Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Qifeng Bai"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2839-2847 (2022)
Repositioning or repurposing drugs account for a substantial part of entering approval pipeline drugs, which indicates that drug repositioning has huge market potential and value. Computational technologies such as machine learning methods have accel
Externí odkaz:
https://doaj.org/article/a0ff253cb2fc4394aaef611c067ae487
Publikováno v:
Mathematics, Vol 11, Iss 6, p 1279 (2023)
Deep learning is a sub-discipline of artificial intelligence that uses artificial neural networks, a machine learning technique, to extract patterns and make predictions from large datasets. In recent years, it has achieved rapid development and is w
Externí odkaz:
https://doaj.org/article/29040247bb5a406c912c5fa2ee4729a7
Autor:
Qifeng Bai, Jian Ma, Shuo Liu, Tingyang Xu, Antonio Jesús Banegas-Luna, Horacio Pérez-Sánchez, Yanan Tian, Junzhou Huang, Huanxiang Liu, Xiaojun Yao
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3573-3579 (2021)
Artificial intelligence can train the related known drug data into deep learning models for drug design, while classical algorithms can design drugs through established and predefined procedures. Both deep learning and classical algorithms have their
Externí odkaz:
https://doaj.org/article/82a60e26d61540a59e317a7abf1148ed
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3978-3989 (2021)
Activation of human free fatty acid receptor 1 (FFAR1, also called hGPR40) enhances insulin secretion in a glucose-dependent manner. Hence, the development of selective agonist targeting hGPR40 has been proposed as a therapeutic strategy of type 2 di
Externí odkaz:
https://doaj.org/article/ef14d48b7d164e7396149f781c96a929
Autor:
Qifeng Bai, Shuoyan Tan, Horacio Pérez-Sánchez, Haixia Feng, Liya Feng, HuanXiang Liu, Xiaojun Yao
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
The inactive conformations of glucagon receptor (GCGR) are widely reported by crystal structures that support the precision structure for drug discovery of type 2 diabetes. The previous study shows that the intracellular part is open in the glucagon-
Externí odkaz:
https://doaj.org/article/d487b97e6abc472b93fc983690a87c22
Autor:
Hong Yuan, Pinghua Li, Xueqing Ma, Zengjun Lu, Pu Sun, Xingwen Bai, Jing Zhang, Huifang Bao, Yimei Cao, Dong Li, Yuanfang Fu, Yingli Chen, Qifeng Bai, Jie Zhang, Zaixin Liu
Publikováno v:
Virology Journal, Vol 14, Iss 1, Pp 1-10 (2017)
Abstract ᅟ This review summarized the molecular determinants of the acid stability of FMDV in order to explore the uncoating mechanism of FMDV and improve the acid stability of vaccines. Background The foot-and-mouth disease virus (FMDV) capsid is
Externí odkaz:
https://doaj.org/article/4e9da92eab4a49fa9197c771c946b9cc
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Recently, small-molecule compounds have been reported to block the PD-1/PD-L1 interaction by inducing the dimerization of PD-L1. All these inhibitors had a common scaffold and interacted with the cavity formed by two PD-L1 monomers. This special inte
Externí odkaz:
https://doaj.org/article/df83e8bd99934ec6b8846024f0291b6f
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
The smoothened receptor (Smo) plays a key role in Hedgehog (Hh) signaling pathway and it has been regarded as an efficacious therapeutic target for basal cell carcinoma (BCC) and medulloblastoma (MB). Nevertheless, the resistance mutation and active
Externí odkaz:
https://doaj.org/article/7ebdf902a26546d6bb0434cbe3b7cd2f
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145219 (2015)
As a promising target for the treatment of lung cancer, the MutT Homolog 1 (MTH1) protein can be inhibited by crizotinib. A recent work shows that the inhibitory potency of (S)-crizotinib against MTH1 is about 20 times over that of (R)-crizotinib. Bu
Externí odkaz:
https://doaj.org/article/01116b6a0c334b09bb18db25eeecc2b3
Autor:
Dong Qian, Qiong Nan, Yueming Yang, Hui Li, Yuelong Zhou, Jingen Zhu, Qifeng Bai, Pan Zhang, Lizhe An, Yun Xiang
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143174 (2015)
The villin/gelsolin/fragmin superfamily is a major group of Ca2+-dependent actin-binding proteins (ABPs) involved in various cellular processes. Members of this superfamily typically possess three or six tandem gelsolin-like (G) domains, and each dom
Externí odkaz:
https://doaj.org/article/8a11c200b7ff4a709e42833259f6dd0b