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Akademický článek

The Role of Ferroptosis in Cancer Development and Treatment Response

Autor: Bin Lu, Xiao Bing Chen, Mei Dan Ying, Qiao Jun He, Ji Cao, Bo Yang

Publikováno v: Frontiers in Pharmacology, Vol 8 (2018)

Ferroptosis is a process driven by accumulated iron-dependent lipid ROS that leads to cell death, which is a distinct regulated cell death comparing to other cell death. The lethal metabolic imbalance resulted from GSH depletion or inactivation of gl

Externí odkaz: https://doaj.org/article/935e724ee91b4a91825c9498cdff8557

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Data from Synergistic Antitumor Activity of Gemcitabine and ABT-737 In Vitro and In Vivo through Disrupting the Interaction of USP9X and Mcl-1

Autor: Bo Yang, Qiao-jun He, Neng-ming Lin, Yong-zhou Hu, Xiao-wu Dong, Hai Jiang, Liu-qing Yang, Hong Zhu, Tian-yu Cai, Chong Zhang

The Bcl-2 antagonist ABT-737 targets Bcl-2/Bcl-xL, but not Mcl-1, which may confer resistance to this agent in various cancers with high levels of Mcl-1. Here, we showed that the combination of gemcitabine and ABT-737 exhibited synergistic cytotoxici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc21bba522acfd16e1d4d2120bb3ad8b
https://doi.org/10.1158/1535-7163.c.6535453

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Supplementary Table 1 - 2 from Tirapazamine Sensitizes Hepatocellular Carcinoma Cells to Topoisomerase I Inhibitors via Cooperative Modulation of Hypoxia-Inducible Factor-1α

Autor: Bo Yang, Qiao-Jun He, Jian-Shu Lou, Ling Ding, Jun Zhang, Ji Cao, Hong Zhu, Xiao-Wen Liu, Tian-Yu Cai

PDF file - 135K, Supplementary Table S1. CI Values of SN-38 at Concentrations Applied in Combination with Tirapazamine in Different Liver Cell Lines; Supplementary Table S2. In Vivo Efficacy of CPT-11 in Combination with Tirapazamine; and supplementa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c338e356a43e5fccadf7593aabcfd1
https://doi.org/10.1158/1535-7163.22500610

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Data from CT-707, a Novel FAK Inhibitor, Synergizes with Cabozantinib to Suppress Hepatocellular Carcinoma by Blocking Cabozantinib-Induced FAK Activation

Autor: Hong Zhu, Bo Yang, Qiao-Jun He, Hui Zhang, Ying-Hui Sun, Yong Peng, Yong-Xin Han, Pei-Hua Luo, Jian Ma, Ji Cao, Mei-Dan Ying, Xiao-Yang Dai, Fang-Jie Yan, Zi-Bo Chen, Ying Chen, Dan-Dan Wang

Hepatocellular carcinoma is among the leading causes of cancer-related deaths worldwide, and the development of new treatment regimens is urgently needed to improve therapeutic approach. In our study, we found that the combination of a Met inhibitor,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a8acbb44b4e6f572bdbccfc050ceb1
https://doi.org/10.1158/1535-7163.c.6538797

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Data from Tirapazamine Sensitizes Hepatocellular Carcinoma Cells to Topoisomerase I Inhibitors via Cooperative Modulation of Hypoxia-Inducible Factor-1α

Autor: Bo Yang, Qiao-Jun He, Jian-Shu Lou, Ling Ding, Jun Zhang, Ji Cao, Hong Zhu, Xiao-Wen Liu, Tian-Yu Cai

Topoisomerase I inhibitors are a class of anticancer drugs with a broad spectrum of clinical activity. However, they have limited efficacy in hepatocellular cancer. Here, we present in vitro and in vivo evidence that the extremely high level of hypox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096522284f042fe26aff132c2d4f393e
https://doi.org/10.1158/1535-7163.c.6536518.v1

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