Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Qiao-Qi Wu"'
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 174-187 (2019)
Background: Soluble amyloid-β oligomer (AβO) induced deleterious cascades have recently been considered to be the initiating pathologic agents of Alzheimer's disease (AD). However, little is known about the neurotoxicity and production of different
Externí odkaz:
https://doaj.org/article/4f9b2ca1693a4cd5aa38bb0a7161edfa
Autor:
Cong-Cong Fu, Xin-Yi Zhang, Liu Xu, Hui-Xian Huang, Shuang Xu, Qiao-Qi Wu, Zhen Wang, Xi Gu, Li-Fang Lin, Song Lin, Ying-Ying Fang, Xiong Cao, Xuemin Wang
ObjectiveEpidemiological studies suggest a bidirectional association between depression and obesity; however, the biological mechanisms that link the development of depression to a metabolic disorder remain unclear. Even though nuclear receptor perox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e354825b6a442060c52fe8260a55c491
https://doi.org/10.21203/rs.3.rs-1144403/v1
https://doi.org/10.21203/rs.3.rs-1144403/v1
Autor:
Wei Qin, Yuanruhua Tian, Wei Wang, Qiao-qi Wu, Tingting Hou, Jianping Jia, Longfei Jia, Haitao Li, Heyun Yang
Publikováno v:
Journal of Alzheimer's disease : JAD. 74(1)
The blood-brain barrier (BBB) can restrict the therapeutic effects of Alzheimer's disease (AD) medications. While a large number of AD drug treatment trials targeting BBB dynamics have emerged, most have failed due to insufficient permeability. Furth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a24b4ea5a7c4e4810336e83f6bb91b
https://pubmed.ncbi.nlm.nih.gov/32007956
https://pubmed.ncbi.nlm.nih.gov/32007956
Publikováno v:
Journal of Alzheimer's Disease. 62:1803-1813
Abnormal amyloid-β (Aβ) aggregates are a striking feature of Alzheimer's disease (AD), and Aβ oligomers have been proven to be crucial in the pathology of AD. Any intervention targeting the generation or aggregation of Aβ can be expected to be us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f77b2b3fcac149ed505871157e09c4
https://doi.org/10.3233/jad-171110
https://doi.org/10.3233/jad-171110
Publikováno v:
Journal of Alzheimer's Disease. 52:1089-1099
Amyloid-β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, and neuroinflammation are major pathophysiological events in Alzheimer's disease (AD). However, the relationships among these processes and which first exerts an effect are unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f6f3c5368de791db1f41d6c4b0fced
https://doi.org/10.3233/jad-160004
https://doi.org/10.3233/jad-160004
Publikováno v:
Journal of neuroscience research. 97(4)
Oxidative stress refers to an imbalance between oxidative and antioxidative systems due to environmental factors. Although oxidative stress is implicated in the pathogenesis of Alzheimer's disease (AD), its precise role is not yet understood. We aime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1532b12a55747c141008d561708ef3
https://pubmed.ncbi.nlm.nih.gov/30461032
https://pubmed.ncbi.nlm.nih.gov/30461032
Autor:
Haitao Li, Qiao-qi Wu, Lingzhi Xu, Tingting Hou, Jianping Jia, Wei Wang, Yiping Wei, Hua-RU-Yuan Tian, Xiu Wang
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5c3fb7174f0e5c2d26e120b84df4ca7
https://doi.org/10.1016/j.jalz.2018.06.231
https://doi.org/10.1016/j.jalz.2018.06.231
Autor:
Haitao Li, Xiu Wang, Yiping Wei, Yuanruhua Tian, Wei Wang, Tingting Hou, Lingzhi Xu, Jianping Jia, Qiao-qi Wu
Publikováno v:
Journal of Alzheimer's disease : JAD. 64(1)
Accumulating evidence has demonstrated that mitochondrial dysfunction is a prominent early event in the progression of Alzheimer's disease (AD). Whether protecting mitochondrial function can reduce amyloid-β oligomer (AβO)-induced neurotoxicity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6f8af6faa195318fd796c5da12a324
https://pubmed.ncbi.nlm.nih.gov/29865070
https://pubmed.ncbi.nlm.nih.gov/29865070