Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Qiaoyun Chu"'
Autor:
Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc
Publikováno v:
Engineering, Vol 26, Iss , Pp 108-118 (2023)
Immunoglobulin G (IgG) is the most abundant plasma glycoprotein and a prominent humoral immune mediator. Glycan composition affects the affinity of IgG to ligands and consequent immune responses. The modification of IgG N-glycosylation is considered
Externí odkaz:
https://doaj.org/article/256dfb1a547d4d71a08f80f6a427369e
Autor:
Ronghui Yang, Chuanzhen Yang, Lingdi Ma, Yiliang Zhao, Zihao Guo, Jing Niu, Qiaoyun Chu, Yingmin Ma, Binghui Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Reductive stress, reflected by the elevated intracellular NADH/NAD+ ratio, is associated with multiple human diseases. Here, the authors develop a genetic tool to manipulate the ratios of cellular NADH/NAD+ and NADPH/NADP+, and identify purine biosyn
Externí odkaz:
https://doaj.org/article/79f270665f7747d0a6764dc31196bfbb
Publikováno v:
Cancer Medicine, Vol 10, Iss 11, Pp 3689-3699 (2021)
Abstract The marked overexpression of cyclin‐dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic ductal adenocarcinoma (PDAC) development, has been detected in numerous PDAC cell lines and tissues. Although, a pre
Externí odkaz:
https://doaj.org/article/da2107d15ed9483183fd336aaab0ccdc
Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia
Autor:
Yuanyuan Wang, Changsen Bai, Yuxia Ruan, Miao Liu, Qiaoyun Chu, Li Qiu, Chuanzhen Yang, Binghui Li
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Glutamine metabolism is increased in proliferating cells under hypoxia potentially generating exceeding nitrogen. Here the authors show that under hypoxia a specific metabolic pathway is activated to push glutamine carbons and excess nitrogen via the
Externí odkaz:
https://doaj.org/article/4af948245c3a4fd4b6c1e1144b804ba7
Autor:
Qiaoyun Chu, Jing An, Ping Liu, Yihan Song, Xuewei Zhai, Ronghui Yang, Jing Niu, Chuanzhen Yang, Binghui Li
Publikováno v:
Journal of Experimental Medicine. 220
Fatty acid uptake is essential for cell physiological function, but detailed mechanisms remain unclear. Here, we generated an acetyl-CoA carboxylases (ACC1/2) double-knockout cell line, which lacked fatty acid biosynthesis and survived on serum fatty
Publikováno v:
Acta Biochimica et Biophysica Sinica. 54:252-260
Focal adhesion kinase (FAK), a multi-functional cytoplasmic tyrosine kinase, plays a critical role in cancer migration, proliferation and metastasis via regulating multiple signaling pathways. SY-707 is an anaplastic lymphoma kinase (ALK)/FAK/type 1
Autor:
Qiaoyun Chu, Ping Liu, Yihan Song, Ronghui Yang, Jing An, Xuewei Zhai, Jing Niu, Chuanzhen Yang, Binghui Li
Publikováno v:
The EMBO Journal. 42
Reprogramming of lipid metabolism is emerging as a hallmark of cancer, yet involvement of specific fatty acids (FA) species and related enzymes in tumorigenesis remains unclear. While previous studies have focused on involvement of long-chain fatty a
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 11, Pp 3689-3699 (2021)
Cancer Medicine, Vol 10, Iss 11, Pp 3689-3699 (2021)
The marked overexpression of cyclin‐dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic ductal adenocarcinoma (PDAC) development, has been detected in numerous PDAC cell lines and tissues. Although, a previous stu
Publikováno v:
The EPMA journal. 13(3)
Pancreatic cancer presents extremely poor prognosis due to the difficulty of early diagnosis, low resection rate, and high rates of recurrence and metastasis. Immune checkpoint blockades have been widely used in many cancer types but showed limited e
Background Focal adhesion kinase (FAK), a multi-functional cytoplasmic tyrosine kinase, plays a critical role in cancer migration, proliferation and metastasis via regulating multiple signaling pathways. SY-707 is an ALK/FAK/IGF1R multi-kinase inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a48276da4fb7d8b20da2c130e70f8e9
https://doi.org/10.21203/rs.3.rs-148993/v1
https://doi.org/10.21203/rs.3.rs-148993/v1