Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Qi-long Ying"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Introduction: Mouse embryonic stem cell (ESC) self-renewal can be maintained through dual inhibition of GSK3 and MEK kinases. MEK has two highly homologous downstream kinases, extracellular signal-regulated kinase 1 and 2 (ERK1/2). However, the exact
Externí odkaz:
https://doaj.org/article/7d21ad1abf414db48925cd588cc94f5f
Autor:
Junfeng Jiang, Tao Zeng, Li Zhang, Xingfei Fan, Qishu Jin, Haitao Ni, Yusheng Ye, Lipeng Cheng, Li Li, Liujun Wang, Sha Xu, Yu Yang, Juan Gu, Bing Guo, Lei Wang, Xin Li, Yingyi Qin, Jiaxi Li, Jinjiang Wang, Xi Chen, Minjuan Wu, Qi-long Ying, Xingjun Qin, Yefei Wang, Yue Wang
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-8 (2022)
Highlights Cas9 RNA functions as a miRNA sponge. Let-7 is the dominant regulated miRNA by Cas9 RNA. RNA sequence optimization of Cas9 by synonymous mutation improves its safety.
Externí odkaz:
https://doaj.org/article/8fe7ac32766e436bb70ab060b5e9d6e8
Publikováno v:
Stem Cell Reports, Vol 9, Iss 3, Pp 732-741 (2017)
Mouse epiblast stem cells (mEpiSCs) and human embryonic stem cells (hESCs) are primed pluripotent stem cells whose self-renewal can be maintained through cytoplasmic stabilization and retention of β-catenin. The underlying mechanism, however, remain
Externí odkaz:
https://doaj.org/article/414631d1e9544a35a7e51de1ed0618b0
Autor:
Qi-Long Ying, Austin Smith
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1457-1464 (2017)
Embryonic stem cells (ESCs) are a unique tool for genetic perturbation of mammalian cellular and organismal processes additionally in humans offer unprecedented opportunities for disease modeling and cell therapy. Furthermore, ESCs are a powerful sys
Externí odkaz:
https://doaj.org/article/cacf9f1dc95242c7a218e47a787e42cf
Autor:
Shoudong Ye, Tao Zhang, Chang Tong, Xingliang Zhou, Kan He, Qian Ban, Dahai Liu, Qi-Long Ying
Publikováno v:
Biology Open, Vol 6, Iss 4, Pp 511-517 (2017)
Mouse and rat embryonic stem cell (ESC) self-renewal can be maintained by dual inhibition of glycogen synthase kinase 3 (GSK3) and mitogen-activated protein kinase kinase (MEK). Inhibition of GSK3 promotes ESC self-renewal by abrogating T-cell factor
Externí odkaz:
https://doaj.org/article/ba3605cec2f64ba5a095750b8f80a2da
Publikováno v:
Stem Cell Reports, Vol 5, Iss 3, Pp 314-322 (2015)
Activation of Wnt/β-catenin signaling can induce both self-renewal and differentiation in naive pluripotent embryonic stem cells (ESCs). To gain insights into the mechanism by which Wnt/β-catenin regulates ESC fate, we screened and characterized it
Externí odkaz:
https://doaj.org/article/b8b413727aed4c3c823d22f392b87ae1
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185714 (2017)
Activation of signal transducer and activator of transcription 3 (STAT3) by leukemia inhibitory factor (LIF) maintains mouse embryonic stem cell (mESC) self-renewal. Our previous study showed that trans-acting transcription factor 5 (Sp5), an LIF/STA
Externí odkaz:
https://doaj.org/article/d79f63e2da45447fba040a24047ebd64
Publikováno v:
Biology Open, Vol 3, Iss 10, Pp 958-965 (2014)
Stat3 is essential for mouse embryonic stem cell (mESC) self-renewal mediated by LIF/gp130 receptor signaling. Current understanding of Stat3-mediated ESC self-renewal mechanisms is very limited, and has heretofore been dominated by the view that Sta
Externí odkaz:
https://doaj.org/article/18b6d7630127481191d9890336bb613c
Autor:
Mingu Hong, Eunson Jung, Sara Yang, Wonhyuek Jung, Young Jin Seong, Eunkyung Park, Athanasios Bramos, Kyu Eui Kim, Sunju Lee, George Daghlian, Jung In Seo, Inho Choi, In-Seon Choi, Chester J Koh, Agnieszka Kobielak, Qi-Long Ying, Maxwell Johnson, Daniel Gardner, Alex K Wong, Dongwon Choi, Young-Kwon Hong
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157126 (2016)
Several lymphatic reporter mouse lines have recently been developed to significantly improve imaging of lymphatic vessels. Nonetheless, the usage of direct visualization of lymphatic vessels has not been fully explored and documented. Here, we charac
Externí odkaz:
https://doaj.org/article/387d8fb6ca8c4dd1a9f160df3ef21616
Publikováno v:
Stem Cells International, Vol 2015 (2015)
Activation of Wnt signaling enhances self-renewal of mouse embryonic and neural stem/progenitor cells. In contrast, undifferentiated ES cells show a very low level of endogenous Wnt signaling, and ectopic activation of Wnt signaling has been shown to
Externí odkaz:
https://doaj.org/article/22666b1628534f27b038f52aa2328dfe