5, p 1017 (2023)
The new gene-editing technology CRISPR/Cas system has been widely used for genome engineering in various organisms. Since the CRISPR/Cas gene-editing system has a certain possibility of low efficiency and the whole plant transformation of soybean is
Externí odkaz:
https://doaj.org/article/74efab8decf646ceaff2c8ed18a61a77
Publikováno v:
Frontiers in Plant Science, Vol 10 (2019)
Ferric reductase oxidase (FRO), the enzyme that reduced ferric iron [Fe (III)] into ferrous iron [Fe (II)], is known to play important roles in Fe absorption and homeostasis in plants that utilize a strategy I mechanism to obtain iron. Rice can use b
Externí odkaz:
https://doaj.org/article/f4eef284ec6440229fec23e35eef4a89
Autor:
Mingming Han, Xiaodan Zhang, Zhize Ye, Jing Wang, Qihui Kong, Xiaoqin Hu, Jianchang Qian, Jianping Cai, Guoxin Hu
Publikováno v:
Chemical research in toxicology. 35(2)
We aim to study the effects of CYP2D6 variants and drug-drug interaction on the metabolism of dacomitinib. CYP2D6 variants were incubated with 25-1000 μM dacomitinib for 40 min at 37 °C, and the reaction was terminated by cooling to -80 °C immedia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055de62a022c401f677c0fb1537aa0e6
https://pubmed.ncbi.nlm.nih.gov/34936353
https://pubmed.ncbi.nlm.nih.gov/34936353
Publikováno v:
Chemico-Biological Interactions. 364:110044
Cancer patients experience pain during medical treatment. Therefore, anticancer drugs and painkillers are often prescribed together. This study aims to determine the interaction between anlotinib and oxycodone and reveal the underlying mechanism.UPLC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08dcde908e54fc65ee1cc23271ebf899
https://doi.org/10.1016/j.cbi.2022.110044
https://doi.org/10.1016/j.cbi.2022.110044
Publikováno v:
Journal of Integrative Plant Biology. 60:608-622
Iron is an indispensable micronutrient for plant growth and development. Limited bioavailability of Fe in the soil leads to iron deficiency chlorosis in plants and yield loss. In this study, two soybean basic helix-loop-helix transcription factors, G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ef4378c04b522dcc892dfb0701a4ed2
https://doi.org/10.1111/jipb.12651
https://doi.org/10.1111/jipb.12651