Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Qiansen Zhang"'
Autor:
Huang Chen, Aiwu Bian, Wenbo Zhou, Ying Miao, Jiangnan Ye, Jiahui Li, Peng He, Qiansen Zhang, Yue Sun, Zhenliang Sun, Chaowen Ti, Yihua Chen, Zhengfang Yi, Mingyao Liu
Publikováno v:
ACS Central Science, Vol 10, Iss 3, Pp 579-594 (2024)
Externí odkaz:
https://doaj.org/article/888b0e8e3b9d4a33a0a9847288f2eed5
Autor:
Heng Liu, Maya M. Polovitskaya, Linlin Yang, Meiling Li, Hongyue Li, Zhen Han, Jianguo Wu, Qiansen Zhang, Thomas J. Jentsch, Jun Liao
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112926- (2023)
Summary: Volume-regulated anion channels (VRACs) are hexamers of LRRC8 proteins that are crucial for cell volume regulation. N termini (NTs) of the obligatory LRRC8A subunit modulate VRACs activation and ion selectivity, but the underlying mechanisms
Externí odkaz:
https://doaj.org/article/06096b7a180d4c65b012214fca9c9ff3
Autor:
Weiqiang Lu, Weiwei Yu, Jiacheng He, Wenjuan Liu, Junjie Yang, Xianhua Lin, Yuanjin Zhang, Xin Wang, Wenhao Jiang, Jian Luo, Qiansen Zhang, Huaiyu Yang, Shihong Peng, Zhengfang Yi, Shancheng Ren, Jing Chen, Stefan Siwko, Ruth Nussinov, Feixiong Cheng, Hankun Zhang, Mingyao Liu
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 1, Pp 1-20 (2020)
Abstract Immune checkpoint blockade (ICB) has a limited effect on colorectal cancer, underlining the requirement of co‐targeting the complementary mechanisms. Here, we identified prostaglandin E2 (PGE2) receptor 4 (EP4) as the master regulator of i
Externí odkaz:
https://doaj.org/article/8125259b5cdd424f86cbdecc874e654a
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 4/23/2024, Vol. 121 Issue 17, p1-10, 35p
Autor:
Zhiyuan Cheng, Yijie Wang, Yao Zhang, Chan Zhang, Mengru Wang, Wei Wang, Jiacheng He, Yang Wang, Hankun Zhang, Qiansen Zhang, Chunyong Ding, Deyan Wu, Linlin Yang, Mingyao Liu, Weiqiang Lu
Publikováno v:
Journal of Medicinal Chemistry. 66:6218-6238
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f971885c9b909f7ea192ee812554b3e7
https://doi.org/10.1021/acs.jmedchem.2c02058
https://doi.org/10.1021/acs.jmedchem.2c02058
Autor:
Shijie Liu, Peipei Guo, Kun Wang, Shaoying Zhang, Ya Li, Juwen Shen, Lianghe Mei, Yangliang Ye, Qiansen Zhang, Huaiyu Yang
Publikováno v:
Journal of Medicinal Chemistry. 65:10285-10299
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16d91b64e0cd160ed6819d1cc02b9946
https://doi.org/10.1021/acs.jmedchem.1c02115
https://doi.org/10.1021/acs.jmedchem.1c02115
Autor:
Zhengfang Yi, Mingyao Liu, Yihua Chen, Jianghua Zheng, Zhenliang Sun, Chaowen Ti, Shifen Xu, Jiangnan Ye, Xuan Yin, Ying Miao, Qiansen Zhang, Aiwu Bian, Wenbo Zhou, Huang Chen
Fig. S1. Structure-based ligand discovery of STAT3 inhibitorsFig. S2. Surface plasmon resonance analysis of interactions between WB436B to STATfamily proteinsFig. S3. The biology evaluation of WB436B inactive analogue WB345Fig. S4. The mutation in ST
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd0ea49a3b10b983466a4179a7cd2c0
https://doi.org/10.1158/1078-0432.22490773.v1
https://doi.org/10.1158/1078-0432.22490773.v1
Autor:
Zhengfang Yi, Mingyao Liu, Yihua Chen, Jianghua Zheng, Zhenliang Sun, Chaowen Ti, Shifen Xu, Jiangnan Ye, Xuan Yin, Ying Miao, Qiansen Zhang, Aiwu Bian, Wenbo Zhou, Huang Chen
Purpose:Pancreatic cancer is the worst prognosis among all human cancers, and novel effective treatments are urgently needed. Signal transducer and activator of transcription 3 (STAT3) has been demonstrated as a promising target for pancreatic cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc924dbe246d6b2993e529d69fbaaecc
https://doi.org/10.1158/1078-0432.c.6533215
https://doi.org/10.1158/1078-0432.c.6533215
Autor:
Zhengfang Yi, Mingyao Liu, Yihua Chen, Jianghua Zheng, Zhenliang Sun, Chaowen Ti, Shifen Xu, Jiangnan Ye, Xuan Yin, Ying Miao, Qiansen Zhang, Aiwu Bian, Wenbo Zhou, Huang Chen
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5317f3823843ecc365e94fa428f1ed0
https://doi.org/10.1158/1078-0432.22490770
https://doi.org/10.1158/1078-0432.22490770
Autor:
Zhengfang Yi, Mingyao Liu, Yihua Chen, Jianghua Zheng, Zhenliang Sun, Chaowen Ti, Shifen Xu, Jiangnan Ye, Xuan Yin, Ying Miao, Qiansen Zhang, Aiwu Bian, Wenbo Zhou, Huang Chen
Table S1. List of antibodies used and their technical information Table S2. The sequence of Real-time PCR primersTable S3. The sequence of shRNAs for silencing STAT3 Table S4. The sequence of ChromatinImmunoprecipitation (Ch-IP) PCRTable S5. The bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b423f6667d8bf9ff5b1d4d736dd1f2
https://doi.org/10.1158/1078-0432.22490767.v1
https://doi.org/10.1158/1078-0432.22490767.v1