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Akademický článek

Trilobatin, a Natural Food Additive, Exerts Anti-Type 2 Diabetes Effect Mediated by Nrf2/ARE and IRS-1/GLUT2 Signaling Pathways

Autor: Yan-Ling Shi, Yue-Ping Zhang, Huan Luo, Fan Xu, Jian-Mei Gao, Jing-Shan Shi, Qi-Hai Gong

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Oxidative stress and aberrant insulin signaling transduction play vital roles in type 2 diabetes mellitus (T2DM). Our previous research has demonstrated that trilobatin (TLB), derived from the leaves of Lithocarpus Polystachyus (Wall.), exhibits a po

Externí odkaz: https://doaj.org/article/5f83f567d89f415fa00feb73c94039d6

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Akademický článek

The Optimal Adjuvant Strategy of Aidi Injection With Gemcitabine and Cisplatin in Advanced Non–small Cell Lung Cancer: A Meta-analysis of 70 Randomized Controlled Trials

Autor: Cheng-Qiong Wang, Xiao-Tian Zheng, Xiao-Fan Chen, Hong Jiang, Jun Huang, Yuan Jiang, Shan-Shan Hu, Xiao-Rong Huang, Shi-Yu Liu, Qi-Hai Gong, Ji-Hong Feng, Xue Xiao, Xiao-Fei Li, Zheng Xiao

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Introduction: Aidi injection (Aidi) is composed of cantharidin, astragaloside, ginsenoside, and elentheroside E. As an important adjuvant therapy, Aidi in combination with gemcitabine and cisplatin (GP) is often used in the treatment of non-small cel

Externí odkaz: https://doaj.org/article/f4bdd70b63e74f5a99e31ee5ddb27d4f

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Akademický článek

Trilobatin, a Component from Lithocarpus polystachyrus Rehd., Increases Longevity in C. elegans Through Activating SKN1/SIRT3/DAF16 Signaling Pathway

Autor: Na Li, Xi Li, Yan-Ling Shi, Jian-Mei Gao, Yu-Qi He, Fei Li, Jing-Shan Shi, Qi-Hai Gong

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Trilobatin (TLB) is an effective component from Lithocarpus polystachyrus Rehd. Our previous study revealed that TLB protected against oxidative injury in neuronal cells by AMPK/Nrf2/SIRT3 signaling pathway. However, whether TLB can delay aging remai

Externí odkaz: https://doaj.org/article/f6038d95b94b44b4b032cab88d80ea04

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Akademický článek

Osthole Alleviates Neointimal Hyperplasia in Balloon-Induced Arterial Wall Injury by Suppressing Vascular Smooth Muscle Cell Proliferation and Downregulating Cyclin D1/CDK4 and Cyclin E1/CDK2 Expression

Autor: Yi-Qi Li, Ye-Li Li, Xiao-Tong Li, Jun-Yuan Lv, Yang Gao, Wen-Na Li, Qi-Hai Gong, Dan-Li Yang

Publikováno v: Frontiers in Physiology, Vol 11 (2021)

Percutaneous coronary intervention (PCI) is the most widely used therapy for treating ischemic heart disease. However, intimal hyperplasia and restenosis usually occur within months after angioplasty. Modern pharmacological researchers have proven th

Externí odkaz: https://doaj.org/article/10164788e7174b79b58e107276e5018c

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Akademický článek

Protective effects of Dendrobium nobile Lindl. alkaloids on amyloid beta (25–35)-induced neuronal injury

Autor: Wei Zhang, Qin Wu, Yan-liu Lu, Qi-hai Gong, Feng Zhang, Jing-shan Shi

Publikováno v: Neural Regeneration Research, Vol 12, Iss 7, Pp 1131-1136 (2017)

Dendrobium nobile Lindl. alkaloids (DNLA), the active ingredients of a traditional Chinese medicine Dendrobium, have been shown to have anti-oxidative effects, anti-inflammatory action, and protective effect on neurons against oxygen-glucose deprivat

Externí odkaz: https://doaj.org/article/fbfa47f714114735b692b0738ab1b8f4

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Akademický článek

Sodium ferulate inhibits myocardial hypertrophy induced by abdominal coarctation in rats: Involvement of cardiac PKC and MAPK signaling pathways

Autor: Min Luo, Pan-pan Chen, Lu Yang, Peng Wang, Yan-liu Lu, Fu-guo Shi, Yang Gao, Shang-fu Xu, Qi-hai Gong, Rui-xia Xu, Jiang Deng

Publikováno v: Biomedicine & Pharmacotherapy, Vol 112, Iss , Pp - (2019)

Sodium ferulate (SF) is the sodium salt of ferulic acid which is an active ingredient of Radix Angelica Sinensis and Ligusticum chuanxiong hort. Here, we investigated SF inhibition in a rat model of myocardial hypertrophy induced by coarctation of th

Externí odkaz: https://doaj.org/article/22fc887427f9415a8f01db050b45b9aa

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Akademický článek

Gastrodin Attenuates Bilateral Common Carotid Artery Occlusion-Induced Cognitive Deficits via Regulating Aβ-Related Proteins and Reducing Autophagy and Apoptosis in Rats

Autor: Bo Liu, Jian-Mei Gao, Fei Li, Qi-Hai Gong, Jing-Shan Shi

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Gastrodin (GAS), an active constituent extracted from Gastrodia elata Blume, is used to treat ischemic stroke, epilepsy, dizziness, and dementia for centuries in China. This study examined its effects on vascular dementia (VD) and the underlying mole

Externí odkaz: https://doaj.org/article/4e0ebcdb982c42688d2af36f0e9cd2b7

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Akademický článek

Hydrogen sulfide attenuated tumor necrosis factor-α-induced inflammatory signaling and dysfunction in vascular endothelial cells.

Autor: Li-Long Pan, Xin-Hua Liu, Qi-Hai Gong, Dan Wu, Yi-Zhun Zhu

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e19766 (2011)

Hydrogen sulfide (H(2)S), the third physiologically relevant gaseous molecule, is recognized increasingly as an anti-inflammatory mediator in various inflammatory conditions. Herein, we explored the effects and mechanisms of sodium hydrosulfide (NaHS

Externí odkaz: https://doaj.org/article/d2f27cb3fef344c9a94c3851f816fda4

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