Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Qiaoyan Yang"'
Autor:
Fang Wang, Weiqi Zhang, Qiaoyan Yang, Yu Kang, Yanling Fan, Jingkuan Wei, Zunpeng Liu, Shaoxing Dai, Hao Li, Zifan Li, Lizhu Xu, Chu Chu, Jing Qu, Chenyang Si, Weizhi Ji, Guang-Hui Liu, Chengzu Long, Yuyu Niu
Publikováno v:
Protein & Cell, Vol 11, Iss 11, Pp 809-824 (2020)
Abstract Many human genetic diseases, including Hutchinson-Gilford progeria syndrome (HGPS), are caused by single point mutations. HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene.
Externí odkaz:
https://doaj.org/article/7a8e00cae52146e1a0fbcd2edf18bf19
CRISPR/Cas9-mediated genome editing in mammalian cells can generate undesired chromosomal alterations, including deleterious on-target large deletions and chromosomal translocations. Currently few approaches effectively prevent these on-target DNA da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3823fe33a92d0e0a2bb2e965946a71ca
https://doi.org/10.1101/2023.01.10.523496
https://doi.org/10.1101/2023.01.10.523496
Autor:
Li Yan, Yu Kang, Chengzu Long, Xue-Ying Gu, Bin Shen, Zhenzhen Chen, Da-Long Zhi, Jianying Wang, Qiaoyan Yang, Yuyu Niu
Publikováno v:
Zoological Research. 42:469-477
Mutations of PTEN-induced kinase I (PINK1) cause early-onset Parkinson’s disease (PD) with selective neurodegeneration in humans. However, current PINK1 knockout mouse and pig models are unable to recapitulate the typical neurodegenerative phenotyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d08845287b9a44476c4c29dd16561b2
https://doi.org/10.24272/j.issn.2095-8137.2021.023
https://doi.org/10.24272/j.issn.2095-8137.2021.023
Autor:
Jing Qu, Qiaoyan Yang, Yanling Fan, Jingkuan Wei, Weiqi Zhang, Lizhu Xu, Zifan Li, Chu Chu, Chenyang Si, Shao-Xing Dai, Yuyu Niu, Zunpeng Liu, Hao Li, Weizhi Ji, Chengzu Long, Guang-Hui Liu, Fang Wang, Yu Kang
Publikováno v:
Protein & Cell, Vol 11, Iss 11, Pp 809-824 (2020)
Protein & Cell
Protein & Cell
Many human genetic diseases, including Hutchinson-Gilford progeria syndrome (HGPS), are caused by single point mutations. HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene. Base edi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcf39d0539ec1a301c24fd3a770f49f
https://doaj.org/article/7a8e00cae52146e1a0fbcd2edf18bf19
https://doaj.org/article/7a8e00cae52146e1a0fbcd2edf18bf19
Autor:
Zebin Mao, Yinglu Li, Xiangyu Liu, Qiaoyan Yang, Tianyun Hou, He Wen, Ying Zhao, Ming Tang, Wei-Guo Zhu, Xiaopeng Lu, Chaohua Liu, Yang Yang, Hui Wang, Meiting Li, Qian Zhu, Zhiming Li, Haiying Wang
Publikováno v:
Theranostics
Background and Aim: DOT1L regulates various genes involved in cancer onset and progression by catalyzing H3K79 methylation, but how DOT1L activity itself is regulated is unclear. Here, we aimed to identify specific DOT1L post-translational modificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a258196888a47fff3ff5675c60da33
http://europepmc.org/articles/PMC6993218
http://europepmc.org/articles/PMC6993218
Autor:
Luo Gu, Ge Liu, Lili Tong, Xiangyu Liu, Xingzhi Xu, Yantao Bao, Hui Wang, Wei-Guo Zhu, Jian Yuan, Qiaoyan Yang, Zheng Li, Xiaopeng Lu, Qian Zhu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance ATR is a central molecule involved in the DNA replication stress response and repair that ensures genome stability. Whether chromatin modifiers or chromatin modifications also regulate ATR activation, however, is unclear. We conclude tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f3fe44fd028a9ad9bc054198b06081
http://europepmc.org/articles/PMC8201831
http://europepmc.org/articles/PMC8201831
Autor:
Qiaoyan Yang, Li Yan, Jianying Wang, Bin Shen, Xue-Ying Gu, Zhenzhen Chen, Da-Long Zhi, Yuyu Niu, Yu Kang
Mutations of PINK1 cause early-onset Parkinson’s disease (PD) with selective neurodegeneration in humans. However,current PINK1 knockout mouse and pig models are unable to recapitulate the typical neurodegenerative phenotypes observed in PD patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37229f745849af0490124c95b33c44d9
https://doi.org/10.1101/2020.10.21.348862
https://doi.org/10.1101/2020.10.21.348862
Autor:
Yantao Bao, Wei-Guo Zhu, Xiaopeng Lu, Chaohua Liu, Yang Yang, He Wen, Ying Zhao, Qiaoyan Yang, Tianyun Hou, Guanqun Mu, Qian Zhu, Lina Wang, Tian Gao, Haiying Wang, Ge Liu, Wei Gu, Meiting Li, Zhiming Li
Publikováno v:
Cell Death and Disease, Vol 9, Iss 10, Pp 1-12 (2018)
The tumor suppressor p53 has critical roles in regulating lipid metabolism, but whether and how p53 regulates cardiolipin (CL) de novo biosynthesis is unknown. Here, we report that p53 physically interacts with histone deacetylase SIRT6 in vitro and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b0d7cd31b5e669a2ddeb0deb79c30b
http://link.springer.com/article/10.1038/s41419-018-0984-0
http://link.springer.com/article/10.1038/s41419-018-0984-0
Autor:
Qiaoyan Yang, Wei-Guo Zhu, Qian Zhu, Chaohua Liu, Bin Peng, Lina Wang, Xiaopeng Lu, Xingzhi Xu, Yinglu Li, Haiying Wang, Meiting Li, Tianyun Hou, Zhiming Li, Ming Tang, Yang Yang, Ying Zhao
Publikováno v:
Cell Research
Linker histone H1 is a master regulator of higher order chromatin structure, but its involvement in the DNA damage response and repair is unclear. Here, we report that linker histone H1.2 is an essential regulator of ataxia telangiectasia mutated (AT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab410b38cfbef881d704165947d607e
http://europepmc.org/articles/PMC6028381
http://europepmc.org/articles/PMC6028381
Autor:
Baohua Liu, He Wen, Qian Zhu, Xingzhi Xu, Ming Tang, Haiying Wang, Tianyun Hou, Yantao Bao, Luo Gu, Ge Liu, Xiaopeng Lu, Ying Zhao, Qiaoyan Yang, Zhongyi Cheng, Wei-Guo Zhu, Yang Yang, Zhiming Li, Yafei Lv
Publikováno v:
Nucleic Acids Research
The binding of p53-binding protein 1 (53BP1) to damaged chromatin is a critical event in non-homologous DNA end joining (NHEJ)-mediated DNA damage repair. Although several molecular pathways explaining how 53BP1 binds damaged chromatin have been desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb2aada06d908dc0e99747877ae5183
https://pubmed.ncbi.nlm.nih.gov/31612207
https://pubmed.ncbi.nlm.nih.gov/31612207