Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Qian Yue Zhang"'
Autor:
Ya Fang, Jia-Ping Wan, Zheng Wang, Shi-Yang Song, Cao-Xu Zhang, Liu Yang, Qian-Yue Zhang, Chen-Yan Yan, Feng-Yao Wu, Sang-Yu Lu, Feng Sun, Bing Han, Shuang-Xia Zhao, Mei Dong, Huai-Dong Song
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The mechanisms of bifurcation, a key step in thyroid development, are largely unknown. Here we find three zebrafish lines from a forward genetic screening with similar thyroid dysgenesis phenotypes and identify a stop-gain mutation in hgfa a
Externí odkaz:
https://doaj.org/article/03b13e80251642c59ec1b2d152a4907c
Autor:
Chen-Yan Yan, Feng-Yao Wu, Feng Sun, Ya Fang, Rui-Jia Zhang, Chang-Run Zhang, Cao-Xu Zhang, Zheng Wang, Rui-Meng Yang, Liu Yang, Mei Dong, Qian-Yue Zhang, Xiao-Ping Ye, Huai-Dong Song, Shuang-Xia Zhao
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundISL LIM homeobox 2, also known as insulin gene enhancer protein ISL-2 (ISL2), is a transcription factor gene that participates in a wide range of developmental events. However, the role of ISL2 in the hypothalamus-pituitary-thyroid axis is
Externí odkaz:
https://doaj.org/article/7a8f1f2241c245beb06b935adfe28b4e
Autor:
Chang-Run Zhang, Yuan-Ping Shi, Cao-Xu Zhang, Feng Sun, Wen-Jiao Zhu, Rui-Jia Zhang, Ya Fang, Qian-Yue Zhang, Chen-Yan Yan, Ying-Xia Ying, Shuang-Xia Zhao, Huai-Dong Song
Publikováno v:
JCRPE, Vol 14, Iss 1, Pp 46-55 (2022)
INTRODUCTION: Defects in the human solute carrier family 26 member 4 (SLC26A4) gene are reported to be one of the causes of congenital hypothyroidism (CH). We aimed to identify SLC26A4 mutations in Chinese patients with CH and analyze the function of
Externí odkaz:
https://doaj.org/article/22c7539fc88e49b983236c3e31d4840f
Autor:
Qian-Yue Zhang, Xiao-Ping Ye, Zheng Zhou, Chen-Fang Zhu, Rui Li, Ya Fang, Rui-Jia Zhang, Lu Li, Wei Liu, Zheng Wang, Shi-Yang Song, Sang-Yu Lu, Shuang-Xia Zhao, Jian-Nan Lin, Huai-Dong Song
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Hashimoto’s Thyroiditis is an autoimmune disease with a complex pathomechanism. Authors here show by single cell RNA sequencing that the thyroidal microenvironment in the disease is characterised by three stromal cell subtypes that are potentially
Externí odkaz:
https://doaj.org/article/9efe0aed643e40f0a6d940fc628988fe
Autor:
Na He, Li Li, Rui Li, Si-Qi Zhang, Li-Hong Wu, Xian Guan, Qian-Yue Zhang, Tao Jiang, Jin-Bo Yang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8859 (2023)
The Janus kinase/signal transducer and activator of the transcription 3 (JAK/STAT3) signaling pathway controls multiple biological processes, including cell survival, proliferation, and differentiation. Abnormally activated STAT3 signaling promotes t
Externí odkaz:
https://doaj.org/article/6e8bc313544441df93a4bcd388915b5a
Publikováno v:
Marine Drugs, Vol 21, Iss 4, p 218 (2023)
The JAK/STAT3 signaling pathway is aberrantly hyperactivated in many cancers, promoting cell proliferation, survival, invasiveness, and metastasis. Thus, inhibitors targeting JAK/STAT3 have enormous potential for cancer treatment. Herein, we modified
Externí odkaz:
https://doaj.org/article/f9f1d5ddb9834265b1d3cb10085ad02e
Autor:
Sang-Yu Lu, Ying-Chao Chen, Jia-Lin Feng, Qin-Yi Zhou, Jing Chen, Chen-Fang Zhu, Miao-Miao Guo, Man-Man Zhang, Qian-Yue Zhang, Meng Lu, Liu Yang, Jing Wu, Shuang-Xia Zhao, Huai-Dong Song, Xiao-Ping Ye
Publikováno v:
International Journal of Endocrinology, Vol 2022 (2022)
Background. BRAF exon 15 p.V600E (BRAF V600E) mutation has been established as an important molecular marker for papillary thyroid carcinoma diagnosis by ultrasound-guided fine-needle aspiration biopsy (FNAB). Sanger sequencing is the gold standard f
Externí odkaz:
https://doaj.org/article/70cff3e2d5d24d968ae59897199e6d94
Autor:
Chen‐Yan Yan, Yu‐Ru Ma, Feng Sun, Rui‐Jia Zhang, Ya Fang, Qian‐Yue Zhang, Feng‐Yao Wu, Shuang‐Xia Zhao, Huai‐Dong Song
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 7, Pp n/a-n/a (2020)
Abstract Background With several susceptibility single nucleotide polymorphisms identified by case–control association studies, Graves’ disease is one of the most common forms of autoimmune thyroid disease. In this study, we aimed to determine wh
Externí odkaz:
https://doaj.org/article/aa80589698d34e87b32f4b305aff963e
Autor:
Wenjiao Zhu, Cao-Xu Zhang, Rui-Jia Zhang, Ya Fang, Feng Sun, Qian-Yue Zhang, Chang-Run Zhang, Huai-Dong Song, Ying-Xia Ying, Chen-Yan Yan, Shuang-Xia Zhao, Yuan-Ping Shi
Publikováno v:
Journal of Clinical Research in Pediatric Endocrinology. 14:46-55
Objective Defects in the human solute carrier family 26 member 4 (SLC26A4) gene are reported to be one of the causes of congenital hypothyroidism (CH). We aimed to identify SLC26A4 mutations in Chinese patients with CH and analyze the function of the
Autor:
Jun Hua Ma, Huai Dong Song, Cui Xia Zheng, Ping Li, Ying Ru, Qian Yue Zhang, Bin Su, Shuang Xia Zhao, Xue Song Li, Huang Ming Cao, Fei Sun, Hui Min Yu
Publikováno v:
Aging (Albany NY)
Mimecan encodes a secretory protein that is secreted into the human serum as two mature proteins with molecular masses of 25 and 12 kDa. We found 12-kDa mimecan to be a novel satiety hormone mediated by the upregulation of the expression of interleuk