Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Qifang Kuang"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 4, Iss 1, Pp 67-73 (2014)
Cell-penetrating peptides (CPPs) have been widely used to enhance the membrane translocation of various carriers for many years, but the non-specificity of CPPs seriously limits their utility in vivo. In this study, cholesterol-anchored, reduction-se
Externí odkaz:
https://doaj.org/article/6ee62495c65644d78f8d7193d29b0519
Autor:
Jie Tang, Li Zhang, Zhirong Zhang, Yayuan Liu, Huile Gao, Qifang Kuang, Qianyu Zhang, Han Fu, Rui Ran, Qin He
Tumor targeted drug delivery system with high efficiency of tumor accumulation, cell internalization and endosomal escape was considered ideal for cancer therapy. Herein, a cleavable polyethylene glycol (PEG) and octaarginines (R8) co-modified liposo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af91b60da5e3d87f7c94c158401580f
Autor:
Libao Lu, Kairong Shi, Yantao Chen, Wenfei Chen, Li Zhang, Mingling Dong, Han Fu, Qifang Kuang, Yuting Yang, Qin He, Guanlian Hu
Publikováno v:
Journal of Pharmaceutical Sciences. 104:1160-1173
To combine the advantage of poly(ethylene gylcol) (PEG) for longer circulation and cell-penetrating peptides (CPPs) for efficient cellular uptake, paclitaxel (PTX)-loaded liposomes functionalized with TAT, the most frequently used CPP, and cleavable
Autor:
Kai Huang, Zhirong Zhang, Qifang Kuang, Jie Tang, Huile Gao, Rui Ran, Qin He, Qianyu Zhang, Xiaoxiao Chen, Yayuan Liu
Publikováno v:
International Journal of Pharmaceutics. 477:590-600
RNA interference is an effective method to achieve highly specific gene regulation. However, the commonly used cationic liposomes have poor biocompatibility, which may lead to systematic siRNA delivery of no avail. PEGylation is a good strategy in sh
Autor:
Wei Xiao, Yang Wang, Kairong Shi, Chuan Hu, Qin He, Qifang Kuang, Xingli Cun, Shaobo Ruan, Huile Gao, Guanlian Hu
Publikováno v:
Scientific Reports
In recent years, active targeting strategies by ligand modification have emerged to enhance tumor accumulation of NP, but their clinical application was strictly restricted due to the complex preparation procedures, poor stability and serious toxicit
Autor:
Jie Tang, Qianyu Zhang, Zhirong Zhang, Rui Ran, Huile Gao, Qin He, Qifang Kuang, Han Fu, Yayuan Liu
Publikováno v:
Journal of pharmaceutical sciences. 104(2)
Human chromosome 7 open reading frame 24 has been identified as a tumor-related protein, and later it was shown to be γ-glutamylcyclotransferase (GGCT). This protein is upregulated in various types of cancer and is proved to be associated with cellu
Autor:
Ling Mei, Rui Ran, Huile Gao, Qin He, Jiantao Chen, Zhirong Zhang, Jie Tang, Yayuan Liu, Qianyu Zhang, Qifang Kuang
Publikováno v:
Biomaterials. 35(17)
The treatment of glioma is a great challenge because of the existence of the blood-brain barrier (BBB). In order to reduce toxicity to the normal brain tissue and achieve efficient treatment, it is also important for drugs to specifically accumulate