Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Qian-Wen Lin"'
Discovery of Potent and Novel Dual PARP/BRD4 Inhibitors for Efficient Treatment of Pancreatic Cancer
Autor:
Lei Huang, Qian-Wen Lin, Shuping Wang, Qihua Zhu, Qin Sun, Yungen Xu, Shi-Qi Wu, Shi-Hui Huang, Ling-Li Gao, Liu-Qiong Meng, Yi Zou, Yu Li
Publikováno v:
Journal of Medicinal Chemistry. 64:17413-17435
Targeting poly(ADP-ribose) polymerase1/2 (PARP1/2) is a promising strategy for the treatment of pancreatic cancer with breast cancer susceptibility gene (BRCA) mutation. Inducing the deficiency of homologous recombination (HR) repair is an effective
Publikováno v:
Journal of Medicinal Chemistry. 64:11074-11089
The formation of biofilms by clinical pathogens typically leads to chronic and recurring antibiotic-resistant infections. High cellular levels of cyclic diguanylate (c-di-GMP), a ubiquitous secondary messenger of bacteria, have been proven to be asso
Autor:
Bing-Qing Hu, Chao-Yang Li, Meng-Ge Cao, Jun-Jie Wang, Dou-Dou Hu, Ji-Xiang Li, Yi-Ran Fu, Xin-Fang Wang, Yu-Fei He, Qian-Wen Lin
Publikováno v:
Inorganic and Nano-Metal Chemistry. :1-7
A Cd(ΙI)-based luminescent coordination polymer, namely [Cd(L)2(H2O)2]n (1), has been synthesized by 1-(tetrazo-5-yl)-4-(triazo-1-yl)benzene ligand (HL) and structurally characterized. The selectiv...
Autor:
Dou-Dou Hu, Jing-Xia Chen, Yi-Ran Fu, Yu Wang, Meng-Ge Cao, Qian-Wen Lin, Yu-Fei He, Chao-Yang Li, Bing-Qing Hu, Jun-Jie Wang
Publikováno v:
Journal of Coordination Chemistry. 74:1298-1310
Co(II) and Cu(II) complexes, [Co2(H2L)2(phen)2(H2O)4](H2O)2 (1) and [Cu2(L)0.5(phen)2Cl2]n (2) [H4L = 5,5'-(diazene-1,2-diyl)diisophthalic acid, phen = 1,10-phenanthroline], have been solvothermall...
Publikováno v:
Pharmacological research. 175
Inducing homologous recombination (HR) deficiency is a promising strategy to broaden the indication of PARP1/2 inhibitors in pancreatic cancer treatment. In addition to inhibition kinases, repression of the transcriptional function of FOXM1 has been
Autor:
Shi-Hui Huang, Ran Cao, Qian-Wen Lin, Shi-Qi Wu, Ling-Li Gao, Qin Sun, Qi-Hua Zhu, Yi Zou, Yun-Gen Xu, Shu-Ping Wang
Publikováno v:
European Journal of Medicinal Chemistry. 230:114116
Inducing the deficiency of homologous recombination (HR) repair is an effective strategy to broaden the indication of PARP inhibitors in pancreatic cancer treatment. Repression of BRD4 has been reported to significantly elevate HR deficiency and sens