Výsledky vyhledávání - "Qian-Liang Guo"

Synthesis and evaluation of 7-substituted-5,6-dihydrobenzo[ c ]acridine derivatives as new c- KIT promoter G-quadruplex binding ligands

Autor: Qian-Liang Guo, Ding Li, Jia-Heng Tan, Yu-Ting Lu, Zhi-Shu Huang, Hua-Fei Su, Ning Wang, Tian-Miao Ou, Sheng-Rong Liao

Publikováno v: European Journal of Medicinal Chemistry. 130:458-471

It has been shown that treatment of cancer cells with c-KIT G-quadruplex binding ligands can reduce their c-KIT expression levels thus inhibiting cell proliferation and inducing cell apoptosis. Herein, a series of new 7-substituted-5,6-dihydrobenzo[c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673b3a10c084ec3d62cb920dbfc1f0d5
https://doi.org/10.1016/j.ejmech.2017.02.051

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Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair

Autor: Zhi-Shu Huang, Tian-Miao Ou, Shi-Liang Huang, Zi-Lin Zhang, Yu-Qing Wang, Honggen Wang, Jia-Heng Tan, Shuo-Bin Chen, Ding Li, Qi-Kun Yin, Qian-Liang Guo, Chen-Xi Wang

Publikováno v: Journal of medicinal chemistry. 62(6)

Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that performs an important role in HRR regulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9078aef2ba86a9e536d6207ca905eb
https://pubmed.ncbi.nlm.nih.gov/30827110

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Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment

Autor: Tian-Miao Ou, Chun-Li Xia, Shi-Liang Huang, Zhen-Quan Liu, Honggen Wang, Zhi-Shu Huang, Jia-Qiang Wu, Jia-Heng Tan, Ning Wang, Ding Li, Qian-Liang Guo

Publikováno v: European journal of medicinal chemistry. 130

A series of 2-arylethenyl-N-methylquinolinium derivatives were designed and synthesized based on our previous research of 2-arylethenylquinoline analogues as multifunctional agents for the treatment of Alzheimer's disease (AD) (Eur. J. Med. Chem. 201

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0e57f2bb4926b7df453de7e3ae6c6d
https://pubmed.ncbi.nlm.nih.gov/28242549

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