Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Qihan Wu"'
Autor:
Wanhong He, Haijun Zhu, Sufen Zhang, Guang Shu, Han Lei, Gang Yin, Xiaohua Ni, Maonan Wang, Qihan Wu
Publikováno v:
Clinical and Experimental Obstetrics & Gynecology, Vol 51, Iss 5, p 109 (2024)
Background: Ovarian cancer has a poor prognosis, and DNA damage-response (DDR) genes are associated with both its occurrence and prognosis. However, previous studies have mostly focused on genetic mutations, with no clear conclusions on epigenetic fa
Externí odkaz:
https://doaj.org/article/2fe8ade770c9429882de5dfb8f3a9a28
Autor:
Yi Zhang, Hongyan Qi, Long Wang, Chunyan Hu, Aibo Gao, Qihan Wu, Qiaoling Wang, Huibin Lin, Banru Chen, Xingyu Wang, Shuangyuan Wang, Hong Lin, Weiqing Wang, Yufang Bi, Jiqiu Wang, Jieli Lu, Ruixin Liu
Publikováno v:
Journal of Diabetes, Vol 15, Iss 2, Pp 165-180 (2023)
Abstract Background Bile acids (BAs) are closely related to nutrient supply and modified by gut microbiota. Gut microbiota perturbations shape BA composition, which further affects host metabolism. Methods We investigated BA profiles in plasma, feces
Externí odkaz:
https://doaj.org/article/f89c5fb1e5d144dda3890f794afecf37
Autor:
Wanhong He, Haijun Zhu, Sufen Zhang, Guang Shu, Han Lei, Maonan Wang, Gang Yin, Xiaohua Ni, Qihan Wu
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTDrug resistance is the primary contributor to the high mortality rate of ovarian cancer (OC). The loss of BRCA1/2 function is linked to drug sensitivity in OC cells. The aim of this study is to enhance the drug sensitivity of OC cells by indu
Externí odkaz:
https://doaj.org/article/b7ff626e9d9a4df49e95f8f75fa20415
Publikováno v:
Clinical and Experimental Obstetrics & Gynecology, Vol 50, Iss 10, p 204 (2023)
Background: Uterine corpus endometrial carcinoma (UCEC) is a prevalent gynaecologic malignancy. It has been demonstrated that the immune cell infiltration (ICI) pattern plays a critical role in the tumour progression of UCEC. Methods: To further inve
Externí odkaz:
https://doaj.org/article/96971d97b25441c280c5534c47c9b40f
Autor:
Xiaoya Duan, Yuanyong Huang, Xiaoxing Chen, Wencai Wang, Jiwei Chen, Jialun Li, Wei Yang, Jiwen Li, Qihan Wu, Jiemin Wong
Publikováno v:
Oncogenesis, Vol 10, Iss 5, Pp 1-15 (2021)
Abstract Global DNA hypomethylation is a most common epigenetic alteration in human neoplasia. However, accumulative evidence shows that global DNA hypomethylation impacts tumorigenesis in a tissue-specific manner, promoting tumorigenesis in some but
Externí odkaz:
https://doaj.org/article/89439fd7f9174fd8a6d16151738f6991
Autor:
Zhiyin Zhang, Qihan Wu, Yang He, Peng Lu, Danjie Li, Minglan Yang, Weiqiong Gu, Ruixin Liu, Jie Hong, Jiqiu Wang
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
ObjectiveThe Iroquois homeobox 3 (IRX3) gene was recently reported to be a functional downstream target of a common polymorphism in the FTO gene, which encodes an obesity-associated protein; however, the role of IRX3 in energy expenditure remains unc
Externí odkaz:
https://doaj.org/article/a8c0b2fa6b9947e79631fb50ea9c9368
Publikováno v:
Virology Journal, Vol 15, Iss 1, Pp 1-9 (2018)
Abstract Background Viral infection activates innate immune pathways and interferons (IFNs) play a pivotal role in the outcome of a viral infection. Ubiquitin modifications of host and viral proteins significantly influence the progress of virus infe
Externí odkaz:
https://doaj.org/article/40509e7b91f24447ae775960f1a83211
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 3, p e0007202 (2019)
Dengue virus (DENV) is the most important vector-borne virus globally. The safe and effective vaccines are still under development and there are no antiviral drugs for DENV induced diseases. In this study, we obtained five DENV1 isolates (DENV1 A to
Externí odkaz:
https://doaj.org/article/36495a146f424b9183138b7145511f73
Autor:
Qian Zhao, Jiqin Zhang, Ruoyu Chen, Lina Wang, Bo Li, Hao Cheng, Xiaoya Duan, Haijun Zhu, Wei Wei, Jiwen Li, Qihan Wu, Jing-Dong J. Han, Wenqiang Yu, Shaorong Gao, Guohong Li, Jiemin Wong
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
There is crosstalk between the maintenance of DNA methylation and histone methylation. Here, the authors create an Uhrf1 knockin mouse model that abolishes the H3K9me2/3-binding activity of Uhrf1, and show that DNA maintenance methylation in mammals
Externí odkaz:
https://doaj.org/article/eaa46b60799b4bfabd64eeb76e38f5dd
Autor:
Kezhen Wang, Chunling Zou, Xiujuan Wang, Chenxiao Huang, Tingting Feng, Wen Pan, Qihan Wu, Penghua Wang, Jianfeng Dai
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007287 (2018)
In order to eliminate viral infections, hundreds of interferon-stimulated genes (ISGs) are induced via type I interferons (IFNs). However, the functions and mechanisms of most ISGs are largely unclear. A tripartite motif (TRIM) protein encoding gene
Externí odkaz:
https://doaj.org/article/bc988182804c4c48b2cea1b77a5bc917