Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Qi-Zheng Sun"'
Publikováno v:
Acta Crystallographica Section E, Vol 67, Iss 4, Pp o754-o754 (2011)
In the title compound, C11H14N2O3, an intermolecular interaction between a nitro group O atom and a neighboring benzene ring helps to stabilize the crystal structure [N...centroid = 3.933 (2) Å]. No classical hydrogen bonds are observed in the cryst
Externí odkaz:
https://doaj.org/article/9020022cdb1f400391614faeb58f61fb
Publikováno v:
Theranostics
The influenza pandemic is a major threat to human health, and highly aggressive strains such as H1N1, H5N1 and H7N9 have emphasized the need for therapeutic strategies to combat these pathogens. Influenza anti-viral agents, especially active small mo
Autor:
Zhi-Xing Cao, Shengyong Yang, Wei-Wei Li, Qi-Zheng Sun, Shao-Hua Yao, Jin-Feng Shang, Hui-Wen Yang, Xin Chen, Chuan Cheng
Publikováno v:
Melanoma Research. 26:117-124
Melanoma is a type of cancer arising from the melanocytes, which are the cells that make up the pigment melanin and are derived from the neural crest. There is no particularly effective therapy once the disease is metastatic, highlighting the need fo
Autor:
Guangwen Lu, Yuquan Wei, Chong Chen, Rong Xiang, Shengyong Yang, Wei Yang, Guifeng Lin, Kai Chen, Guo Zhang, Qi-Zheng Sun, Lin-Li Li, Luyi Huang, Xi-Ting Jin
Publikováno v:
Journal of medicinal chemistry. 60(14)
Autophagy inducers represent new promising agents for the treatment of a wide range of medical illnesses. However, safe autophagy inducers for clinical applications are lacking. Inhibition of cdc2-like kinase 1 (CLK1) was recently found to efficientl
Autor:
Yanlin Wang, Guo Zhang, Rong Xiang, Xiang Wang, Qi-Zheng Sun, Shengyong Yang, Shenzhen Huang, Lin-Li Li, Luyi Huang, Chun-Li Song, Yiguo Hu, Xiaojuan Jiang
Publikováno v:
Journal of chemical information and modeling. 57(4)
SIRT2, which is a NAD+ (nicotinamide adenine dinucleotide) dependent deacetylase, has been demonstrated to play an important role in the occurrence and development of a variety of diseases such as cancer, ischemia-reperfusion, and neurodegenerative d
Autor:
Qi-Zheng Sun, Lin-Li Li, Jing-Jing Liu, Ren-Lin Zheng, Ze-Rong Wang, Yong Xu, Wen-Jing Wang, Chun-Hui Zhang, Shengyong Yang
Publikováno v:
Molecular Diversity. 18:403-409
Here, we describe the structural optimization of a known EGFR inhibitor (compound 1) that showed weak off-target activity against RET. Twenty-six analogs of 1 were synthesized. SAR analysis led to the discovery of several compounds that showed consid
Autor:
Heng-Xiu Yan, Jun Zou, Ze-Rong Wang, Shan Feng, Yang Lingling, Pan Ji, Guo-Bo Li, Qi-Zheng Sun, Shuang Ma, Shengyong Yang
Publikováno v:
European Journal of Medicinal Chemistry. 56:30-38
Aberrant activation of casein kinase 1 (CK1) has been demonstrated to be implicated in the pathogenesis of cancer and various central nervous system disorders. Discovery of CK1 inhibitors has thus attracted much attention in recent years. In this acc
Autor:
Shengyong Yang, Shu Zhou, Chan Zou, Xin Chen, Lin-Li Li, Guo-Bo Li, Shan Feng, Li-Jiao Wang, Chuan Cheng, Qi-Zheng Sun, Shuang Ma, Yang Lingling
Publikováno v:
Journal of medicinal chemistry. 56(4)
We describe the structural optimization of a hit compound, 1-(4-(1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenyl)-3-(3-methoxyphenyl)urea (1), which exhibits inhibitory activity but low potency against FLT3 and VEGFR2. A series of pyrazolo[3,4-d]pyrimid
Autor:
Jing-Jing Liu, Li-Jiao Wang, Shengyong Yang, Chun-Hui Zhang, Yong Xu, Yang Lingling, Jiao Yang, Pan Ji, Shan Feng, Zhi-Xing Cao, Ze-Rong Wang, Lei Zhong, Xiaoyan Wang, Yuquan Wei, Ren-Lin Zheng, Heng-Xiu Yan, Shuang Ma, Wei-Wei Li, Qi-Zheng Sun
Publikováno v:
Journal of medicinal chemistry. 55(8)
Structure-activity relationship (SAR) studies of 2-(quinazolin-4-ylthio)thiazole derivatives, which are for optimizing the in vitro and in vivo antiacute myeloid leukemia (AML) activity of a previously identified FLT3 inhibitor 2-(6,7-dimethoxyquinaz
Autor:
Qi-Zheng Sun, Gui-Feng Lin, Lin-Li Li, Xi-Ting Jin, Lu-Yi Huang, Guo Zhang, Wei Yang, Kai Chen, Rong Xiang, Chong Chen, Yu-Quan Wei, Guang-Wen Lu, Sheng-Yong Yang
Publikováno v:
Journal of Medicinal Chemistry; 7/27/2017, Vol. 60 Issue 14, p6337-6352, 16p