Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Qiao-hong Chen"'
Autor:
Qiao-Hong Chen, V. V. Krishnan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Screening ligands directly binding to an ensemble of intrinsically disordered proteins (IDP) to discover potential hits or leads for new drugs is an emerging but challenging area as IDPs lack well-defined and ordered 3D-protein structures. T
Externí odkaz:
https://doaj.org/article/22f7debeb371435989690ab7df242c36
Autor:
Inderpal Sekhon, Guanglin Chen, Keyara Piri, Seiji Shinkawa, Dennis Ashong, Qiang Zhang, Guangdi Wang, Qiao-Hong Chen
Publikováno v:
Molecules, Vol 28, Iss 12, p 4743 (2023)
Androgen receptor (AR) is a viable therapeutic target for lethal castration-resistant prostate cancer (CRPC), because the continued progression of CRPC is mainly driven by the reactivation of AR transcriptional activity. The current FDA-approved AR a
Externí odkaz:
https://doaj.org/article/b55b50b61e154f0da93eb972b26fc9cb
Autor:
Sitong Wu, Guanglin Chen, Eva Y. Chen, Leyla S. Farshidpour, Qiang Zhang, Guangdi Wang, Qiao-Hong Chen
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 531 (2023)
Silibinin, also known as silybin, is isolated from milk thistle (Silybum marianum). Silibinin has been demonstrated to be a good lead compound due to its potential to prevent and treat prostate cancer. Its moderate potency and poor pharmacokinetic pr
Externí odkaz:
https://doaj.org/article/04afc51a05aa4c3a92eafde352004316
Autor:
Qiongyu Hao, Piwen Wang, Pranabananda Dutta, Seyung Chung, Qun Li, Kun Wang, Jieqing Li, Wei Cao, Wenhong Deng, Qing Geng, Katrina Schrode, Magda Shaheen, Ke Wu, Donghui Zhu, Qiao-Hong Chen, Guanglin Chen, Yahya Elshimali, Jay Vadgama, Yong Wu
Publikováno v:
Cell Death and Disease, Vol 11, Iss 12, Pp 1-18 (2020)
Abstract The abnormal PI3K/AKT/mTOR pathway is one of the most common genomic abnormalities in breast cancers including triple-negative breast cancer (TNBC), and pharmacologic inhibition of these aberrations has shown activity in TNBC patients. Here,
Externí odkaz:
https://doaj.org/article/0cda7630fbaa4ff8a34e820f33a0a735
Publikováno v:
Molecules, Vol 26, Iss 21, p 6421 (2021)
To search for novel androgen receptor (AR) modulators for the potential treatment of castration-resistant prostate cancer (CRPC), naturally occurring silibinin was sought after as a lead compound because it possesses a moderate potency towards AR-pos
Externí odkaz:
https://doaj.org/article/e523de46002940f9b5086286570ef89c
Autor:
Pravien Rajaram, Alyssa Rivera, Kevin Muthima, Nicholas Olveda, Hubert Muchalski, Qiao-Hong Chen
Publikováno v:
Molecules, Vol 25, Iss 10, p 2448 (2020)
Enzalutamide is the first second-generation nonsteroidal androgen receptor (AR) antagonist with a strong binding affinity to AR. Most significantly, enzalutamide can prolong not only overall survival time and metastatic free survival time for patient
Externí odkaz:
https://doaj.org/article/59650abfe51141a5b89ee1df21eb3f9d
Publikováno v:
Molecules, Vol 25, Iss 2, p 362 (2020)
Zampanolide is a promising microtubule-stabilizing agent (MSA) with a unique chemical structure. It is superior to the current clinically used MSAs due to the covalent nature of its binding to β-tubulin and high cytotoxic potency toward multidrug-re
Externí odkaz:
https://doaj.org/article/b64621ec75514e7fa1d123239d6f6caa
Autor:
Kevin B Temeyer, Fan Tong, Maxim M Totrov, Alexander P Tuckow, Qiao-hong Chen, Paul R Carlier, Adalberto A Pérez de León, Jeffrey R Bloomquist
Publikováno v:
Parasites & Vectors, Vol 7, Iss 1, Pp 1-10 (2014)
Abstract Background Phlebotomus papatasi vectors zoonotic cutaneous leishmaniasis. Previous expression of recombinant P. papatasi acetylcholinesterase (PpAChE1) revealed 85% amino acid sequence identity to mosquito AChE and identified synthetic carba
Externí odkaz:
https://doaj.org/article/ac75ae070070468a9f50a55885c01f9b
Autor:
James M. Mutunga, Qiao-Hong Chen, Dawn M. Wong, Polo C-H. Lam, Jianyong Li, Maxim M. Totrov, Aaron D. Gross, Paul R. Carlier, Jeffrey R. Bloomquist
Publikováno v:
CHIMIA, Vol 70, Iss 10 (2016)
Widespread pyrethroid resistance has caused an urgent need to develop new insecticides for control of the malaria mosquito, Anopheles gambiae. Insecticide discovery efforts were directed towards the construction of bivalent inhibitors that occupy bot
Externí odkaz:
https://doaj.org/article/304d974ecc6945a8af3bfffb6f19d76b
Autor:
Bao Vue, Sheng Zhang, Andre Vignau, Guanglin Chen, Xiaojie Zhang, William Diaz, Qiang Zhang, Shilong Zheng, Guangdi Wang, Qiao-Hong Chen
Publikováno v:
Molecules, Vol 23, Iss 12, p 3142 (2018)
As part of our ongoing silybin project, this study aims to introduce a basic nitrogen-containing group to 7-OH of 3,5,20-O-trimethyl-2,3-dehydrosilybin or 3-OH of 5,7,20-O-trimethyl-2,3-dehydrosilybin via an appropriate linker for in vitro evaluation
Externí odkaz:
https://doaj.org/article/bdb572d64a924f9b882be3abdef40736