Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Qielan Wu"'
Autor:
Chenxi Tian, Yu Wang, Miya Su, Yuanyuan Huang, Yuwei Zhang, Jiaxiang Dou, Changfeng Zhao, Yuting Cai, Jun Pan, Shiyu Bai, Qielan Wu, Sanwei Chen, Shuhang Li, Di Xie, Rong Lv, Yusheng Chen, Yucai Wang, Sicheng Fu, Huimin Zhang, Li Bai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Dysfunction of invariant natural killer T (iNKT) cells contributes to immune resistance of tumors. Most mechanistic studies focus on their static functional status before or after activation, not considering motility as an important characte
Externí odkaz:
https://doaj.org/article/b5864dc1d5a64196a7eb134d5695dc95
Autor:
Shiyu Bai, Qielan Wu, Shasha Zhu, Yuwei Zhang, Xuran Chen, Miya Su, Jun Pan, Shuhang Li, Ting Yue, Linfeng Xu, Di Xie, Chenxi Tian, Dan Zhao, Xiang Li, Junjie Hou, Lu Wang, Sicheng Fu, Yanhong Xue, Amin Jiang, Dong Li, Tao Xu, Zhigang Tian, Rongbin Zhou, Huimin Zhang, Li Bai
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Activation of mTORC1 is essential for anti-tumor function of iNKT cells. The mechanisms underlying impaired mTORC1 activation in intratumoral iNKT cells remain unclear. Via generating Vam6+/- mice and using flow cytometry, image approach, and RNA seq
Externí odkaz:
https://doaj.org/article/99ead38d43864f3694aedd6d0c626901
Autor:
Sicheng Fu, Kaixin He, Chenxi Tian, Hua Sun, Chenwen Zhu, Shiyu Bai, Jiwei Liu, Qielan Wu, Di Xie, Ting Yue, Zhuxia Shen, Qingqing Dai, Xiaojun Yu, Shu Zhu, Gang Liu, Rongbin Zhou, Shengzhong Duan, Zhigang Tian, Tao Xu, Hua Wang, Li Bai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Lipid metabolism has been linked to iNKT function largely as it impacts processing and presentation of lipids they recognize. Here the authors show that iNKT-intrinsic lipid biosynthesis is important for their function but is impaired in tumors, and
Externí odkaz:
https://doaj.org/article/c605c340c0c94f1b8a85da028df9b400
Autor:
Lu Wang, Di Xie, Qielan Wu, Huimin Zhang, Chen Jin, Xiang Li, Qi Chen, Shiyu Bai, Xihua Zheng, Li Bai
Publikováno v:
Journal of Leukocyte Biology. 111:1199-1210
Invariant NK T (iNKT) cells are innate-like lymphocytes that can recognize the lipid Ag presented by MHC I like molecule CD1d. Distinct tissue distribution of iNKT cells subsets implies a contribution of these subsets to their related tissue regional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb8bb3a7f9e5ed1ac1f9f711b5260fa
https://doi.org/10.1002/jlb.1a0621-309r
https://doi.org/10.1002/jlb.1a0621-309r
Autor:
Huimin Zhang, Shiyu Bai, Qielan Wu, Shasha Zhu, Yuwei Zhang, Xuran Chen, Jun Pan, Shuhang Li, Ting Yue, Linfeng Xu, Di Xie, Chenxi Tian, Xiang Li, Junjie Hou, Lu Wang, Sicheng Fu, Yanhong Xue, Amin Jiang, Dong Li, Tao Xu, Zhigang Tian, Rongbin Zhou, Li Bai
Activation of mTORC1 is essential for anti-tumor function of iNKT cells. The mechanisms underlying impaired mTORC1 activation in intratumoral iNKT cells remain unclear. Here, we showed that lactic acid from tumor cells increased Vam6 expression in iN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7ebaf6f51c0cbbe8adccbca9de4dca0
https://doi.org/10.21203/rs.3.rs-1990874/v1
https://doi.org/10.21203/rs.3.rs-1990874/v1
Autor:
Li Bai, Hua Wang, Zhigang Tian, Qingqing Dai, Di Xie, Tao Xu, Hua Sun, Jiwei Liu, Kaixin He, Shu Zhu, Shiyu Bai, Gang Liu, Sicheng Fu, Chenxi Tian, Shengzhong Duan, Ting Yue, Xiaojun Yu, Zhuxia Shen, Rongbin Zhou, Qielan Wu, Chenwen Zhu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Dysfunction of invariant natural killer T (iNKT) cells in tumor microenvironment hinders their anti-tumor efficacy, and the underlying mechanisms remain unclear. Here we report that iNKT cells increase lipid biosynthesis after activation, and that is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8df60cd39639a1a12aa6cb8e58ec77
https://doaj.org/article/c605c340c0c94f1b8a85da028df9b400
https://doaj.org/article/c605c340c0c94f1b8a85da028df9b400
Autor:
Xiang, Li, Chen, Jin, Qi, Chen, Xihua, Zheng, Di, Xie, Qielan, Wu, Lu, Wang, Shiyu, Bai, Huimin, Zhang, Li, Bai
Publikováno v:
Journal of leukocyte biologyREFERENCES. 111(6)
Invariant NK T (iNKT) cells are innate-like lymphocytes that can recognize the lipid Ag presented by MHC I like molecule CD1d. Distinct tissue distribution of iNKT cells subsets implies a contribution of these subsets to their related tissue regional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::99834b7b5e300515175be53e8fc42bd1
https://pubmed.ncbi.nlm.nih.gov/34730251
https://pubmed.ncbi.nlm.nih.gov/34730251
Autor:
Qielan Wu, Shiyu Bai, Zhigang Tian, Fengyin Li, Mingzhao Zhu, Huimin Zhang, Yuwei Zhang, Li Bai, Chenxi Tian, Yuanyuan Huang, Jun Pan, Zhe-Xiong Lian
Publikováno v:
Proc Natl Acad Sci U S A
Invariant natural killer T (iNKT) cells play important roles in regulating immune responses. Based on cytokine profiling and key transcriptional factors, iNKT cells are classified into iNKT1, iNKT2, and iNKT17 subsets. However, whether the developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51486b7c1f2ce4267315d2c1b2d6efc
https://pubmed.ncbi.nlm.nih.gov/34772808
https://pubmed.ncbi.nlm.nih.gov/34772808
Autor:
Shuhang Li, Jiwei Liu, Zhihao Xu, Tengchuan Jin, Rufeng Xue, Rongbin Zhou, Yuanyuan Huang, Shiyu Bai, Jizhong Lou, Junjie Hou, Tao Xu, Li Bai, Linfeng Xu, Fanwu Gong, Linlin Wang, Qielan Wu, Xiaofei Yang, Bolong Lin, Pingyong Xu, Ting Yue, Huimin Zhang, Yanhong Xue
Publikováno v:
Journal of Experimental Medicine. 218
Activation of NLRP3 inflammasome is precisely controlled to avoid excessive activation. Although multiple molecules regulating NLRP3 inflammasome activation have been revealed, the checkpoints governing NLRP3 inflammasome activation remain elusive. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5cad3d83debec4f2cb674e358b2040
https://doi.org/10.1084/jem.20202637
https://doi.org/10.1084/jem.20202637
Autor:
Di Xie, Tao Xu, Xiang Li, Haiming Wei, Qielan Wu, Ting Yue, Wei Ji, Lusheng Gu, Yongdeng Zhang, Li Bai, Huimin Zhang, Yanhong Xue, Lu Wang, Zhilan Liu, Gang Liu, Lili Wang
Publikováno v:
Cellular and Molecular Immunology
The spatiotemporal distribution of cytokines orchestrates immune responses in vivo, yet the underlying mechanisms remain to be explored. We showed here that the spatial distribution of interleukin-4 (IL4) in invariant natural killer T (iNKT) cells re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f4f7dde3d92cd7e257dc0c649694c9
https://doi.org/10.1038/s41423-019-0243-z
https://doi.org/10.1038/s41423-019-0243-z