Distinct non-clock-like signatures of the basal cell carcinomas from three sisters with a lethal Gorlin-Goltz syndrome

Autor: Lihua Ye, Li Wang, Kexin Peng, Ou Fang, Zhen Tian, Caihua Li, Xiaopeng Fu, Qingdong Chen, Jia Chen, Jing Luan, Zhenghua Zhang, Qiaoan Zhang

Publikováno v: BMC Medical Genomics, Vol 15, Iss 1, Pp 1-9 (2022)

Abstract Background Gorlin-Goltz syndrome (GS) is an inherited disease characterized by predisposition to basal cell carcinomas (BCCs) and various developmental defects, whose numerous disease-causing PTCH1 mutations have been identified in the hedge

Externí odkaz: https://doaj.org/article/63cc10a5a6284b20923be292ca252378

Decreased Imiquimod-Induced Psoriasis-Like Skin Inflammation in a Novel MvdF250S/+ Knock-In Mouse Model

Autor: Yumeng La, Wenghong Wong, Kexin Peng, Zhen Tian, Jiewen Pan, Ruilin Sun, Jing Luan, Kexiang Yan, Qiaoan Zhang, Zhenghua Zhang

Publikováno v: Inflammation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19feb64e883cd6f623b2faabc8477f16
https://doi.org/10.1007/s10753-023-01828-z

Up-regulation of BTN3A1 on CD14+cells promotes Vγ9Vδ2 T cell activation in psoriasis

Autor: Jiaqing Zhou, Jingjing Zhang, Lu Tao, Kexin Peng, Qiaoan Zhang, Kexiang Yan, Jing Luan, Jiewen Pan, Xiaohui Su, Jiping Sun, Zhenghua Zhang, Lei Shen

Publikováno v: Proceedings of the National Academy of Sciences. 119

Vγ9Vδ2 T cells play an important role in the development and progression of psoriasis vulgaris (PV), but how they promote skin inflammation and the molecular mechanisms underlying Vγ9Vδ2 T cell dysfunction are poorly understood. Here, we show tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b900eeac0a58133bb0a0f016f5c6214
https://doi.org/10.1073/pnas.2117523119

Mvda is required for zebrafish early development

Autor: Jiewen Pan, Jing Luan, Yu Kong, Wenghong Wong, Qiaoan Zhang, Zhenghua Zhang, Zhuanbin Wu, Kexiang Yan, Yike Huang

Publikováno v: Biological Research v.54 2021
SciELO Chile
CONICYT Chile
instacron:CONICYT
Biological Research, Vol 54, Iss 1, Pp 1-10 (2021)
Biological Research

Background The MVD gene mutations are identified in porokeratosis, which is considered a skin-specific autoinflammatory keratinization disease. However, the biological function of MVD gene remains largely unknown. Therefore, we analyzed the function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e427ecfcdf9a527d35534ec907c1a822
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100217

Establishment of a Mouse Model for Porokeratosis Due to Mevalonate Diphosphate Decarboxylase Deficiency.

Autor: Peng, Kexin¹ (AUTHOR), Wong, Wenghong¹ (AUTHOR), Zhang, Qiaoan¹ (AUTHOR), La, Yumeng¹ (AUTHOR), Tian, Zhen¹ (AUTHOR), Sun, Ruilin² (AUTHOR), Ho, Loksi¹ (AUTHOR), Yang, Kaihang¹ (AUTHOR), Pan, Jiewen¹ (AUTHOR), Luan, Jing¹ (AUTHOR), Niu, Zhenmin³ (AUTHOR) niuzhm@chgc.sh.cn, Zhang, Zhenghua¹ (AUTHOR) verzhang@foxmail.com

Publikováno v: Skin Research & Technology. Sep2024, Vol. 30 Issue 9, p1-11. 11p.