Zobrazeno 1 - 10
of 446
pro vyhledávání: '"Qihua Tan"'
Autor:
Asmus Cosmos Skovgaard, Afsaneh Mohammadnejad, Hans Christian Beck, Qihua Tan, Mette Soerensen
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background Cardiovascular diseases (CVDs) are major causes of mortality and morbidity worldwide; yet the understanding of their molecular basis is incomplete. Multi-omics studies have significant potential to uncover these mechanisms, but su
Externí odkaz:
https://doaj.org/article/41681d54596c4218b38a874c3f35ba32
Autor:
Pui Pik Law, Liudmila A. Mikheeva, Francisco Rodriguez-Algarra, Fredrika Asenius, Maria Gregori, Robert A. E. Seaborne, Selin Yildizoglu, James R. C. Miller, Hemanth Tummala, Robin Mesnage, Michael N. Antoniou, Weilong Li, Qihua Tan, Sara L. Hillman, Vardhman K. Rakyan, David J. Williams, Michelle L. Holland
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Body mass results from a complex interplay between genetics and environment. Previous studies of the genetic contribution to body mass have excluded repetitive regions due to the technical limitations of platforms used for population scale s
Externí odkaz:
https://doaj.org/article/80eab87c54514fd3a8296ed1fbbcc98c
Autor:
Ines Block, Mark Burton, Kristina P. Sørensen, Martin J. Larsen, Thi T. N. Do, Martin Bak, Søren Cold, Mads Thomassen, Qihua Tan, Torben A. Kruse
Publikováno v:
Cancer Medicine, Vol 13, Iss 9, Pp n/a-n/a (2024)
Abstract Background Current clinical markers overestimate the recurrence risk in many lymph node negative (LNN) breast cancer (BC) patients such that a majority of these low‐risk patients unnecessarily receive systemic treatments. We tested if diff
Externí odkaz:
https://doaj.org/article/f87c4fa2f826470a8dde22579f310ce2
Autor:
Weijing Wang, Wenqin Yao, Qihua Tan, Shuxia Li, Haiping Duan, Xiaocao Tian, Chunsheng Xu, Dongfeng Zhang
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Background Elevated fasting plasma glucose (FPG) levels can increase morbidity and mortality even when it is below the diagnostic threshold of type 2 diabetes mellitus (T2DM). We conducted a genome-wide DNA methylation analysis to detect DNA
Externí odkaz:
https://doaj.org/article/1242f0aeb1d149b2b2998635a3c0f40a
Autor:
Yi Zeng, Huashuai Chen, Xiaomin Liu, Zijun Song, Yao Yao, Xiaoyan Lei, Xiaozhen Lv, Lingguo Cheng, Zhihua Chen, Chen Bai, Zhaoxue Yin, Yuebin Lv, Jiehua Lu, Jianxin Li, Kenneth C. Land, Anatoliy Yashin, Angela M. O'Rand, Liang Sun, Ze Yang, Wei Tao, Jun Gu, William Gottschalk, Qihua Tan, Kaare Christensen, Therese Hesketh, Xiao-Li Tian, Huanming Yang, Viviana Egidi, Graziella Caselli, Jean-Marie Robine, Huali Wang, Xiaoming Shi, James W. Vaupel, Michael W. Lutz, Chao Nie, Junxia Min
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23691- (2024)
It is long observed that females tend to live longer than males in nearly every country. However, the underlying mechanism remains elusive. In this study, we discovered that genetic associations with longevity are on average stronger in females than
Externí odkaz:
https://doaj.org/article/4e57bb6e16fe4cc6aea7dbad954c40b9
Autor:
Qihua Tan, Anaïs Marie Julie Møller, Chuan Qiu, Jonna Skov Madsen, Hui Shen, Troels Bechmann, Jean-Marie Delaisse, Bjarne Winther Kristensen, Hong-Wen Deng, David Karasik, Kent Søe
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background Clinical trials have shown zoledronic acid as a potent bisphosphonate in preventing bone loss, but with varying potency between patients. Human osteoclasts ex vivo reportedly displayed a variable sensitivity to zoledronic acid > 2
Externí odkaz:
https://doaj.org/article/9718cb5c044c48b18465cf4ae6ccc452
Autor:
Weijing Wang, Jie Yao, Weilong Li, Yili Wu, Haiping Duan, Chunsheng Xu, Xiaocao Tian, Shuxia Li, Qihua Tan, Dongfeng Zhang
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background Hypertension is a crucial risk factor for developing cardiovascular disease and reducing life expectancy. We aimed to detect DNA methylation (DNAm) variants potentially related to systolic blood pressure (SBP) and diastolic blood
Externí odkaz:
https://doaj.org/article/3f38a2774ad14d45bd2f8af620072e6a
Autor:
Karri Silventoinen, Maarit Piirtola, Aline Jelenkovic, Reijo Sund, Adam D. Tarnoki, David L. Tarnoki, Emanuela Medda, Lorenza Nisticò, Virgilia Toccaceli, Chika Honda, Fujio Inui, Rie Tomizawa, Mikio Watanabe, Norio Sakai, Margaret Gatz, David A. Butler, Jooyeon Lee, Soo Ji Lee, Joohon Sung, Carol E. Franz, William S. Kremen, Michael J. Lyons, Catherine A. Derom, Robert F. Vlietinck, Ruth J. F. Loos, Per Tynelius, Finn Rasmussen, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Ingunn Brandt, Thomas S. Nilsen, Jennifer R. Harris, Jessica Tyler, John L. Hopper, Patrik K. E. Magnusson, Nancy L. Pedersen, Anna K. Dahl Aslan, Juan R. Ordoñana, Juan F. Sánchez-Romera, Lucia Colodro-Conde, Esther Rebato, Dongfeng Zhang, Zengchang Pang, Qihua Tan, Judy L. Silberg, Hermine H. Maes, Dorret I. Boomsma, Thorkild I. A. Sørensen, Tellervo Korhonen, Jaakko Kaprio
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract We tested the causality between education and smoking using the natural experiment of discordant twin pairs allowing to optimally control for background genetic and childhood social factors. Data from 18 cohorts including 10,527 monozygotic
Externí odkaz:
https://doaj.org/article/a04289e4c6684fb58b460af114fe9ff4
Autor:
Weijing Wang, Weilong Li, Yili Wu, Xiaocao Tian, Haiping Duan, Shuxia Li, Qihua Tan, Dongfeng Zhang
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Depression is currently the leading cause of disability around the world. We conducted an epigenome-wide association study (EWAS) in a sample of 58 depression score-discordant monozygotic twin pairs, aiming to detect specific epigenetic vari
Externí odkaz:
https://doaj.org/article/9751ad3ad80a4a9cb91418ff30c8be5b
Autor:
Jonas Mengel-From, Rune Lindahl-Jacobsen, Marianne Nygaard, Mette Soerensen, Karen Helene Ørstavik, Jens Michael Hertz, Karen Andersen-Ranberg, Qihua Tan, Kaare Christensen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Mosaicism in blood varies with age, and cross-sectional studies indicate that for women, skewness of X-chromosomal mosaicism increases with age. This pattern could, however, also be due to less X-inactivation in more recent birth cohorts. Sk
Externí odkaz:
https://doaj.org/article/ab07ac69036a4bceb82d8564985ca5bb