Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Qianhe Xu"'
Publikováno v:
Acta Materia Medica, Vol 3, Iss 2, Pp 239-253 (2024)
Elevated cellular oxidative stress is a common marker of cancer cell dysregulation caused by malignant transformation. Thioredoxin reductase (TrxR, encoded by TXNRD) is a crucial enzyme that regulates cellular oxidative stress and the survival of man
Externí odkaz:
https://doaj.org/article/4c32e338cae64a22aefff14f7658d6d1
Autor:
Jingchao Li, Tingting Wang, Yuanfei Shi, Zichen Ye, Xun Zhang, Jiang Ming, Yafei Zhang, Xinyan Hu, Yun Li, Dongsheng Zhang, Qianhe Xu, Jun Yang, Xiaolan Chen, Nian Liu, Xinhui Su
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Radionuclides internal radiotherapy (RIT) is a clinically powerful method for cancer treatment, but still poses unsatisfactory therapeutic outcomes due to the hypoxic characteristic of tumor microenvironment (TME). Catalase (CAT) or CAT-like
Externí odkaz:
https://doaj.org/article/9b0e60d709c843c0ab88b685d7539ec2
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 790-801 (2021)
Isolation and identification of natural products from plants is an essential approach for discovering drug candidates. Herein we report the characterization of three sesquiterpene lactones from a new genus Shangwua, e.g. onopordopicrin (ONP), C2, and
Externí odkaz:
https://doaj.org/article/4972f17579ef47ef9eed14e9d2e0c8da
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Natural products frequently have unique physiological activities and new action mechanisms due to their structural diversity and novelty, and are an important source for innovative drugs and lead compounds. We present herein that natural product sant
Externí odkaz:
https://doaj.org/article/564490780143496a978c8fe034f8bf88
Autor:
Bingbing Chang, Qianhe Xu, Hairui Guo, Miao Zhong, Ruipeng Shen, Lanning Zhao, Jintao Zhao, Tao Ma, Yajun Chu, Junmin Zhang, Jianguo Fang
Publikováno v:
Journal of Medicinal Chemistry. 66:3250-3261
Publikováno v:
Journal of Medicinal Chemistry. 64:17979-17991
A diselenide/disulfide unit was introduced into camptothecin (CPT), and two selenoprodrugs (e.g., CPT-Se3 and CPT-Se4) were identified to show improved potency in killing cancer cells and inhibiting tumor growth in vivo. Interestingly, the intrinsic
Publikováno v:
Journal of Medicinal Chemistry. 64:16132-16146
Upregulation of the selenoprotein thioredoxin reductase (TrxR) is of pathological significance in maintaining tumor phenotypes. Thus, TrxR inhibitors are promising cancer therapeutic agents. We prepared different amino-substituted phenylarsine oxides
Autor:
Chun Zhao, Hao Ren, Xiaolei Wang, Li-Li Tian, Jianguo Fang, Quan-Xiang Wu, Ji-Wen Zhang, Pan-Pan Zhou, Ya-Mei Miao, Qianhe Xu, Chun-Xiao Jiang, Zhen-Qing Yu, Jin Z. Zhang, Bo Yu
Publikováno v:
Journal of Natural Products. 84:2468-2474
Clonorosins A (1) and B (2), two novel indole alkaloids featuring unprecedented 6/5/6/6/5 and 6/5/5 cores, together with seven known indole-linked 2,5-diketopiperazine alkaloids (3-9), were isolated from the soil-derived fungus Clonostachys rosea YRS
Autor:
Chun-Xiao Jiang, Bo Yu, Ya-Mei Miao, Hao Ren, Qianhe Xu, Chun Zhao, Li-Li Tian, Zhen-Qing Yu, Pan-Pan Zhou, Xiaolei Wang, Jianguo Fang, Jiwen Zhang, Jin Z. Zhang, Quan-Xiang Wu
Publikováno v:
Journal of Natural Products. 85:2252-2253
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1869(10)
Thioredoxin reductase (TrxR) is a pivotal regulator of redox homeostasis, while dysregulation of redox homeostasis is a hallmark for cancer cells. Thus, there is considerable potential to inhibit the aberrantly upregulated TrxR in cancer cells to dis