Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Qian Ru Du"'
Autor:
Nannan Wang, Mei Huang, To Sing Fung, Qiong Luo, Jun Xian Ye, Qian Ru Du, Liang Hai Wen, Ding Xiang Liu, Rui Ai Chen
Publikováno v:
Frontiers in Veterinary Science, Vol 7 (2020)
Genotype-matched vaccines provide ideal protection against infection caused by new Newcastle disease virus (NDV) genotypes or variants even in the vaccinated chickens. In this study, we report a protocol for attenuation and rapid development of a vel
Externí odkaz:
https://doaj.org/article/1023796a573e4ffb91c8a96301389286
Autor:
Chang-Po Zhao, Hai-Liang Zhu, Jian Sun, Jing-Ran Li, Qian-Ru Du, Hua-Lin Yang, Fei Fang, Dong-Dong Li
Publikováno v:
Med. Chem. Commun.. 5:219-225
Due to the increasing evidence linking the PI3Kγ pathway to various disease states, PI3Kγ is becoming an important target for cancer treatment. Herein we designed and synthesized a novel series of N,4-diphenylpyrimidin-2-amine derivatives with low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d670fc99f77aa37b410f5ff2c958631
https://doi.org/10.1039/c3md00301a
https://doi.org/10.1039/c3md00301a
Autor:
Qian-Ru Du, Yan-Ting Wang, Xian-Hai Lv, Dong-Dong Li, Han-Yue Qiu, Jian Sun, Hai-Liang Zhu, Yong-Hua Yang
Publikováno v:
European Journal of Medicinal Chemistry. 68:1-9
It was discovered that a number of cyclin dependent kinase inhibitors containing the pyrazole core structure exhibited high inhibitory potency against broad-range CDKs and corresponding anti-proliferative activities. This information guided us to des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c1f902da8ac41c44b5861d13bf2f75
https://doi.org/10.1016/j.ejmech.2013.07.003
https://doi.org/10.1016/j.ejmech.2013.07.003
Publikováno v:
Sensors and Actuators B: Chemical. 182:498-503
We report a sensitive and selective fluorescent probe SFP-BC for hydrogen sulfide detection based on BODIPY–coumarin platform. SFP-BC shows a significant emission increase in the fast response to sulfide at physiological pH. Utilizing this probe, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59de5f88565a4ba9bc11ef4f62817250
https://doi.org/10.1016/j.snb.2013.03.031
https://doi.org/10.1016/j.snb.2013.03.031
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5870-5875
It had been reported that some dioxygenated rings fusing with the quinazoline scaffold could lead to new EGFR inhibitors. Based on this, several kinds of oxygenated alkane quinazoline derivatives were synthetized and evaluated as EGFR inhibitors. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c912b0f067990d33232833839dc46d6c
https://doi.org/10.1016/j.bmcl.2012.07.079
https://doi.org/10.1016/j.bmcl.2012.07.079
Publikováno v:
Organicbiomolecular chemistry. 11(48)
A series of 4,6-substituted-(diaphenylamino)quinazolines as c-Src inhibitors have been prepared and their biological activity has also been evaluated. All the compounds displayed potential antiproliferation activities, with IC50 values ranging from 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2510eb74d555b37cb8983b9eb2e270c7
https://pubmed.ncbi.nlm.nih.gov/24178241
https://pubmed.ncbi.nlm.nih.gov/24178241
Publikováno v:
Organicbiomolecular chemistry. 11(44)
A series of novel 4-alkoxyquinazoline derivatives were prepared and synthesized and their biological activities were evaluated as potential inhibitors of vascular endothelial growth factor receptor 2 (VEGFR2). Of these compounds, compound 3j demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7b5751515efa62f1d78dec6585d870
https://pubmed.ncbi.nlm.nih.gov/24108070
https://pubmed.ncbi.nlm.nih.gov/24108070
Autor:
Hai-Bin Gong, Yong Qian, Ya-Juan Qin, Hai-Liang Zhu, Jian Sun, Jing-Ran Li, Fei Fang, Dong-Dong Li, Qian-Ru Du
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 8, p e69427 (2013)
PLoS ONE, Vol 8, Iss 8, p e69427 (2013)
4-Anilinoquinazolines as an important class of protein kinase inhibitor are widely investigated for epidermal growth factor receptor (EGFR) tyrosine kinase or epidermal growth factor receptor 2 (HER2) inhibition. A series of novel 6-salicyl-4-anilino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fda0c592ffa2cd09ee92edcb3d7edf8
http://europepmc.org/articles/PMC3731256
http://europepmc.org/articles/PMC3731256
Autor:
Jian Sun, Jing-Ran Li, Fei Fang, Jing-Jun Dong, Wei-Ming Zhang, Dong-Dong Li, Hai-Liang Zhu, Rong-Rong Wang, Qian-Ru Du
Publikováno v:
European journal of medicinal chemistry. 75
Components of fatty acid biosynthetic pathway have been identified as attractive targets for the development of new antibacterial agents. Compounds of series A (4a–4g) and series B (5a–5g) were synthesized by the formation of an amine bond betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3b83711940232615b1482670f100e0
https://pubmed.ncbi.nlm.nih.gov/24561667
https://pubmed.ncbi.nlm.nih.gov/24561667
Autor:
Jian Sun, Hai-Liang Zhu, Hai-Bin Gong, Wei-Qing Zhong, Fei Fang, Dong-Dong Li, Ya-Zhou Pi, Jing-Ran Li, Qian-Ru Du
Publikováno v:
Bioorganicmedicinal chemistry. 21(8)
A series of novel 1,3,4-oxadiazole thioether derivatives (compounds 9-44) were designed and synthesized as potential inhibitors of thymidylate synthase (TS) and as anticancer agents. The in vitro anticancer activities of these compounds were evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da14e5b6582da476e6eb20b06c1384f4
https://pubmed.ncbi.nlm.nih.gov/23490159
https://pubmed.ncbi.nlm.nih.gov/23490159