Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Qianping, Peng"'
Autor:
Anne-Françoise Aubry, Yunlin Fu, Mark E. Arnold, Duxi Zhang, Qianping Peng, Yuan-Qing Xia, Long Yuan
Publikováno v:
Journal of Chromatography B. 969:60-68
A sensitive, accurate and rugged UHPLC–MS/MS method was developed and validated for the quantitation of Epothilone D (EpoD), a microtubule stabilizer in development for treatment of Alzeimer's disease, in rat plasma. The ester group in EpoD can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fea25b8148fd4d9d50f19f5f3266fec
https://doi.org/10.1016/j.jchromb.2014.08.006
https://doi.org/10.1016/j.jchromb.2014.08.006
Autor:
Zheng Ouyang, Qianping Peng, Long Yuan, Mark E. Arnold, Yuan-Qing Xia, Hao Jiang, Anne-Françoise Aubry, Jianing Zeng, Yuzhong Deng, Robert W. Lange
Publikováno v:
Journal of Chromatography B. :81-86
Asunaprevir (BMS-650032) is a potent hepatitis C virus (HCV) non-structural protein protease inhibitor currently in Phase III clinical trials for the treatment of HCV infection. A rugged and accurate LC–MS/MS method was developed and validated for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99335d21a15219ec1ab010ae0514658d
https://doi.org/10.1016/j.jchromb.2013.01.029
https://doi.org/10.1016/j.jchromb.2013.01.029
Autor:
Zheng Ouyang, Mark E. Arnold, Qianping Peng, Naiyu Zheng, Jianing Zeng, Adela Buzescu, Terry Van Vleet, Stephanie Pasas-Farmer, Mohammed Jemal
Publikováno v:
Journal of Chromatography B. :64-74
Automated sample extraction for regulated bioanalysis by liquid chromatography/tandem mass spectrometry (LC-MS/MS) still presents significant challenges. A new sample preparation methodology with a simplified and completely automated workflow was dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fc1d1c7bbb56fbe88f3281b2df2a60
https://doi.org/10.1016/j.jchromb.2013.01.028
https://doi.org/10.1016/j.jchromb.2013.01.028
Autor:
Jack L. Valentine, Robert W. Lange, Hao Jiang, Mark E. Arnold, Qianping Peng, Jianing Zeng, Hamza Kandoussi, Naiyu Zheng
Publikováno v:
Analytical Chemistry. 83:6237-6244
Quantitative determination of drug concentrations in tissue homogenates via liquid chromatography-tandem mass spectrometry (LC-MS/MS) is commonly conducted using the standards and analytical quality controls (QCs) prepared in the same matrix (tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e55c63a590eb83a96126015227b52d
https://doi.org/10.1021/ac200820q
https://doi.org/10.1021/ac200820q
Autor:
Palucki Brenda, Patrick G. Pollard, Liangqin Guo, Tung M. Fong, Matthew J. Wyvratt, Randy R. Miller, Shuwen He, Constantin Tamvakopoulos, Iyassu K. Sebhat, Qianping Peng, Ravi P. Nargund, Zhixiong Ye, Airu S. Chen, Doreen E. Cashen, David H. Weinberg, Min K. Park, Raman K. Bakshi, D. Euan MacIntyre, Howard Y. Chen, Rui Tang, Tanya MacNeil, Qingmei Hong, Alison M. Strack, Ralph A. Stearns, Jian Liu, William J. Martin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2330-2334
We report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound 1 shows anti-obesity efficacy without potentiating erectile activity in the rodent models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99aea0aa624d82cc9bc8f3cfa4bdb369
https://doi.org/10.1016/j.bmcl.2011.02.090
https://doi.org/10.1016/j.bmcl.2011.02.090
Autor:
Yingjie Lai, Ralph A. Stearns, Qianping Peng, Ravi P. Nargund, Qingmei Hong, Jian Liu, Rui Tang, Matthew J. Wyvratt, Raman K. Bakshi, Randy R. Miller, Tianying Jian, Alison M. Strack, Tanya MacNeil, Liangqin Guo, Howard Y. Chen, James Dellureficio, Iyassu K. Sebhat, Peter H. Dobbelaar, Airu S. Chen, Constantin Tamvakopoulos, David H. Weinberg, Tung M. Fong, Christopher L. Franklin, Shuwen He, Zhixiong Ye
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4399-4405
We report a series of potent and selective MC4R agonists based on spiroindane amide privileged structures for potential treatments of obesity. Among the synthetic methods used, Method C allows rapid synthesis of the analogs. The series of compounds c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04db1e6e6855a321002bb787613d21e
https://doi.org/10.1016/j.bmcl.2010.06.062
https://doi.org/10.1016/j.bmcl.2010.06.062
Autor:
Howard Y. Chen, William J. Martin, D. Euan MacIntyre, Zhixiong Ye, Raman K. Bakshi, Alison M. Strack, Doreen E. Cashen, Jian Liu, Yingjie Lai, Tianying Jian, Constantin Tamvakopoulos, Nancy N. Tsou, Shuwen He, James Dellureficio, Tung M. Fong, Peter H. Dobbelaar, David H. Weinberg, Airu S. Chen, Qingmei Hong, Iyassu K. Sebhat, Tanya MacNeil, Christopher L. Franklin, Ravi P. Nargund, Ralph A. Stearns, Rui Tang, Richard G. Ball, Matthew J. Wyvratt, Randy R. Miller, Liangqin Guo, Qianping Peng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2106-2110
We report the design, synthesis and properties of spiroindane based compound 1, a potent, selective, orally bioavailable, non-peptide melanocortin subtype-4 receptor agonist. Compound 1 shows excellent erectogenic activity in the rodent models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecb491322cadefd63c62faedffb60b8
https://doi.org/10.1016/j.bmcl.2010.02.058
https://doi.org/10.1016/j.bmcl.2010.02.058
Autor:
Marc L. Reitman, Cheng Guo, Theresa M. Kelly, Constantin Tamvakopoulos, Joseph M. Metzger, Tianying Jian, Howard Y. Chen, Arthur A. Patchett, Oksana C. Palyha, Alison M. Strack, Allan J. Goodman, Ravi P. Nargund, Peter H. Dobbelaar, Yanqing Kan, Mark Hadden, Larry Yet, Peter R. Guzzo, Qianping Peng, Linus S. Lin, Shuwen He, Lauren P. Shearman, Alan J. Henderson, Carina P. Tan, Sargent Bruce J, Xiao-Ming Guan, Scott D. Feighner, Iyassu K. Sebhat, Jie Pan, Jian Liu, Donald J. Marsh, Matthew J. Wyvratt, Andrew D. Howard, Megan Ruenz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1913-1917
We report SAR studies on a novel non-peptidic bombesin receptor subtype-3 (BRS-3) agonist lead series derived from high-throughput screening hit RY-337. This effort led to the discovery of compound 22e with significantly improved potency at both rode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9388422b542c24893358d41aa77156
https://doi.org/10.1016/j.bmcl.2010.01.154
https://doi.org/10.1016/j.bmcl.2010.01.154
Autor:
Heather L. Sings, Mark T. Goulet, Matthew J. Wyvratt, Iyassu K. Sebhat, Liangqin Guo, Rui Tang, Ravi P. Nargund, Qianping Peng, Euan Macintyre, Feroze Ujjainwalla, Constantin Tamvakopoulos, Zhixiong Ye, Lex H.T. Van der Ploeg, David H. Weinberg, Tanya MacNeil, John Huber
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3242-3247
Discovery of a series of tert-butyl pyrrolidine derived, potent and orally bioavailable melanocortin receptor subtype-4 (MC4R) selective modulators is disclosed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df57b635925179aebc3ae868f442a4cc
https://doi.org/10.1016/j.bmcl.2008.04.049
https://doi.org/10.1016/j.bmcl.2008.04.049
Autor:
Doreen E. Cashen, Constantin Tamvakopoulos, Qianping Peng, William J. Martin, David H. Weinberg, Charles Rosenblum, Arthur A. Patchett, Tanya MacNeil, Patrick G. Pollard, Zhixiong Ye, Raman K. Bakshi, Ralph A. Stearns, Rubana N. Kalyani, Palucki Brenda, Joseph M. Metzger, Alison M. Strack, Lex H.T. Van der Ploeg, D. Euan MacIntyre, Iyassu K. Sebhat, Aurawan Vongs, Airu S. Chen, Ravi P. Nargund, Liangqin Guo, Matthew J. Wyvratt, Randy R. Miller, Rui Tang, Howard Y. Chen, Khaled J. Barakat
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3501-3505
A novel isoquinuclidine containing selective melanocortin subtype-4 receptor small molecule agonist, 3 (RY764), is reported. Its in vivo characterization revealed mechanism-based food intake reduction and erectile activity augmentation in rodents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec96b03aa1e5f2ba3d3c429b0a51544
https://doi.org/10.1016/j.bmcl.2005.05.109
https://doi.org/10.1016/j.bmcl.2005.05.109