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Akademický článek

Split-design approach enhances the therapeutic efficacy of ligand-based CAR-T cells against multiple B-cell malignancies

Autor: Shuhong Li, Licai Shi, Lijun Zhao, Qiaoru Guo, Jun Li, Ze-lin Liu, Zhi Guo, Yu J. Cao

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract To address immune escape, multi-specific CAR-T-cell strategies use natural ligands that specifically bind multiple receptors on malignant cells. In this context, we propose a split CAR design comprising a universal receptor expressed on T ce

Externí odkaz: https://doaj.org/article/941c6678201d4fd19bf85503ed33843a

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Akademický článek

Adverse Effects of Anti-PD-1/PD-L1 Therapy in Non-small Cell Lung Cancer

Autor: Chaoyue Su, Hui Wang, Yunru Liu, Qiaoru Guo, Lingling Zhang, Jiajun Li, Wenmin Zhou, Yanyan Yan, Xinke Zhou, Jianye Zhang

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Currently, immunotherapy has shown great efficacy in clinical trials, and monoclonal antibodies directed against immune checkpoint PD-1/PD-L1 have shown encouraging results in first-line or second-line treatment of non-small cell lung cancer patients

Externí odkaz: https://doaj.org/article/58ab731872ca415eb6ec8fd152e7b269

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Research Progress of Alzheimer’s Disease Therapeutic Drugs: Based on Renin-Angiotensin System Axis

Autor: Da-Bao Chen, Yan Wang, Qiaoru Guo, Xinquan Li, Guangyun Wang, Wei-Ting Xuan, Hang Song, Hua-Wu Gao, Biao Cai

Publikováno v: Journal of Alzheimer's Disease. 78:1315-1338

It is widely recognized that Alzheimer’s disease (AD) has a complicate link to renin-angiotensin system (RAS). It is known that cerebrovascular disease has some connections with AD, but most of the studies are still conducted in parallel or indepen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8af130c995681e19a896aa5beb9b1d5
https://doi.org/10.3233/jad-200770

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Effect of lathyrol derivatives on non-small cell lung cancer and the possible mechanism

Autor: Yanyan, Yan, Wenmin, Zhou, Qiaoru, Guo, Haiyan, Zhang, Hong, Ji, Luming, Yang, Jianye, Zhang

Publikováno v: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 47(2)

Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancer, with highmorbidity and mortality rate. Nove drug development for NSCLC is urgently needed.This study aims to investigate the activity of lathyrol derivatives and the mechanism fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::165540aa0fb8649f1f79effb64ad85a7
https://pubmed.ncbi.nlm.nih.gov/35545404

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