Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Qi-Zheng Yao"'
Discovery of potent HDAC2 inhibitors based on virtual screening in combination with drug repurposing
Publikováno v:
Journal of Molecular Structure. 1247:131399
Histone deacetylase 2 (HDAC2) is a vital therapeutic target for cancer and neurodegenerative diseases. Although some highly effective HDAC2 inhibitors were developed, their serious side effects and toxicity have not been well resolved. Currently, dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::734fccff1b87ab2f3cc01f408415a6ef
https://doi.org/10.1016/j.molstruc.2021.131399
https://doi.org/10.1016/j.molstruc.2021.131399
Autor:
Xin Hua Liu, Yang Wang, Wen Jian Tang, Cheng Xiou, Jing Bo Shi, Qi Zheng Yao, Liu Zeng Chen, Hai Pin Zhou
Publikováno v:
European Journal of Medicinal Chemistry. 124:729-739
Based on telomerase, thirteen novel phenstatin moiety linked stavudine derivatives (8a∼8e and 11a∼11f) were synthesized. The structures were determined by NMR and TOF-HRMS. The screening results showed that some compounds had better anti-cancer a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6eeed9174183a9f51e8c45edae7b85b
https://doi.org/10.1016/j.ejmech.2016.09.011
https://doi.org/10.1016/j.ejmech.2016.09.011
Autor:
Qi-Zheng Yao, Xiaojuan Xu
Publikováno v:
Archiv der Pharmazie. 349:224-231
A scaffold hopping approach was exploited to guide the discovery of a series of pyridine derivatives as novel cyclin-dependent kinase (CDK2) inhibitors. These new compounds were designed, synthesized, and evaluated as CDK2 inhibitors. Most of the com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4279f713ae42a049d3d074bcf8ea74c0
https://doi.org/10.1002/ardp.201500335
https://doi.org/10.1002/ardp.201500335
Publikováno v:
Journal of Molecular Structure. 1087:51-59
We have prepared N1-ethyl-5′-bromo-7-azaindirubin-3′-oxime due to its potential for being a pharmaceutical. Infrared and Raman spectra have been recorded and vibrational assignments have been suggested based mainly on our previous vibrational inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e50e70f45759f7a4b9101242bfeda48e
https://doi.org/10.1016/j.molstruc.2015.01.036
https://doi.org/10.1016/j.molstruc.2015.01.036
Publikováno v:
Letters in Drug Design & Discovery. 12:117-123
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fc4dcd828831a4e3ebd264d7bee9b4e
https://doi.org/10.2174/1570180811666140909010017
https://doi.org/10.2174/1570180811666140909010017
Publikováno v:
Canadian Journal of Chemistry. 91:1009-1017
Many experimental studies have previously found that flavonoids including luteolin can inhibit the activities of matrix metalloproteinases (MMPs), but the related theoretical studies are rather lacking. In this paper, based on our recently obtained i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::119af28cc35c45f6216aba8f094dfd81
https://doi.org/10.1139/cjc-2013-0140
https://doi.org/10.1139/cjc-2013-0140
Publikováno v:
Journal of Molecular Structure. 1048:51-58
For centuries Danggui Longhui Wan has been used to treat chronic ailments, such as myelocytic leukemia. In the 1960s, the active ingredient in Danggui Longhui Wan was isolated and identified as indirubin. Indirubin has shown potent inhibition of cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea623020f4b2f6f85c4cb002eb8177ec
https://doi.org/10.1016/j.molstruc.2013.05.012
https://doi.org/10.1016/j.molstruc.2013.05.012
Publikováno v:
Chinese Chemical Letters. 22:899-902
New pyrimidine nucleoside derivatives with nitric oxide (NO) donor were systematically synthesized. The antivirus activities of these nucleoside analogues against vesicular stomatitis virus (VSV) in Wish cell were evaluated. It was demonstrated that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a052bc34b0b284b85469f07b1cc7140
https://doi.org/10.1016/j.cclet.2011.01.010
https://doi.org/10.1016/j.cclet.2011.01.010
Publikováno v:
Chinese Chemical Letters. 21:297-300
A series of novel 7′-azaindirubin ( 1a – g ) and 7-azaindirubin ( 2a , 2c , 2e and 2f ) derivatives were designed and synthesized. Their structures were characterized by 1 H NMR and MS spectroscopy as well as by elemental analysis. Their inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a68a1fb1bd64bf66dca990afa4b44ff2
https://doi.org/10.1016/j.cclet.2009.11.029
https://doi.org/10.1016/j.cclet.2009.11.029
Publikováno v:
Chinese Chemical Letters. 20:542-544
Twenty 7-azaindirubin derivatives were designed and synthesized. Their antitumor activities were evaluated in vitro against DU145 cell line. The pharmacological results showed that most of the prepared compounds displayed the excellent activity. Comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe789c0fc29fc96e3263b3be9608b9bb
https://doi.org/10.1016/j.cclet.2008.12.011
https://doi.org/10.1016/j.cclet.2008.12.011